A5101991339- Fermentation and Sensory Analysis
- Probiotics and Fermented Foods
- Food Quality and Safety Studies
- Gut microbiota and health
- DNA Repair Mechanisms
- Microbial Metabolism and Applications
- Oral microbiology and periodontitis research
- Biochemical and biochemical processes
- Microbial Metabolic Engineering and Bioproduction
- Meat and Animal Product Quality
- Metabolomics and Mass Spectrometry Studies
- CRISPR and Genetic Engineering
- Tea Polyphenols and Effects
- Fungal and yeast genetics research
- Cancer-related Molecular Pathways
- Ubiquitin and proteasome pathways
- Horticultural and Viticultural Research
- Phytochemicals and Antioxidant Activities
- Infective Endocarditis Diagnosis and Management
- Genomics and Phylogenetic Studies
- Microbial Community Ecology and Physiology
- Cancer Genomics and Diagnostics
- Polyamine Metabolism and Applications
- Hippo pathway signaling and YAP/TAZ
- Microbial Metabolites in Food Biotechnology
Sixth Affiliated Hospital of Sun Yat-sen University
2024-2025
Sun Yat-sen University
2024-2025
China Agricultural University
2025
South China Agricultural University
2025
Sichuan University
2015-2024
State Key Laboratory of Oral Diseases
2021-2024
Zhejiang University
2005-2024
Peking University First Hospital
2024
Peking University
2003-2024
West China Hospital of Sichuan University
2021-2024
In both Drosophila and mammalian systems, the Hippo pathway plays an important role in controlling organ size, mainly through its ability to regulate cell proliferation apoptosis. The key component is Yes-associated protein YAP1, which localizes nucleus, functions as a transcriptional coactivator, regulates expression of several proliferation- apoptosis-related genes. negatively YAP1 activity by modulating nuclear-cytoplasmic localization phosphorylation-dependent manner. Here, we describe...
Through an shRNA-mediated loss-of-function screen, we identified PTPN14 as a potential tumor suppressor. interacts with yes-associated protein 1 (YAP1), member of the hippo signaling pathway. We showed that promotes nucleus-to-cytoplasm translocation YAP1 during contact inhibition and thus inhibits transactivation activity. Interestingly, stability was positively controlled by cell density. CRL2 LRR1 (cullin2 RING ubiquitin ligase complex/leucine-rich repeat 1) complex E3 targets for...
Daqu, an important fermentation starter for the production of Chinese liquor, as used in current study included traditional Daqu and fortified inoculated with Bacillus velezensis subtilis. To evaluate effect on strong-flavor liquor production, differences microbial communities among three inoculation patterns fermented grains (FG) were analyzed by Illumina MiSeq platform. A higher relative abundance dominant genera including Bacillus, Lactococcus, Aspergillus, Candida, lower Lactobacillus,...
Resistance to chemotherapy has been a major hurdle that limits therapeutic benefits for many types of cancer. Here we systematically identify genetic drivers underlying chemoresistance by performing 30 genome-scale CRISPR knockout screens seven chemotherapeutic agents in multiple cancer cells. Chemoresistance genes vary between conditions primarily due distinct background and mechanism action drugs, manifesting heterogeneous multiplexed routes towards chemoresistance. By focusing on...
Xiaoqu is a fermentation starter used in the production of jiu, which also traditional Chinese liquor. The quality and microbial community characteristics closely related with yield flavor feature fresh jiu. present study aims to explore mystery behind diversity volatiles through polyphasic detection methods such as Illumina MiSeq platform metabolite analyzing method. Results showed that differences among samples were significant. hydrolytic ability was positively correlated α- β-diversity...
Abstract Present study was to characterize the physiochemical properties, free amino acids (FAAs), volatiles and microbial communities of various moromi, respectively sampled from different stages high‐salt dilute‐state (HSDS) low‐salt solid‐state (LSSS) fermentation, using multiphase analyzing methods. Phospholipid fatty (PLFA) analysis indicated that Gram‐positive bacteria were dominant fungi principal microbes. For DGGE analysis, microbes in moromi mainly fell into Weissella ,...
Abstract The aim of this study was to investigate the dynamic volatile compounds in Zaopei during fermentation and distillation process by headspace solid‐phase microextraction‐gas chromatography mass spectrometry (HS‐SPME‐GCMS). Physicochemical properties analysis (fermented grains [FG], fermented mixed with sorghum [FGS], streamed [SG], Daqu [SGD]) showed distinct changes. A total number 66 were identified, which butanoic acid, hexanoic ethyl hexanoate, lactate, octanoate, hexyl...
Lysine acetylation is a frequently occurring post-translational modification (PTM), emerging as an important metabolic regulatory mechanism in prokaryotes. This process achieved enzymatically by the protein acetyltransferase (KAT) to specifically transfer acetyl group, or non-enzymatically direct intermediates (acetyl phosphate acetyl-CoA). Although lysine of glucosyltransferases (Gtfs), virulence factor Streptococcus mutans , was reported our previous study, KAT has not been identified....
Abstract Recruitment of RAD51 and/or DMC1 recombinases to single-strand DNA is indispensable for homology search and strand invasion in homologous recombination (HR) protection nascent strands at stalled replication forks. Thereafter RAD51/DMC1 dissociate, actively or passively, from these joint molecules upon repair releasing stress. However, the mechanism that regulates dissociation its physiological importance remain elusive. Here, we show a FLIP-FIGNL1 complex promote meiotic fork...