A5100348765- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Retinoids in leukemia and cellular processes
- Acute Myeloid Leukemia Research
- Antioxidant Activity and Oxidative Stress
- Reproductive Biology and Fertility
- Crystallography and molecular interactions
- Genetics and Physical Performance
- Spectroscopy Techniques in Biomedical and Chemical Research
- Microbial Metabolic Engineering and Bioproduction
- Neurobiology and Insect Physiology Research
- Nicotinic Acetylcholine Receptors Study
- Nutritional Studies and Diet
- Ion channel regulation and function
- Biochemical and biochemical processes
- Reproductive System and Pregnancy
- Pharmacological Effects of Natural Compounds
- Microtubule and mitosis dynamics
- Immune Cell Function and Interaction
- Kruppel-like factors research
- Veterinary Pharmacology and Anesthesia
- Cancer Mechanisms and Therapy
- Cancer, Stress, Anesthesia, and Immune Response
- RNA Interference and Gene Delivery
- Sodium Intake and Health
Ningxia Medical University
2021-2025
Nanjing Forestry University
2024
Guilin Medical University
2023-2024
Shandong Sport University
2023-2024
Chinese Academy of Agricultural Sciences
2022
Institute of Special Animal and Plant Sciences
2022
Harbin Medical University
2012-2021
First Affiliated Hospital of Harbin Medical University
2014-2021
Mudanjiang Medical University
2017-2021
Ningxia Center for Diseases Prevention and Control
2021
Environmental factors play an important role in the development of rheumatoid arthritis (RA). Among these factors, smoking is generally considered to be established risk factor for RA. Data regarding impact diet on RA limited. This study assessed dietary patterns susceptibility Chinese populations. was a large scale, case-control composed 968 patients with and 1037 matched healthy controls. Subjects were recruited from 18 teaching hospitals. Socio-demographic characteristics intakes 5 years...
The PML/RARα fusion protein is the oncogenic driver in acute promyelocytic leukemia (APL). Although most APL cases are cured by PML/RARα-targeting therapy, relapse and resistance can occur due to drug-resistant mutations. Here we report that thermal stress destabilizes protein, including clinically identified mutants. AML1/ETO TEL/AML1 oncofusions show similar heat shock susceptibility. Mechanistically, mild hyperthermia stimulates aggregation of complex with nuclear receptor corepressors...
The prognosis of acute promyelocytic leukemia (APL) in the elderly is poorer than that younger patients after treatment with all-trans retinoic acid plus chemotherapy, which current standard therapy for APL. A significantly higher mortality during consolidation was found, mainly due to deaths from sepsis following chemotherapy-induced myelosuppression.A total 33 aged 60 years or older de novo APL were treated single-agent arsenic trioxide (ATO) remission induction and postremission therapy....
Alongside fermentable sugars, weak acids, and furan derivatives, lignocellulosic hydrolysates contain non-negligible amounts of lignin-derived aromatic compounds. The biological funnel lignin offers a new strategy for the “natural” production protocatechuic acid (PCA). Herein, Pseudomonas putida KT2440 was engineered to produce PCA from monomers in by knocking out protocatechuate 3,4-dioxygenase overexpressing vanillate-O-demethylase endogenously, while acetic used cell growth. sugar...
Abstract As the global population ages, research on pathogenesis and treatment options for older patients with dementia has become increasingly important. Vascular (VaD), second most frequent type of dementia, is characterized by vascular impairment caused inadequate blood supply to brain. VaD a complex neurological disorder involving multiple cells signaling pathways, its prevention pose clinical challenges significant behavioral implications. Glutamate, abundant amino acid in brain, plays...
Previous studies have highlighted that the transforming growth factor‑β1 (TGF‑β1) pathway may be activated by hypoxic conditions. TGF‑β1 also participates in regulation of proliferation, differentiation, migration and apoptosis various cell types. Furthermore, has been reported to participate progression pulmonary arterial hypertension (PAH). However, effect on smooth muscle cells (PASMCs) corresponding molecular mechanisms remain unclear. The present study aimed determine whether protects...
