A5100755555- Gut microbiota and health
- Probiotics and Fermented Foods
- Retinoids in leukemia and cellular processes
- RNA modifications and cancer
- Microbial Metabolites in Food Biotechnology
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- interferon and immune responses
- RNA Research and Splicing
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Toxin Mechanisms and Immunotoxins
- Immunotherapy and Immune Responses
- Acute Myeloid Leukemia Research
- Health Systems, Economic Evaluations, Quality of Life
- Renal and related cancers
- DNA Repair Mechanisms
- Pharmacological Effects of Natural Compounds
- Cancer Research and Treatments
- Cancer therapeutics and mechanisms
- Antimicrobial Peptides and Activities
- Immune cells in cancer
- Cytomegalovirus and herpesvirus research
- Immune Response and Inflammation
Nanchang University
2023-2025
State Key Laboratory of Food Science and Technology
2023-2024
Huazhong University of Science and Technology
2021-2024
Baoding People's Hospital
2020-2024
Guangdong Medical College
2015-2023
Zhumadian Central Hospital
2022
Chengdu University of Traditional Chinese Medicine
2022
Education Department of Heilongjiang Province
2021
Shanghai Jiao Tong University
2021
Southern Medical University
2016-2021
Necroptosis, a form of regulated necrosis, participates in tumor development and dying cell immunogenicity. However, it remains unclear how cell–intrinsic necroptotic signaling contributes to radiation-induced antitumor immunity. Here, we found that the ZBP1-MLKL cascade irradiated cells was essential for ZBP1-dependent activation MLKL potentiated type I interferon responses following irradiation. Mechanistically, induced cytoplasmic DNA accumulation and, turn, autonomously activated...
Coordinated regulation of alternative pre-mRNA splicing is essential for germ cell development. However, the underlying molecular mechanism that controls mRNA expression during development remains elusive. Herein, we show hnRNPH1 highly expressed in reproductive system and recruits PTBP2 SRSF3 to modulate cells. Conditional knockout Hnrnph1 spermatogenic cells causes many abnormal events, thus affecting genes related meiosis communication between Sertoli This characterized by asynapsis...
Let-7a has been shown to play important roles in nasopharyngeal carcinoma (NPC) cell proliferation and apoptosis, but little is known about the function mechanism of let-7a metastasis. We aimed investigate metastasis clarified regulation high mobility group A2 (HMGA2) by let-7a. The expression levels HMGA2 were examined NPC clinical specimens using quantitative reverse transcription-PCR (RT-qPCR). was confirmed as a target through luciferase reporter assays, RT-qPCR, Western blotting....
Objective: Hypertension is one of the most common public health issues worldwide. However, few existing studies examining health-related quality life (HRQoL) were conducted on elderly patients with hypertension in China. Hence, this study aimed to assess HRQoL and its influencing factors using EuroQol five-dimensional-three-level (EQ-5D-3L) Methods: Data obtained from 6th National Health Service Survey Heilongjiang province June July 2018, a stratified multistage random cluster sampling...
The prognosis of acute promyelocytic leukemia (APL) in the elderly is poorer than that younger patients after treatment with all-trans retinoic acid plus chemotherapy, which current standard therapy for APL. A significantly higher mortality during consolidation was found, mainly due to deaths from sepsis following chemotherapy-induced myelosuppression.A total 33 aged 60 years or older de novo APL were treated single-agent arsenic trioxide (ATO) remission induction and postremission therapy....
There is increasing evidence demonstrating that disorders affecting microRNAs (miRs) influence tumorigenesis and progression, which results in a poor prognosis patients with breast cancer (BC). In the present study, precise molecular mechanism underlying role of miR-320 progression BC was investigated. Reverse transcription-quantitative PCR conducted to determine mRNA expression, western blot analysis used test protein levels. An MTT assay detect cell viability Transwell assays were analyze...
Non-digestible isomaltooligosaccharide drives Lactiplantibacillus plantarum ZDY2013 to colonize the gut and alleviate DSS-induced colitis.
Background The breast cancer is most frequently diagnosed in the women worldwide. Our study investigated anticancer effect of peiminine, an alkaloid obtained from Fritillaria thunbergii, against carcinoma. Materials and Methods toxicity LD50 subsequent doses peiminine for carcinogenic study. vitro chemotherapeutic assessment was performed on MCF7 cells through MTT assay flow cytometry. developed rats via induction DMBA (5 mg/kg, i.v.) sustained 24 weeks. were assessed histopathological...
Mobile health applications are increasingly acknowledged as effective instruments for enhancing self-management among individuals with diabetes. However, despite their potential, the extent of global usage this population remains unclear. To better understand this, we conducted a systematic review existing studies to explore worldwide mobile by and identify factors that influence usage. A total 33 studies, involving 15 181 subjects, were analyzed. The findings indicated that, across...
Mammalian testis exhibits remarkably high transcriptome complexity, and spermatogenesis undergoes two periods of transcriptional cessation. These make the RNA-binding proteins (RBPs) utmost importance during male germ cell development. Heterogeneous nuclear ribonucleoproteins (hnRNPs) are a large family RBPs implicated in many steps RNA processing; however, their roles largely unknown. Here, we investigated expression pattern 12 hnRNP members mouse testes found that most detected highly...
This study aimed to assess the health utility of leukemia patients in China using EQ-5D-5L, compare it with population norms, and identify potential factors associated utility.A hospital based cross-sectional survey was conducted three tertiary hospitals from July 2015 February 2016. A total 186 completed EQ-5D-5L their scores were calculated Chinese value set. dimensions compared China's norms Kruskal-Wallis test chi square test. Potential identified Tobit regression.The mean leukemia,...
Bladder cancer (BC) is the tenth most commonly diagnosed cancer. High recurrence, chemoresistance, and low response rate hinder effective treatment of BC. Hence, a novel therapeutic strategy in clinical management BC urgently needed. Medicarpin (MED), an isoflavone from Dalbergia odorifera, can promote bone mass gain kill tumor cells, but its anti-BC effect remains obscure. This study reve aled that MED effectively inhibited proliferation arrested cell cycle at G1 phase lines T24 EJ-1 vitro....
Glabridin (GLA) has a variety of biological activities and therapeutic effects in cancers. Whereas the effect GLA on urothelial bladder carcinoma (UBC) cells its underlying mechanisms remain unknown. The study revealed UBC potential mechanism inducing cell apoptosis vivo vitro. After treated with different concentrations GLA, activity decreased time- dose-dependent manner. IC50 values BIU-87 EJ at 48 h were 6.02 μg/ml (18.6 μm) 4.36 (13.4 μm), respectively. Additionally, GLA-induced cycle...