A5058662283- Nanoplatforms for cancer theranostics
- Luminescence and Fluorescent Materials
- Photodynamic Therapy Research Studies
- Nanoparticle-Based Drug Delivery
- Advanced biosensing and bioanalysis techniques
- Advanced Nanomaterials in Catalysis
- Supramolecular Self-Assembly in Materials
- Cloud Computing and Resource Management
- Metal-Organic Frameworks: Synthesis and Applications
- Porphyrin and Phthalocyanine Chemistry
- Advanced MIMO Systems Optimization
- Dendrimers and Hyperbranched Polymers
- Advanced Data Storage Technologies
- Gold and Silver Nanoparticles Synthesis and Applications
- Polydiacetylene-based materials and applications
- Software-Defined Networks and 5G
- Radical Photochemical Reactions
- Advanced Photocatalysis Techniques
- Advanced Wireless Network Optimization
- Immunotherapy and Immune Responses
- Molecular Sensors and Ion Detection
- Parallel Computing and Optimization Techniques
- 3D Printing in Biomedical Research
- IoT and Edge/Fog Computing
- Supramolecular Chemistry and Complexes
Sun Yat-sen University
2022-2025
Soochow University
2023-2025
Soochow University
2025
Zhejiang University
2014-2024
State Key Laboratory of Polymer Physics and Chemistry
2014-2024
Chinese Academy of Sciences
2013-2024
Changchun Institute of Applied Chemistry
2014-2024
City University of Hong Kong
2022-2023
University of Massachusetts Chan Medical School
2019-2023
Hefei University
2020
Organic triplet–triplet annihilation upconversion (TTA-UC) materials have considerable promise in areas as broad biology, solar energy harvesting, and photocatalysis. However, the development of highly efficient near-infrared (NIR) light activatable TTA-UC systems remains extremely challenging. In this work, we report on a method systematically tailoring an annihilator to attain such outstanding systems. By chemical modifications commonly used perylene annihilator, constructed family...
The diselenide-containing fluorescent molecules (SeBDP) and antitumor drug paclitaxel (SePTX) were synthesized used for constructing SeBDP nanoparticles (SeBDP NPs) SePTX NPs in aqueous solution through nanoprecipitation method. Both exhibit high stability excellent reduction-sensitivity. More interestingly, could coassemble into uniform spherical (co-NPs) with dual functions of fluorescence imaging activity. These organic be internalized by different cells as revealed confocal laser...
Selective photoactivation of inert aryl halides is a fundamental challenge in organic synthesis. Specially, the long-wavelength red light more desirable than widely-applied blue as excitation source for photoredox catalysis, due to its superior penetration depth. However, light-driven remains challenge, mainly because low energy single photon. Herein, we report photoreduction bromides/chlorides with 656 nm LED via triplet-triplet annihilation (TTA) strategy. This method based on our...
One-step synthesis of fluorescent molecules (SNBDP) containing one disulfide bond and two <italic>o</italic>-nitrobenzyl groups was demonstrated <italic>via</italic> multi-component Passerini reaction.
Near-infrared fluorescent nanovesicles were prepared by self-assembly of block copolymer hydrophilic poly(ethylene glycol) boron-dipyrromethenes in aqueous solution. The fluorescence enhancement induced dissociation could be used as a smart imaging and diagnostic tool. This nanovesicle encapsulate the antitumor drug, provide powerful platform for imaging-guided tumor-specific drug delivery therapy.
Organic self-assembled co-crystals have garnered considerable attention due to their facile synthesis and intriguing properties, but supramolecular interactions restrict stability in aqueous solution, which is especially important for biological applications. Herein, we report on the first application of dispersible organic via construction metal-organic framework (MOF) -stabilized co-crystals. In particular, built an electron-deficient MOF with naphthalene diimide (NDI) as ligand...
The discovery and synthesis of theranostic nanomedicines with high loading imaging therapeutic agents is challenging. In this work, a polymer assembling strategy was used to make nanoparticles exceptionally agent. As an example, poly(heptamethine) synthesized via multicomponent Passerini reaction, then assembled into in the presence poly(ethylene glycol)2k-block-poly(d,l-lactide)2k (PEG–PLA) heptamethine (>50%). formed could be for bimodal bioimaging photothermal therapy. provided...
