A5073499106- Neuroscience and Neuropharmacology Research
- Retinal Development and Disorders
- Neural dynamics and brain function
- Photoreceptor and optogenetics research
- Functional Brain Connectivity Studies
- Axon Guidance and Neuronal Signaling
- Neuroscience and Neural Engineering
- Advanced MRI Techniques and Applications
- Neurobiology and Insect Physiology Research
- Nicotinic Acetylcholine Receptors Study
- Visual perception and processing mechanisms
- Receptor Mechanisms and Signaling
- Memory and Neural Mechanisms
- Advanced Fluorescence Microscopy Techniques
- Glaucoma and retinal disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- stochastic dynamics and bifurcation
- CRISPR and Genetic Engineering
- Neurogenesis and neuroplasticity mechanisms
- Nerve injury and regeneration
- Photochromic and Fluorescence Chemistry
- Hearing, Cochlea, Tinnitus, Genetics
- Neuroscience, Education and Cognitive Function
- Sleep and Wakefulness Research
- Cell Image Analysis Techniques
Yale University
2016-2025
Kavli Institute for Theoretical Sciences
2018-2020
Baylor College of Medicine
2000-2009
The University of Texas at Austin
2008
The University of Texas MD Anderson Cancer Center
2008
University of California, San Francisco
1995-2000
W. M. Keck Foundation
1997-2000
Foundation Center
1997-2000
Kyoto Prefectural University of Medicine
1993-1999
Kyoto University
1991-1997
The role of experience in the development cerebral cortex has long been controversial. Patterned visual cat begins when eyes open about a week after birth. Cortical maps for orientation and ocular dominance primary cats were found to be present by 2 weeks. Early pattern vision appeared unimportant because these cortical developed identically until nearly 3 weeks age, whether or not open. naı̈ve powerfully dominated contralateral eye, was needed responses other eye become strong, process...
Abstract Large-scale functional networks have been characterized in both rodent and human brains, typically by analyzing fMRI-BOLD signals. However, the relationship between underlying neural activity is complex incompletely understood, which poses challenges to interpreting network organization obtained using this technique. Additionally, most work has assumed a disjoint (i.e., brain regions belong one only network). Here, we employ wide-field Ca 2+ imaging simultaneously with mice...
Although it is widely accepted that molecular mechanisms play an important role in the initial establishment of retinotopic maps, has also long been argued activity-dependent factors act concert with to refine topographic maps. Evidence a for retinal activity map refinement mammals limited, and nothing known about effect spontaneous on development receptive fields superior colliculus. Using anatomical physiological methods two genetically manipulated mouse models pharmacological...
The maturation of retinal ganglion cell (RGC) axon projections in the dorsal lateral geniculate nucleus (dLGN) and superior colliculus (SC) relies on both molecular activity-dependent mechanisms. Despite increasing popularity mouse as a mammalian visual system model, little is known this species about normal development individual RGC arbors or role activity process. We used novel vivo single labeling technique to quantitatively characterize elaboration refinement dLGN SC wild-type (WT)...
The ability to perceive and respond environmental stimuli emerges in the absence of sensory experience. Spontaneous retinal activity prior eye opening guides refinement retinotopy eye-specific segregation mammals, but its role development higher-order visual response properties remains unclear. Here, we describe a transient window neonatal mouse during which spatial propagation spontaneous waves resembles optic flow pattern generated by forward self-motion. We show that wave directionality...
Spontaneous activity refines neural connectivity prior to the onset of sensory experience, but it remains unclear how such instructs axonal with subcellular precision. We simultaneously measured spontaneous retinal waves and individual retinocollicular axons tracked morphological changes in arbors across hours vivo neonatal mice. demonstrate that correlation an axon branch's neighboring or postsynaptic neurons predicts whether branch will be added, stabilized, eliminated. Desynchronizing...