A5101858048- RNA and protein synthesis mechanisms
- Cancer-related molecular mechanisms research
- Computational Drug Discovery Methods
- Advanced Battery Materials and Technologies
- Cancer-related gene regulation
- Advanced Battery Technologies Research
- Circular RNAs in diseases
- RNA modifications and cancer
- MicroRNA in disease regulation
- Genomics and Chromatin Dynamics
- DNA and Nucleic Acid Chemistry
- Plant-based Medicinal Research
- Andrographolide Research and Applications
- DNA Repair Mechanisms
- CRISPR and Genetic Engineering
- Aerosol Filtration and Electrostatic Precipitation
- Traditional Chinese Medicine Analysis
- ATP Synthase and ATPases Research
- Cancer and Skin Lesions
- Science, Research, and Medicine
- Cell death mechanisms and regulation
- Biomarkers in Disease Mechanisms
- Machine Learning in Bioinformatics
- Yersinia bacterium, plague, ectoparasites research
- Reproductive Biology and Fertility
Peking University Third Hospital
2024-2025
Peking University
2022-2025
North China University of Water Resources and Electric Power
2024
Northwest Minzu University
2024
Ningxia Medical University
2023-2024
Hebei University of Technology
2024
Wenzhou Medical University
2023
Peking University Cancer Hospital
2022-2023
First Affiliated Hospital of Wenzhou Medical University
2023
Zhengzhou University
2022
Resistance to chemotherapy has been a major hurdle that limits therapeutic benefits for many types of cancer. Here we systematically identify genetic drivers underlying chemoresistance by performing 30 genome-scale CRISPR knockout screens seven chemotherapeutic agents in multiple cancer cells. Chemoresistance genes vary between conditions primarily due distinct background and mechanism action drugs, manifesting heterogeneous multiplexed routes towards chemoresistance. By focusing on...
Hepatocellular carcinoma (HCC) is a prevalent liver malignancy with complex etiology and generally poor prognosis. Recently, long non-coding RNAs (lncRNAs), non-protein-coding RNA molecules exceeding 200 nucleotides, have emerged as pivotal players in HCC, influencing its initiation, progression, invasion, metastasis. These lncRNAs modulate gene expression at epigenetic, transcriptional, post-transcriptional levels, actively participating the pathological physiological processes of HCC....
Radiotherapy is one of the most important treatment methods tumors. However, application radiotherapy in hepatocellular carcinoma (HCC) limited due to low tolerance normal liver cells for radiation and inherent resistance HCC. With in-depth study microRNAs (miRNAs) tumor therapy, regulation radiosensitivity by miRNAs has been a research hotspot recent years. In present study, expression miR-621 was lower HCC tissues cells, such associated with poor prognosis patients. addition, vivo vitro...
<p>With the prosperity of electric vehicles (EVs), thermal management lithium-ion battery (LIB) is crucial for ensuring safety drivers on EVs. Composite phase change material (CPCM) with high latent heat has a great promising prospect in systems (BTMS). However, efficiency CPCM limited due to leakage, low conductivity and flammability. Herein, novel multifunctional paraffin (PA), epoxy resin (ER), expanded graphite (EG), methyl MQ silicone (MQ) melamine phosphate (MP) (PEE/MQ/MP3) been...
MicroRNAs (miRNAs) are small RNAs that regulate target gene expression. Using microarray-based miRNA expression profiling, we compared the in granulocytes from four patients with acute myeloid leukemia and healthy controls. Thirty-four miRNAs were found to be differentially expressed, including 20 up-regulated 14 down-regulated. The of selected (miR-26a-5p miR-23b-3p) was independently validated 12 Notably, demonstrated peroxiredoxin III (PrxIII) is a common direct both miR-26a-5p...
Pursuing compounds capable of stimulating hair follicle growth or regeneration presents a significant challenge in dermatological research. Dermal papilla (DP) cells, which serve as dynamic niche for stem are often used to identify growth-promoting agents screening model. Here, we integrated human scalp single-cell RNA sequencing data with DP cells (hDPCs) gene expression profiles develop panel assessing inductive potential, then applied high-throughput sequencing-based (HTS2) method...
