A5079071241- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Olfactory and Sensory Function Studies
- Sleep and Wakefulness Research
- Neurological Disorders and Treatments
- Neuropeptides and Animal Physiology
- Circadian rhythm and melatonin
- Receptor Mechanisms and Signaling
- Hemispheric Asymmetry in Neuroscience
- Photoreceptor and optogenetics research
- Evolutionary Psychology and Human Behavior
- Nicotinic Acetylcholine Receptors Study
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroendocrine regulation and behavior
- Stress Responses and Cortisol
University of California, Berkeley
2025
University of California, Los Angeles
2024
Stanford University
2013-2021
University of Michigan
2013-2016
The cortical cholinergic input system has been described as a neuromodulator that influences broadly defined behavioral and brain states. discovery of phasic, trial-based increases in extracellular choline (transients), resulting from the hydrolysis newly released acetylcholine (ACh), cortex animals reporting presence cues suggests ACh may have more specialized role cognitive processes. Here we expressed channelrhodopsin or halorhodopsin basal forebrain neurons mice with optic fibers...
The mechanisms by which the brain replays neural activity sequences remain unknown. Recording from large ensembles of hippocampal place cells in freely behaving rats, we observed that replay content is strictly organized over multiple timescales and governed self-avoidance. After movement cessation, avoided animal’s previous path for 3 seconds. Chains self-repetition a shorter timescale. We used continuous attractor model to demonstrate neuronal fatigue both generates produces self-avoidance...
Neural circuits generate representations of the external world from multiple information streams. The navigation system provides an exceptional lens through which we may gain insights about how such computations are implemented. in medial temporal lobe construct a map-like representation space that supports navigation. This computation integrates sensory cues, and, addition, is thought to require cues related individual's movement environment. Here, identify self-motion signals, position and...
Abstract Medial entorhinal cortex (MEC) supports a wide range of navigational and memory related behaviors. Well-known experimental results have revealed specialized cell types in MEC — e.g. grid, border, head-direction cells whose highly stereotypical response profiles are suggestive the role they might play supporting functionality. However, majority neurons do not exhibit firing patterns. How should these more “heterogeneous” be described, how contribute to behavior? In this work, we took...
Spontaneous neural activity sequences are generated by the brain in absence of external input
There is growing evidence to suggest cognitive impairment and adverse brain health outcomes are associated with chronic conditions such as diabetes, hypertension, cardiovascular disease (Barnes Bennet, 2014;Lock et al., 2023;Norris 2023). These can contribute dysfunction by disrupting physiological feedback mechanisms that regulate oxidative stress (Pugazhenthi 2017), causing fluctuations in systemic blood pressure (Wanleenuwat 2019), or promoting vasoconstriction impairs cerebral perfusion...
Summary The entorhinal cortex contains neural signals for representing self-location, including grid cells that fire in periodic locations and velocity encode an animal’s speed head direction. Recent work revealed the size shape of environment influences patterns. Whether are equally influenced or provide a universal metric self-motion across environments remains unknown. Here, we report changes to result re-scaling codes. Moreover, direction re-organize experience-dependent manner align...