Objective: Many patients with psoriasis have developed acute promyelocytic leukemia (APL) whereas few reports on psoriasis-associated APL were found in the published literature. This study was aimed to etiology, clinical characteristics, and prognosis of map a suitable treatment regime for this condition.Methods: retrospectively analyzed data 17 diagnosed treated our hospital past decade.Results: The accounted 8.3% total de novo during same period hospital. Their characteristics similar...
Objective . To study the effects and underlying mechanisms of voltage-gated K + channels on proliferation multiple myeloma cells. Methods RPMI-8226 MM cell line was used for experiments. Voltage-gated currents resting potential were recorded by whole-cell patch-clamp technique. RT-PCR detected Kv channel mRNA expression. Cell viability analyzed with MTT assay. counting system employed to monitor proliferation. DNA contents volume flow cytometry. Results Currents in cells confirmed be...
Abstract Two novel aminooligosaccharides were separated from the culture filtrate of Streptomyces coelicoflavus ZG0656. Their chemical structures determined by acidic hydrolysis, electrospray‐ionization tandem mass spectrometry (ESI‐MS/MS), and NMR spectroscopy. The compounds named acarviostatins III0(−1) III23 according to nomenclature this group metabolites. two both mixed noncompetitive inhibitors porcine pancreatic α ‐amylase (PPA). inhibition constants ( K i ) for 0.009 0.026 μ M ,...
The aim of this study was to investigate associations 3 common polymorphisms in the VEGF gene, -2578C>A, -634C>G, and 936C>T, with risk tetralogy Fallot (TOF) Chinese Han children.From January 2010 June 2013, a total 400 pediatric subjects were recruited, including 160 cases TOF (TOF group) 240 healthy controls (control group). genotypes polymorphisms, analyzed by polymerase chain reaction restriction fragment length polymorphism. All data SPSS 18.0 software.No significant differences...
Xenopus nuclear factor 7 (xnf7) is a phosphoprotein that encoded by member of novel zinc finger gene family and likely functions as transcription factor. It possesses localization signal (NLS) similar to the bipartite basic NLS nucleoplasmin, but unlike which re-enters nuclei immediately after fertilization, xnf7 remains cytoplasmic until mid-blastula transition (MBT). We have measured accumulation injected labeled protein or produced from synthetic transcripts in oocyte (GV). The data show...
Arsenic trioxide (ATO) exhibits substantial clinical efficacy in the treatment of acute promyelocytic leukemia (APL). Here, we investigated whether ATO exerts its by affecting regulatory T (Treg) cells. We determined influenced amount and function purified Treg also examined effect on cells from APL patients. induced apoptosis dampened inhibition effector (Teff) proliferation secretion cytokine cell levels peripheral blood serum IL-10 were dramatically decreased patients after single...
Objective: To explore the preventive effect of aspirin on cardiovascular complications in prostate cancer after endocrinotherapy. Materials and Methods: A total 92 patients with were divided into observation group (n=44) control (n=48). The was treated medical castration plus anti-androgenic drugs. Based above treatment, added aspirin. follow-up duration 2 years. changes partial prothrombin time (PT), activated thromboplastin (APTT), platelet aggregation rate (PAG), prostate-specific antigen...
The pathogenesis of therapy-induced differentiation syndrome (DS) in patients with acute promyelocytic leukemia (APL) remains unclear. In this study, mRNA and microRNA (miRNA) expression profiling peripheral blood APL cells from complicated vs. without DS were integratively analyzed to explore the mechanisms underlying arsenic trioxide treatment-associated DS. By integrating differentially expressed data microRNAs their computationally predicted target genes, as well transcription factors...
ADD1 (adducin-1) and TPX2 (targeting protein for Xklp2) are centrosomal proteins regulate mitotic spindle assembly. Mammalian oocytes that segregate homologous chromosomes in Meiosis I sister chromatids II with a lacking centrosomes more prone to chromosome segregation errors than mitosis. However, the regulatory mechanisms of oocyte assembly functions this process remain elusive.We found expression levels localization ADD1, S726 phosphorylated (p-ADD1), exhibited assembly-dependent dynamic...