A5100652411- Retinal Development and Disorders
- Neuroscience and Neuropharmacology Research
- Photoreceptor and optogenetics research
- Reproductive Biology and Fertility
- Glaucoma and retinal disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Receptor Mechanisms and Signaling
- Prenatal Screening and Diagnostics
- Nicotinic Acetylcholine Receptors Study
- Intracerebral and Subarachnoid Hemorrhage Research
- Plant Diversity and Evolution
- Assisted Reproductive Technology and Twin Pregnancy
- Spectroscopy Techniques in Biomedical and Chemical Research
- Sperm and Testicular Function
- Spectroscopy and Chemometric Analyses
- Neurological Disease Mechanisms and Treatments
- Retinal Diseases and Treatments
- Kruppel-like factors research
- Visual perception and processing mechanisms
- Fern and Epiphyte Biology
- Plant and Fungal Species Descriptions
- Advanced Fluorescence Microscopy Techniques
- Cerebrovascular and Carotid Artery Diseases
- Neuroscience and Neural Engineering
- Nerve injury and regeneration
University of Utah
2013-2025
Changchun University of Chinese Medicine
2024-2025
Veterans Health Administration
2021-2025
Guilin Medical University
2019-2024
Shandong Provincial Hospital
2024
Shandong University
2024
Shanghai Jiao Tong University
2024
Tsinghua University
2009-2024
Education Department of Jiangxi Province
2024
Shanghai First People's Hospital
2024
Synucleins are a vertebrate-specific family of abundant neuronal proteins. They comprise three closely related members, α-, β-, and γ-synuclein. α-Synuclein has been the focus intense attention since mutations in it were identified as cause for familial Parkinson's disease. Despite their disease relevance, normal physiological function synucleins remained elusive. To address this, we generated characterized αβγ-synuclein knockout mice, which lack all members this protein family. Deletion...
Vesicular transporters regulate the amount and type of neurotransmitter sequestered into synaptic vesicles and, hence, kind signal transmitted to postsynaptic neurons. Glutamate is prominent excitatory in retina; GABA glycine are main inhibitory neurotransmitters. Little known about ontogeny vesicular neurotransmission retina. We investigated expression glutamatergic [vesicular glutamate transporter 1 (VGLUT1)] GABA/glycinergic GABA/glycine (VGAT)] postnatal VGLUT1 labels synapses. vesicle 2...
We have studied GABAergic synaptic transmission in retinal ganglion cells and hippocampal pyramidal to determine, at a cellular level, what is the effect of targeted disruption gene encoding synthetic enzyme GAD65 on release γ-aminobutyric acid (GABA). Neither size nor frequency GABA-mediated spontaneous inhibitory postsynaptic currents (IPSCs) were reduced retina or hippocampus GAD65−/− mice. However, GABA during sustained activation was substantially reduced. In both electrical- K +...
Immunologic changes in the hematoma of patients with intracerebral hemorrhage (ICH) and contribution these to prognosis are unknown. We collected blood samples fluid from 35 acute ICH (<30 hours symptom onset) 55 age-matched healthy controls. Using flow cytometry ELISA, we found that percentages granulocytes, regulatory T cells, helper (Th) 17 dendritic cells were higher peripheral than controls, whereas lymphocytes, M1-like macrophages, M2-like macrophages lower. Levels IL-6, IL-17, IL-23,...
Retinal ganglion cells (RGCs) are the only output neurons that conduct visual signals from eyes to brain. RGC degeneration occurs in many retinal diseases leading blindness and increasing evidence suggests RGCs susceptible various injuries a type-specific manner. Glutamate excitotoxicity is pathological process by which damaged killed excessive stimulation of glutamate receptors it plays central role death CNS diseases. The purpose this study characterize susceptibility genetically...
Recent studies have indicated that suppressing oxidative stress and ferroptosis can considerably improve the prognosis of intracerebral hemorrhage (ICH). Withaferin A (WFA), a natural compound, exhibits positive effect on number neurological diseases. However, effects WFA ferroptosis-mediated signaling pathways to ICH remain unknown. In this study, we investigated neuroprotective underlying mechanism for in regulation ICH-induced ferroptosis. We established mouse model by injection...
In clinical work, accurately measuring the volume and size of breast cancer is significant to develop a treatment plan. However, it time-consuming, inter- intra-observer variations among radiologists exist. The purpose this study was assess performance Res-UNet convolutional neural network based on automatic segmentation for volumetric measurement mass enhancement magnetic resonance imaging (MRI).A total 1,000 female patients who underwent preoperative 1.5-T dynamic contrast-enhanced MRI...
Through transcriptional regulations, the BarH family of homeodomain proteins play essential roles in cell fate specification, differentiation, migration, and survival. Barhl2, a member Barh gene family, is expressed retinal ganglion cells (RGCs), amacrine (ACs), horizontal cells. Here, to investigate role Barhl2 development, Barhl2-deficient mice were generated. Analysis AC subtypes retinas suggests that plays critical subtype determination. A significant reduction glycinergic GABAergic ACs...
Tian, Ning, Thomas N. Hwang, and David R. Copenhagen. Analysis of excitatory inhibitory spontaneous synaptic activity in mouse retinal ganglion cells. J. Neurophysiol. 80: 1327–1340, 1998. Spontaneous postsynaptic currents (sIPSCs sEPSCs) were identified characterized with whole cell perforated patch voltage-clamp recordings adult Pharmacological dissection revealed that all cells driven by inputs mediated glutamate γ-aminobutyric acid-A (GABA A ) receptors. One-half (7/14) the also received...
Abstract Recent studies showed that light stimulation is required for the maturational segregation of retinal ganglion cell (RGC) synaptic connectivity with ON and OFF bipolar cells in mammalian retina. However, it not clear to what extent regulates maturation RGC dendritic ramification connections. The present work quantitatively analyzed patterns different morphological subtypes RGCs developing mouse retinas demonstrated all four major underwent profound redistributions from center...
Abstract As the global population ages, research on pathogenesis and treatment options for older patients with dementia has become increasingly important. Vascular (VaD), second most frequent type of dementia, is characterized by vascular impairment caused inadequate blood supply to brain. VaD a complex neurological disorder involving multiple cells signaling pathways, its prevention pose clinical challenges significant behavioral implications. Glutamate, abundant amino acid in brain, plays...
Parallel ON and OFF pathways conduct visual signals from bipolar cells in the retina to higher centers brain. responses are thought originate by exclusive use of metabotropic glutamate receptor 6 (mGluR6) expressed retinal cells. Paradoxically, we find ganglion mGluR6-null mice, but they occur at long latency. The long-latency not blocked or cholinergic antagonists produced activation receptive field surrounds. We show that these longer-latency initiated pathways. Our results expose a...