A5101344616- Electrochemical Analysis and Applications
- Electrochemical sensors and biosensors
- CRISPR and Genetic Engineering
- DNA Repair Mechanisms
- Analytical Chemistry and Sensors
- Cancer Genomics and Diagnostics
- Magnetism in coordination complexes
- Catalytic Processes in Materials Science
- Catalysis and Hydrodesulfurization Studies
- Catalysis and Oxidation Reactions
- Cancer, Lipids, and Metabolism
- Cholesterol and Lipid Metabolism
- Epigenetics and DNA Methylation
- Antimicrobial agents and applications
- Natural Language Processing Techniques
- Fault Detection and Control Systems
- Ionic liquids properties and applications
- Lipid metabolism and disorders
- Topic Modeling
- Wound Healing and Treatments
- Advanced Text Analysis Techniques
- X-ray Diffraction in Crystallography
- Drug Transport and Resistance Mechanisms
- Conducting polymers and applications
- Metal-Organic Frameworks: Synthesis and Applications
Northeastern University
2024-2025
Harbin Institute of Technology
2023-2025
Foshan University
2025
Universidad del Noreste
2024
Zhejiang University
2023
North China University of Technology
2022
Nanchang Institute of Science & Technology
2022
Hebei Normal University
2021
Wuhan University
2007-2008
Tianjin University
2007
Resistance to chemotherapy has been a major hurdle that limits therapeutic benefits for many types of cancer. Here we systematically identify genetic drivers underlying chemoresistance by performing 30 genome-scale CRISPR knockout screens seven chemotherapeutic agents in multiple cancer cells. Chemoresistance genes vary between conditions primarily due distinct background and mechanism action drugs, manifesting heterogeneous multiplexed routes towards chemoresistance. By focusing on...
Abstract An ionic liquid (i.e., 1‐butyl‐3‐methylimidazolium hexafluorophosphate, BMIMPF 6 )‐single‐walled carbon nanotube (SWNT) gel modified glassy electrode (BMIMPF ‐SWNT/GCE) is fabricated. At it the voltammetric behavior and determination of p ‐nitroaniline (PNA) explored. PNA can exhibit a sensitive cathodic peak at −0.70 V (vs. SCE) in pH 7.0 phosphate buffer solution on electrode, resulting from irreversible reduction PNA. Under optimized conditions, current linear to concentration...
Dyslipidemia or hypercholesterolemia are among the main risk factors for cardiovascular diseases. Unraveling molecular basis of lipid cholesterol homeostasis would help to identify novel drug targets and develop effective therapeutics. Here, we adopt a systematic approach catalog genes underlying by combinatorial use high-throughput CRISPR screening, RNA sequencing, human genetic variant association analysis, proteomic metabolomic profiling. Such integrative multi-omics efforts...
ABSTRACT The rapid development of renewable energy has promoted the research integrated system. In particular, joint optimal scheduling and traditional thermal power units is key technology to solve current integration source network load balance. At present, total installed capacity cogeneration huge, which hinders flexibility grid regulation. Therefore, this paper proposes a robust strategy for plant‐level system considering electricity‐heat wind solar are connected in parallel with...
Abstract Severe working environments cause gas turbines to break down, which can directly affect their performance. Research on the diagnostic methods for turbine faults, such as, path faults and sensor failures, has always raised concerns. However, traditional fault diagnosis algorithms mostly use instantaneous data rather than time-series data, because they cannot efficiently analysis extract features improve algorithm accuracy. Problems with sparse samples categories are also encountered...
In recent years, scholars have paid increasing attention to the joint entity and relation extraction. However, most difficult aspect of extraction is extracting overlapping triples. To address this problem, we propose a model based on Soft Pruning GlobalPointer, short for SGNet. first place, BERT pretraining used obtain text word vector representation with contextual information, then local non-local information obtained through graph operations. Specifically, lack caused by rule-based...
Abstract Resistance to chemotherapy has been a major hurdle that limits therapeutic benefits for many types of cancer. Here we systematically identify genetic drivers underlying chemoresistance by performing 30 genome-scale CRISPR knockout screens seven chemotherapeutic agents in multiple cancer cells. Chemoresistance genes vary between conditions primarily due distinct background and mechanism action drugs, manifesting heterogeneous multiplexed routes towards chemoresistance. By focusing on...
Multidentate carboxylate ligands have been widely used in the construction of metal–organic frameworks (MOFs) owing to rich variety their coordination modes, which can lead crystalline products with interesting structures and properties. Two new main-group MOFs, namely, poly[[di-μ-aqua-diaqua(dimethylformamide)[μ 7 -5,5′-methylenebis(2,4,6-trimethylbenzene-1,3-dicarboxylato)]dibarium(II)] trihydrate], {[Ba 2 (C 23 H 20 O 8 )(C 3 NO)(H O) 4 ]·3H O} n or (BTMIPA)(DMF)(H ( 1 ), poly[[diaqua[μ 6...