A5055930126- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Neuroendocrine regulation and behavior
- Receptor Mechanisms and Signaling
- Stress Responses and Cortisol
- Circadian rhythm and melatonin
- Neurobiology and Insect Physiology Research
- Neural dynamics and brain function
- Photoreceptor and optogenetics research
- Zebrafish Biomedical Research Applications
- Sleep and Wakefulness Research
- Child and Adolescent Psychosocial and Emotional Development
- Nicotinic Acetylcholine Receptors Study
- Ion channel regulation and function
- Neuropeptides and Animal Physiology
- Neuroinflammation and Neurodegeneration Mechanisms
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Photochromic and Fluorescence Chemistry
- Cerebral Venous Sinus Thrombosis
- Mental Health Research Topics
- Molecular Communication and Nanonetworks
- Wnt/β-catenin signaling in development and cancer
- Cardiac, Anesthesia and Surgical Outcomes
- 14-3-3 protein interactions
- Obsessive-Compulsive Spectrum Disorders
University of California, Los Angeles
2020-2025
Stanford University
2012-2017
University of Calgary
2016
Palo Alto University
2016
National Institute of Mental Health
2016
Icahn School of Medicine at Mount Sinai
2016
Laureate Institute for Brain Research
2016
Massachusetts Institute of Technology
2016
Columbia University
2006-2011
Universidade de São Paulo
2006-2007
Acetylcholine (ACh) has been shown to modulate neuronal differentiation during early development. Both muscarinic and nicotinic acetylcholine receptors (AChRs) regulate a wide variety of physiological responses, including apoptosis, cellular proliferation differentiation. However, the intracellular mechanisms underlying these effects AChR signaling are not fully understood. It is known that activation AChRs increase neurogenesis regulation calcium through may underlie many functions ACh....
Abstract Homeotherms maintain a stable internal body temperature despite changing environments. During energy deficiency, some species can cease to defend their and enter hypothermic hypometabolic state known as torpor. Recent advances have revealed the medial preoptic area (MPA) key site for regulation of torpor in mice. The MPA is estrogen-sensitive estrogens also potent effects on both metabolism. Here, we demonstrate that neurons coordinate hypothermia hypometabolism Selectively...
Hippocampal CA1 place cell spatial maps are known to alter their firing properties in response contextual fear conditioning, a process called “remapping.” In the present study, we use chronic calcium imaging examine remapping during retrieval and extinction of an inhibitory avoidance task mice both sexes over extended period time with thousands neurons. We demonstrate that hippocampal ensembles encode space at finer scale following memory acquisition. This effect is strongest near shock...
Animals must balance needs to approach threats for risk assessment and avoid danger. The dorsal periaqueductal gray (dPAG) controls defensive behaviors, but it is unknown how represents states associated with threat avoidance. We identified a dPAG threatavoidance ensemble in mice that showed higher activity farther from such as the open arms of elevated plus maze predator. These cells were also more active during avoidance behaviors escape freezing, even though these have antagonistic motor...
During threat exposure, survival depends on defensive reactions. Prior works linked large glutamatergic populations in the midbrain periaqueductal gray (PAG) to freezing and flight, established that overarching functional organization axis of PAG is along anatomically-defined columns. Accordingly, broad activation dorsolateral column induces while lateral or ventrolateral (l vl) columns freezing. However, contains diverse cell types vary neurochemistry. How these contribute defense remains...
Abstract The neurophysiological mechanisms in the human amygdala that underlie post-traumatic stress disorder (PTSD) remain poorly understood. In a first-of-its-kind pilot study, we recorded intracranial electroencephalographic data longitudinally (over one year) two male individuals with electrodes implanted for management of treatment-resistant PTSD (TR-PTSD) under clinical trial NCT04152993. To determine electrophysiological signatures related to emotionally aversive and clinically...
The brainstem dorsal periaqueductal gray (dPAG) has been widely recognized as being a vital node orchestrating the responses to innate threats. Intriguingly, recent evidence also shows that dPAG mediates defensive fear conditioned contexts. However, it is unknown whether displays independent or shared patterns of activation during exposure and It unclear how ensembles encode predict diverse behaviors. To address this question, we used miniaturized microscopes obtain recordings same live...
Abstract Social hierarchies exert a powerful influence on behavior, but the neurobiological mechanisms that detect and regulate hierarchical interactions are not well understood, especially at level of neural circuits. Here, we use fiber photometry chemogenetic tools to record manipulate activity nucleus accumbens-projecting cells in ventromedial prefrontal cortex (vmPFC-NAcSh) during tube test social competitions. We show vmPFC-NAcSh projections signal learned relationships, selectively...