Zhonghua Ning

ORCID: 0000-0003-0378-3859
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About
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Research Areas
  • Animal Nutrition and Physiology
  • Esophageal Cancer Research and Treatment
  • Gastric Cancer Management and Outcomes
  • Advanced Radiotherapy Techniques
  • MicroRNA in disease regulation
  • Lung Cancer Diagnosis and Treatment
  • Inflammatory Biomarkers in Disease Prognosis
  • Cancer-related molecular mechanisms research
  • Circular RNAs in diseases
  • Radiation Therapy and Dosimetry
  • Immune Cell Function and Interaction
  • Cancer Immunotherapy and Biomarkers
  • Lung Cancer Treatments and Mutations
  • Cancer Cells and Metastasis
  • Esophageal and GI Pathology
  • Livestock and Poultry Management
  • Peptidase Inhibition and Analysis
  • Gut microbiota and health
  • Genetic and phenotypic traits in livestock
  • Pancreatic and Hepatic Oncology Research
  • Moringa oleifera research and applications
  • Cell Adhesion Molecules Research
  • RNA modifications and cancer
  • Head and Neck Cancer Studies
  • Medical Imaging Techniques and Applications

China Agricultural University
2010-2025

Ministry of Agriculture and Rural Affairs
2021-2024

Beijing Normal University
2023

State Key Joint Laboratory of Environment Simulation and Pollution Control
2023

Soochow University
2004-2020

The First People's Hospital of Changzhou
2014-2016

This study was aimed to detect the correlation among EGFR/KRAS status and PD-1/PD-L1 expression in non-small-cell lung cancer (NSCLC) patients. PD-1 PD-L1 expressions were detected by immunohistochemistry 100 surgically resected adenocarcinoma tissues statistically correlated with clinicopathological characteristics including EGFR KRAS statuses. Besides, overall survival (OS) times analyzed. There a statistical significances between tumor (P = 0.043), higher mutation rate lower significance...

10.1080/15384047.2016.1156256 article EN Cancer Biology & Therapy 2016-03-08

Puan Panjiang black-bone chickens are renowned for their distinctive traits, deep black coloration, and high-quality protein content, making them a focus of genetic research due to unique egg-laying abilities. In this study, 110 were used investigate the effects natural artificial selection influencing egg production. Whole-genome resequencing data from red junglefowl (RJF) high-egg-production (HEP) low-egg-production (LEP) groups revealed significant variants associated with production...

10.3390/ani15030363 article EN cc-by Animals 2025-01-27

Radiotherapy is one of the most important treatment methods tumors. However, application radiotherapy in hepatocellular carcinoma (HCC) limited due to low tolerance normal liver cells for radiation and inherent resistance HCC. With in-depth study microRNAs (miRNAs) tumor therapy, regulation radiosensitivity by miRNAs has been a research hotspot recent years. In present study, expression miR-621 was lower HCC tissues cells, such associated with poor prognosis patients. addition, vivo vitro...

10.1016/j.ymthe.2018.11.005 article EN cc-by Molecular Therapy 2018-11-13

In the late growth stage of commercial Pekin ducks, a significant increase in feed intake and decline body weight gain have been observed, leading to impaired conversion efficiency. To address this issue, we investigated alterations production performance, blood biochemical indices, ileum tissue architecture, microbial community structure ducks. The primary objective was provide robust data supporting improvement meat duck efficiency during (28-42-days-old). Forty 28-day-old ducks were...

10.1016/j.psj.2024.103894 article EN cc-by-nc-nd Poultry Science 2024-05-30

Systemic immune-inflammation index (SII), based on peripheral lymphocyte, neutrophil, and platelet counts, was recently investigated as a prognostic marker in several tumors. However, SII has not been reported nasopharyngeal carcinoma (NPC). We evaluated the value of 327 patients with NPC. Univariate multivariate analyses were calculated by Cox proportional hazards regression model. The time-dependent receiver operating characteristics (ROC) curve used to compare discrimination ability for...

10.18632/oncotarget.19796 article EN Oncotarget 2017-08-02

Abstract Growing evidence indicates that nomogram combined with the biomarkers of systemic inflammation response could provide more accurate prediction than conventional staging systems in tumors. This study aimed to establish an effective prognostic for resectable thoracic esophageal squamouscell carcinoma (ESCC) based on clinicopathological parameters and inflammation-based scores. We retrospectively investigated 916 ESCC patients who underwent radical esophagectomy. The predictive...

10.1038/srep18811 article EN cc-by Scientific Reports 2015-12-22

This study aimed to investigate the effects of dietary yeast culture (YC) supplementation on egg production, quality, reproductive performance, immune functions, antioxidant capacity, and intestinal microbial structure aged hens. A total 224 Hy-Line Brown layers (54 weeks old) were randomly assigned two treatments. The control group was fed a basal diet YC supplemented with at 2.0 g/kg their diet. Each had seven replicates 16 hens each. conducted over period 8 weeks. Results indicated that...

