Biomimetic approach offers numerous opportunities to design therapeutic platforms with enhanced antitumor performance and biocompatibility. Herein we report red blood cell membrane-camouflaged nanoparticles (RBC(M(TPC-PTX))) for synergistic chemo- photodynamic therapy (PDT). Specifically, the inner core is mainly constructed by reactive oxygen species (ROS)-responsive PTX dimer (PTX2-TK) photosensitizer 5,10,15,20-tetraphenylchlorin (TPC). In vitro experiments show that prepared...

The limitation for the biomedical application of porous organic polymers (POPs) is big size and poor dispersibility in aqueous media. Herein, a nanoscale metal–organic framework (MOF)@POP composite, named UNM, has been synthesized by epitaxial growth photoactive porphyrin-POPs (H2P-POP) on outer surface amine containing UiO-66 (UiO-AM). After POPs, crystallization, pore structure, distribution UNM are retained well. formed possesses small less than 200 nm could be internalized cancer cells....

Photothermal conversion in the second near-infrared (NIR-II) window allows deeper penetration and higher exposure to lasers, but examples of NIR-II photothermal agents are mainly formulated by inorganic compounds. In view underlying influence materials, a novel nanoagent based on narrow band gap D-A conjugated polymer (TBDOPV-DT) with 2,2-bithiophene as donor thiophene-fused benzodifurandione-based oligo( p-phenylenevinylene) acceptor has been developed. More importantly, TBDOPV-DT...

Porphyrin-containing carbon dots (CDs) possess ultrasmall size, excellent water solubility, and photostability. These CDs can effectively generate cytotoxic singlet oxygen upon irradiation, induce the cell apoptosis. Photodynamic ability of inhibits growth hepatoma. This work not only sheds light on developing functional dots, but also highlights importance special-structure precursor molecules in synthesizing CDs. As a service to our authors readers, this journal provides supporting...

The introduction of multiple components into one crystalline metal–organic framework (MOF) provides a feasible approach to fully understand the correlation component heterogeneity and whole performance. Herein, photoactive tetratopic chlorin (TCPC) ligands with different geometry connectivity have been successfully incorporated Hf-UiO-66 archetype structure without altering underlying topology by facile strategy. Unlike previous porphyrin-nanoscale-MOFs (porphyrin-NMOFs) homogeneous...

The development of a simple and straightforward strategy to synthesize multifunctional carbon dots for photodynamic therapy (PDT) has been an emerging focus.

The oxygen-dependent feature of most photosensitizers (PSs) and the aggravated hypoxia tumor microenvironment seriously impede photodynamic therapy (PDT) effectiveness. However, this undesirable impediment can be utilized to further trigger activation hypoxia-sensitive prodrugs. Moreover, a combined used by associating PDT with hypoxia-activated chemotherapy. Herein, multifunctional Hf–porphyrin nanoscale metal–organic framework (NMOF) platform [Hf/tetra(4-carboxyphenyl)porphine (TCPP)] has...

Abstract Nanoparticle assembled from organic molecules is a versatile platform to integrate various functionalities for theranostics. In this work, nanoparticles are constructed chlorin dimers that synthesized by reducing porphyrin molecules. Chlorin can assemble into nanoscale aggregates in the absence of surfactants or other auxiliary agent. The resulting dimer exhibit much higher absorbance than counterparts, enhanced photodynamic and photothermal activity upon irradiation. forming be...

Covalent organic frameworks (COFs) have shown great potential in catalysis and the biomedical fields, but monodisperse COFs with tunable sizes are hard to obtain. Herein, we successfully developed a series of based on electron donor-acceptor strategy mild conditions. The synthetic exhibit excellent colloidal stability uniform spherical morphology. can be flexibly adjusted by amount catalyst, absorption spectra also vary sizes. By changing electron-donating ability monomers, corresponding...

Metal-organic framework (MOF)-polymer mixed-matrix membranes (MMMs) have shown their superior performance in gas separation. However, biological application has not been well-explored yet. Herein, a series of zirconium-based MOF MMMs with high loading and homogeneous composition prepared through facile drawdown coating process. Poly(ε-caprolactone) (PCL) selected as binder for its good biocompatibility biodegradability. Zr-MOF nanoparticles, UiO-66, MOF-525, utilized "filler" because...

Metal–organic frameworks (MOFs) take on highly ordered self-assembled structures and have gained much attention due to their intriguing structural features enormous applications.

Abstract Cancer immunotherapy has witnessed significant advances in the past decade, however challenges associated with immune‐related adverse effects and immunosuppressive tumor microenvironment, have hindered their clinical application. Stimuli‐activatable nanomedicines hold great potential for improving efficiency of cancer minimizing side via tumor‐specific accumulation, controllable drug release profile, combinational therapy by integrating multiple therapeutic regimens. In this review,...

Polymer-modified metal-organic frameworks combine the advantages of both soft polymers and crystalline (MOFs). It is a big challenge to develop simple methods for surface modification MOFs. In this work, MOF@microporous organic polymer (MOP) hybrid nanoparticles (UNP) have been synthesized by epitaxial growth luminescent boron-dipyrromethene (BODIPYs)-imine MOPs on UiO-MOF seeds, which exhibit low cytotoxicity, smaller size distribution, well-retained pore integrity, available functional...

Nanomedicines assembled directly from drug molecules possess several advantages, including precise molecular structure and high content of drugs. Herein, porphyrin-paclitaxel conjugates (Py-s-s-PTX) were synthesized by using a disulfide bond as linker. The Py-s-s-PTX could self-assemble into nanoparticles (Py-s-s-PTX NPs) with size about 100 nm via disulfide-induced assembly. NPs are highly stable under biological conditions be destroyed in the presence reducing agents revealed dynamic light...

Smart responsive nanomaterials, which are sensitive to biological signals, promising therapeutic formulations. It has been well studied that redox potential is much different at both tissue and cellular level. In this work, three organic nanoparticles with variable sensitivity were fabricated, their was evaluated compared in detail. First, diselenide, disulfide, carbon–carbon bond containing porphyrin dimers TPP-SeSe/TPP-SS/TPP-CC synthesized. Then, the corresponding self-assembled...

Developing a biocompatible nanotheranostic platform integrating diagnostic and therapeutic functions is great prospect for cancer treatment. However, it still challenge to synthesize agents using an ultra-facile method. In the research reported here, ultrasmall polyethylenimine-protected silver bismuth sulfide (PEI-AgBiS2) nanodots were successfully synthesized environmentally friendly strategy (1 min only at room temperature), which could be described as "rookie method". PEI-AgBiS2 show...

The therapeutic properties of light are well known for photodynamic or photothermal therapy, which could cause irreversible photodamage to tumor tissues. Although therapy (PDT) has been proved in the clinic, efficacy is not satisfactory because complicated microenvironments. For example, hypoxia solid a negative effect on generation singlet oxygen. To address issues PDT, leveraging alkyl radical an available option due oxygen-independent feature. In this work, new kind organic nanoparticles...

A protein-assisted synthesis method has been proposed for preparing stable covalent organic frameworks (COFs) with both photothermal and photodynamic activity under the excitation of a laser at single wavelength.