Smart responsive nanomaterials, which are sensitive to biological signals, promising therapeutic formulations. It has been well studied that redox potential is much different at both tissue and cellular level. In this work, three organic nanoparticles with variable sensitivity were fabricated, their was evaluated compared in detail. First, diselenide, disulfide, carbon–carbon bond containing porphyrin dimers TPP-SeSe/TPP-SS/TPP-CC synthesized. Then, the corresponding self-assembled...
It is a challenge to develop multifunctional theranostic agents in one molecule, which simultaneously possesses tumor imaging ability with high signal-to-noise ratio and excellent therapeutic activity. In this work, we synthesized screened series of BODIPY (BDP) various absorption fluorescence. The interplay the molecular structure, pH-sensitive emission, photodynamic photothermal activities was well studied detail. Photoinduced electron transfer, intramolecular charge heavy atom effect were...
Amphiphilic photosensitizers are made from boron dipyrromethene and poly(ethylene glycol) by using a thioketal linker, which is reactive oxygen species-responsive for photodynamic photothermal therapy.
Heretofore, conjugated polymers (CPs) attract considerable attention in photothermal therapy (PTT). Although various CPs with different structures have been reported, the suboptimal circulation persistence and biodistribution limit their efficacy tumor treatment. Human serum albumin (HSA), an endogenous plasma protein, has widely functioned as a carrier for therapeutic agents. Herein, we construct nanocomplex C16 pBDP@HSA nanoparticles (NPs) from hydrophobic 4,4-difluoro-4-bora-3 a,4...
Conjugated polymers (CPs) have drawn growing attention in cancer phototherapy and imaging due to their large extinction coefficients, robust photostability, good biocompatibility. Herein, we propose a new type of photothermal therapy materials on the basis BODIPY-diketopyrrolopyrrole CPs, where number methyl substituents at β β′ positions BODIPYs is variable, allowing us investigate interplay between structure monomers related properties CPs. Combining experimental data with theoretical...
Abstract Background The misfolding and deposition of amyloid beta (Aβ) in human brain is the main hallmark Alzheimer's disease (AD) pathology. One drivers Alzheimer´s pathogenesis production soluble oligomeric Aβ, which could potentially serve as a biomarker AD. Methods Given that diphenylalanine (FF) at C‐terminus Aβ fragments plays key role inducing AD pathology, based on hydrophobic structure FF, we synthesized near‐infrared BF2‐dipyrrolmethane fluorescent imaging probe (NB) to detect...
Phototheranostics integrating optical imaging and phototherapy has attracted extensive attention. Achieving nanophototherapeutics with near infrared (NIR)-light synchronously triggered photodynamic therapy (PDT) photothermal (PTT) is challenging. Herein, we develop a multifunctional theranostic nanoplatform prepared from the co-assembly of NIR boron dipyrromethene (BODIPY) cooperative D-π-A structure thiophene-BODIPY core benzene-diethylamino, choline phosphate lipid. The as-fabricated...
Light‐activatable prodrugs have been applied in precision cancer therapy because of their spatiotemporal controllability and minimal toxic side effects. However, the reported were limited by ultraviolet visible light regions, which seriously restricted application deep tissues. Developing a near‐infrared (NIR) light‐activatable release system remains great challenge. Herein, 808 nm constructed with imiquimod (R837) NIR boron dipyrromethene (BODIPY) via reactive oxygen species (ROS)‐cleavable...
Light-activatable prodrugs have been applied in precision cancer therapy because of their spatiotemporal controllability and minimal toxic side effects. However, the reported were limited by ultraviolet visible light regions, which seriously restricted application deep tissues. Developing a near-infrared (NIR) light-activatable release system remains great challenge. Herein, 808 nm constructed with imiquimod (R837) NIR boron dipyrromethene (BODIPY) via reactive oxygen species (ROS)-cleavable...