Biomimetic and flexible bamboo-like hybrid fibers are produced using a novel one-step strategy. By combining droplet microfluidic technique with wet-spinning process, biocompatible microfibers incorporated polymer spheres or multicellular spheroids. As result of the controllability this approach, it has potential applications in materials science tissue engineering. service to our authors readers, journal provides supporting information supplied by authors. Such peer reviewed may be...

Abstract Organic diradicaloids with unique open‐shell structures and properties have been widely used in organic electronics spintronics. However, their advantageous optical explored less the biomedical field. In this work, photothermal conversion behaviors of a boron‐containing diradicaloid (BOD) are reported. BOD can assemble 1,2‐distearoyl‐sn‐glycero‐3‐phosphoethanolamine‐poly(ethylene glycol) to form rodlike nanoparticles (BOD NPs). These as‐prepared NPs exhibit high capability robust...

A droplet-based microfluidic device integrated with a novel floatage-based trap array and tapered immobilization channel was presented for characterizing the neurotoxin-induced multiple responses in individual Caenorhabditis elegans (C. elegans) continuously. The established enabled evaluations of movement fluorescence imaging analysis C. simultaneously. utility this demonstrated by pharmacological evaluation neurotoxin (6-hydroxydopamine, 6-OHDA) triggered mobility defects, neuron...

A multifunctional droplet microdevice was presented for the post-embryonic development study of<italic>C. elegans</italic>initiating from L1 stage, and effect of HIF-1 on worm investigated.

C. elegans is widely used as a model organism in the study of aging and evaluation anti-aging drugs due to its unique characteristics. In this work, we set out investigate polydatin, natural resveratrol glycoside, role extending lifespan, improving oxidative stress resistance, possible regulation mechanism involved Insulin/IGF-1 signaling (IIS) pathway for first time by using flexible microfluidic device. The effects polydatin on mobility expression aging-related proteins genes were...

Photodynamic therapy (PDT) has aroused great interest in antimicrobial treatment because it can take advantage of the reactive oxygen species (ROS) generated by photosensitizers under laser irradiation to kill bacteria efficiently without causing drug resistance. Herein, we designed a 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY) photosensitizer (BDPI-TPP) with triphenylphosphine (TPP) cation for highly efficient PDT against bacteria. The prepared BDPI-TPP nanoparticles (BDPI-TPP NPs)...

A cationic BODIPY photosensitizer decorated with quaternary ammonium has been prepared that exhibits excellent photodynamic antibacterial effects.

Enhancing the interactions between photosensitizers and bacteria is key to developing effective photodynamic antibacterial agents. However, influence of different structures on therapeutic effects has not been systematically investigated. Herein, 4 BODIPYs with distinct functional groups, including phenylboronic acid (PBA) group pyridine (Py) cations, were designed explore their activities. The BODIPY PBA (IBDPPe-PBA) exhibits potent activity against planktonic Staphylococcus aureus (S....

Type I photodynamic therapy (PDT) exhibits outstanding therapeutic effects in hypoxic environments tumors, but the design of type photosensitizers (PSs), especially those with simple structures dramatic properties, remains a challenge. Herein, we report strategy for developing PSs one molecule afterglow luminescence. As proof concept, 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY) PS (BIP) bearing water-soluble poly(ethylene glycol) (mPEG550) chains is synthesized, and BIP can...

Diketopyrrolopyrrole (DPP) is now widely used in the phototherapy of tumors, but most reported DPP molecules have no absorption near-infrared (NIR) region. In this study, 3 derivatives with donor–acceptor–donor (D-A-D) structures were designed and synthesized, which named OODPP, OSDPP, SSDPP according to number thione groups. Their spectra are gradually red-shifted an increase However, after preparation nanoparticles (NPs), OSDPP NPs show maximum red shift peak at 786 nm excellent...

It remains a clinical challenge to treat triple-negative breast cancer due its aggressiveness and metastasis. Photothermal therapy (PTT) in combination with checkpoint blockade immunotherapy offers promising strategy for...

Industrial Control System (ICS) security has become increasingly important as attacks targeting ICSs are more prominent. Although many off-the-shelf industrial network intrusion detection mechanisms have been presented in the past, attackers always found unique disguisable ways to bypass detections and disrupt actual control processes. To mitigate this deficiency, we present a novel scheme for of process attacks, called <sc xmlns:mml="http://www.w3.org/1998/Math/MathML"...

Background Traditionally, scientists studied microbiology through the manner of batch cultures, to conclude dynamics or outputs by averaging all individuals. However, as researches go further, heterogeneities among individuals have been proven be crucial for population and fates. Results Due limit technology, single‐cell analysis methods were not widely used decipher inherent connections between individual cells populations. Since early decades this century, rapid development microfluidics,...

Abstract Coordinated regulation of alternative pre-mRNA splicing is essential for germ cell development. However, the molecular mechanism underlying that control mRNA expression during development remains poorly understood. Herein, we showed hnRNPH1, an RNA-binding protein, highly expressed in reproductive system and localized chromosomes meiotic cells but excluded from XY body pachytene spermatocytes recruits regulators PTBP2 SRSF3 cooperatively regulates critical genes are required...

Biomimetic and flexible bamboo-like hybrid fibers are fabricated by J. Qin co-workers as described on page 2494 using a novel one-step strategy combining droplet microfluidic technique with wet-spinning process. The polymer spheres multicellular spheroids can be incorporated into the biocompatible microfibers in controllable way, which has extensive applications materials science tissue engineering.