10.3389/fmicb.2021.633276 article EN cc-by Frontiers in Microbiology 2021-03-19

Background: B-cell-specific moloney leukemia virus insertion site 1 (Bmi-1) plays important roles in various cancers, but its regulation through microRNAs (miRNAs) and functions hepatocellular carcinoma (HCC) remains unclear. Methods: We evaluated the expression prognostic significance of Bmi-1 HCC by using tissue samples The Cancer Genome Atlas (TCGA) data sets. relationship between miRNAs was verified bioinformatics prediction immunofluorescence. Colony formation apoptosis assays were used...

10.1021/acs.molpharmaceut.8b00302 article EN Molecular Pharmaceutics 2018-06-15

Double-yolk (DY) eggs refer to the presence of two yolks in an egg, and they are often present fowl flocks. As abnormal eggs, DY occur frequently early stages egg-laying hens, as well hens with sexual maturity. In order understand inheritant pattern explore candidate genes associated we selected over 10,000 white Leghorn (WL) chickens from 4 generations recorded data during egg laying period, including total number rate first 2 months period 18-58 weeks age (EN2month, EN38, EN58, DY2month,...

10.1016/j.psj.2025.105069 article EN cc-by-nc-nd Poultry Science 2025-03-01

Abstract Background The performance of single arc VMAT (VMAT1) for nasopharyngeal carcinoma (NPC) on the Axesse linac has not been well described in previous studies. purpose this study is to assess feasibility VMAT1 NPC by comparing dosimetry, delivery efficiency, and accuracy with dual (VMAT2), dynamic MLC intensity-modulated radiotherapy (dIMRT), step-and-shoot (ssIMRT). Methods Twenty consecutive patients non-metastatic were selected be planned VMAT1, VMAT2, dIMRT ssIMRT using Monaco 3.2...

10.1186/1748-717x-8-237 article EN cc-by Radiation Oncology 2013-10-14

This study determined the levels of serum ferritin (SF) and carcinoembryonic antigen (CEA) in elderly patients with advanced primary lung cancer (PLC), aimed to investigate correlation between SF level clinical characteristics compare positive rates CEA PLC those normal subjects. The 69 cases 63 controls were by electrochemiluminescence method. each independent clinicopathological characteristic was calculated. subjects compared. results revealed that significantly lower than LC (145.04 ±...

10.1007/s13277-014-2317-y article EN Tumor Biology 2014-07-15

Two patients with multiple lung metastases (≥ 5) were treated using frameless stereotactic body radiation therapy (SBRT) on an Elekta Axesse linear accelerator equipped interdigitation‐capable multileaf collimator and four‐dimensional cone‐beam CT (4D CBCT). The technique the early clinical outcomes evaluated. Patient A five B seven underwent SBRT (48 Gy/8 fractions for A, 42 Gy/7 B). treatments administered a 6 MV photon beam. nominal dose rate was 660 MUs/min. Patients positioned...

10.1120/jacmp.v15i4.4737 article EN cc-by Journal of Applied Clinical Medical Physics 2014-07-01

Objectives To evaluate levels of CD44 standard variant (CD44s), exon 3 (CD44v3) and 6 (CD44v6) protein in breast cancer tissue, investigate their relationships with clinicopathological characteristics the disease. Methods Immunohistochemistry for CD44s, CD44v3 CD44v6 was retrospectively performed on formalin-fixed paraffin wax-embedded tissue samples. Results Tumour samples from 60 patients were included. There a significant relationship between CD44s positivity tumour diameter lymph node...

10.1177/0300060514559793 article EN Journal of International Medical Research 2015-01-08

Recently, poultry industry has been seeking antibiotic residue-free products and safe nutritious feed additives. Whether rosemary ultrafine powder (RUP) affects productive performance by regulating the intestinal microbiome of aged layers remains unclear. Here, we investigated effects dietary RUP supplementation on production performance, egg quality, antioxidant capacity, microbial structure, metabolome hens. The results indicate that had no significant effect but significantly enhanced...

10.1016/j.psj.2024.104133 article EN cc-by-nc-nd Poultry Science 2024-07-31

The present study aimed to explore the importance of P53 and Cox-2 protein expression in esophageal cancer assess their influence on prognosis. was assessed samples from 195 patients subjected radical surgery at Changzhou First People's Hospital (Changzhou, China) between May 2010 December 2011. Expression Cox‑2 proteins were detected 60.5% (118/195) 69.7% (136/195) samples, respectively, co‑expressed 43.1% (84/195) samples. A correlation identified overall survival (OS) (P=0.0351) as well...

10.3892/ol.2015.3624 article EN Oncology Letters 2015-08-19

OBJECTIVE: To compare the dosimetric and efficiency differences for left-sided breast cancer radiotherapy after breast-conserving surgery among three different planning techniques: double-arc volumetric-modulate arc therapy (VMAT), step-shoot intensi

10.3233/thc-160746 article EN Technology and Health Care 2017-10-23
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