To investigate the expression of αA-crystallin (CRYAA) in age-related cataract (ARC) models and its role lens epithelial cells (LECs).We used Flow cytometry to detect apoptosis cell cycle HLEB3 Real-time fluorescence quantitative polymerase chain reaction CRYAA mRNA rabbit lens. The lenses as well proteins related autophagy transfected were detected by western blotting. structure rabbits was investigated using hematoxylin-eosin staining. Protein thermostability assay performed thermal...
Computational prediction of three-dimensional (3D) genome organization provides an alternative approach to overcome the cost and technical limitations Hi-C experiments. However, current models are constrained by their narrow applicability studying impact genetic variation on folding in specific cell lines, significantly restricting biological utility. We present Hi-Compass, a generalizable deep learning model that accurately predicts chromatin across diverse contexts, from bulk single-cell...
Thyroid carcinoma (TC) is currently the prevalent type of endocrine malignancy worldwide, having an incidence around 15.5 per 100,000 people. However, underlying mechanisms TC tumorigenesis remain to be further elucidated.Performing database analyses, Platelet-activating factor acetylhydrolase 1B3 (PAFAH1B3) was found dysregulated in several carcinomas and might trigger tumor occurrence as well progression TC. Clinicopathological information patients from our local validated cohort The...
Intrinsic DNA properties including bending play a crucial role in diverse biological systems. A recent advance high-throughput technology called loop-seq makes it possible to determine the bendability of hundred thousand 50-bp duplexes one experiment. However, it's still challenging assess base-resolution sequence large genomes such as human, which requires thousands experiments. Here, we introduce 'BendNet'-a deep neural network predict intrinsic at by using results yeast training data....
In response to the typical decay and fracture defects of composite insulators, a three-dimensional electrically thermally coupled simulation physical model was constructed based on finite element method, local electric field distortion temperature rise were analyzed. The study confirms that insulator interface’s axial thermal fields show U-shaped curve; interface strength is largest. There an gradient difference between mandrel sheath, concentrated at interface. edge defect largest, aberrant...
Embryonic stem (ES) cells are used in various fields for diverse purposes, including gene targeting, cell therapy, tissue repair, organ regeneration, and so on.However, studies on applications of ES hindered by ethical disputes regarding source.To circumvent issues, scientists have attempted to generate celllike cells, which not derived from the inner mass blastocyst-stage embryos.In 2006, Yamanaka first reprogrammed mouse embryonic fibroblasts into cell-like were called induced pluripotent...
Ubiquinone is an important cofactor that plays vital and diverse roles in many biological processes. Ubiquinone-binding proteins (UBPs) are receptor dock with ubiquinones. Analyzing identifying UBPs via a computational approach will provide insights into the pathways associated In this work, we were first to propose predictor (UBPs-Pred). The optimal feature subset selected from three categories of sequence-derived features was fed extreme gradient boosting (XGBoost) classifier, parameters...
AbstractNow all kinds of malicious acts appear in C2C online auctions, particularly the phenomenon trust lack and credit fraud is very outstanding. Therefore, how to build an effective model has become a burning problem. Based on analyzing limitations existing transaction mechanism, according characteristics (such as dynamic, innominate suppositional) problem, article proposes dynamic calculation reputation management mechanism trading based multi-Agent system. The consists three parts....
<title>Abstract</title> Purpose Network pharmacology and molecular docking were uesd to forecast the related effect targets potential signal pathways of Rhubarb Agastache rugosa in curing renal cancer. Methods Searching Traditional Chinese Medicine Systems Pharmacology Database Analysis Platform(TCMSP) screen effective ingredients rugosa, differential genes cancer obtained by searching GEO database. Construct regulatory networks protein-protein interaction(PPI) using Cytoscape 3.9.1...
Premature ovarian failure refers to function in women before the age of 40 years due follicular depletion or dysfunction resulting abnormal hormone levels. The etiology and pathogenesis premature may be related genetic, immunological, medical, environmental, infectious, psychological enzyme deficiencies. treatment involves Western medicine, Chinese a combination level includes level, cellular surgery aspect. This paper would like review progress etiology, recent years.
Abstract The recent outbreak of Corona Virus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been a threat to the global public health and economy, however, effective drugs treat COVID-19 are still lacking. Here, we employ deep learning-based drug repositioning strategy systematically screen potential anti-SARS-CoV-2 candidates that target cell entry mechanism SARS-CoV-2 virus from 2,635 FDA-approved 1,062 active ingredients Traditional...