A5041585906- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Neurotransmitter Receptor Influence on Behavior
- Memory and Neural Mechanisms
- Receptor Mechanisms and Signaling
- Photoreceptor and optogenetics research
- Ion channel regulation and function
- Cellular transport and secretion
- Neuroscience and Neural Engineering
- Retinal Development and Disorders
- Lipid Membrane Structure and Behavior
- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroendocrine regulation and behavior
- Psychedelics and Drug Studies
- Mitochondrial Function and Pathology
- Cannabis and Cannabinoid Research
- Genetics and Neurodevelopmental Disorders
- Neurological disorders and treatments
- Sleep and Wakefulness Research
- Nicotinic Acetylcholine Receptors Study
- Functional Brain Connectivity Studies
- Neurobiology and Insect Physiology Research
- Autism Spectrum Disorder Research
- Tryptophan and brain disorders
Stanford University
2016-2025
Palo Alto University
1982-2014
Howard Hughes Medical Institute
1998-2011
University of California, San Francisco
1993-2008
Stanford Medicine
2007
Cleveland Clinic
2006
Johns Hopkins Medicine
2006
University of California, Davis
2006
Louis Stokes Cleveland VA Medical Center
2006
Johns Hopkins University
2006
Activity-dependent modulation of synaptic efficacy in the brain contributes to neural circuit development and experience-dependent plasticity. Although glia are affected by activity ensheathe synapses, their influence on strength has largely been ignored. Here, we show that a protein produced glia, tumor necrosis factor α (TNFα), enhances increasing surface expression AMPA receptors. Preventing actions endogenous TNFα opposite effects. Thus, continual presence is required for preservation at...
Long-term potentiation and long-term depression (LTP/LTD) can be elicited by activating N-methyl-d-aspartate (NMDA)-type glutamate receptors, typically the coincident activity of pre- postsynaptic neurons. The early phases expression are mediated a redistribution AMPA-type receptors: More receptors added to potentiate synapse or removed weaken synapses. With time, structural changes become apparent, which in general require synthesis new proteins. investigation molecular cellular mechanisms...
The proinflammatory cytokine tumor necrosis factor-α (TNFα) causes a rapid exocytosis of AMPA receptors in hippocampal pyramidal cells and is constitutively required for the maintenance normal surface expression receptors. Here we demonstrate that TNFα acts on neuronal TNFR1 to preferentially exocytose glutamate receptor 2-lacking through phosphatidylinositol 3 kinase-dependent process. This increases excitatory synaptic strength while changing molecular stoichiometry Conversely, an...