A5103060674- Melanoma and MAPK Pathways
- Colorectal Cancer Treatments and Studies
- Plant biochemistry and biosynthesis
- Tea Polyphenols and Effects
- Fermentation and Sensory Analysis
- Cancer Mechanisms and Therapy
- Ubiquitin and proteasome pathways
- Wnt/β-catenin signaling in development and cancer
- Plant Gene Expression Analysis
- Cancer Research and Treatments
- Cancer-related gene regulation
- Cell Adhesion Molecules Research
- Phytochemicals and Antioxidant Activities
- Plant Stress Responses and Tolerance
- Food Quality and Safety Studies
- Cancer-related Molecular Pathways
- Peptidase Inhibition and Analysis
- Cellular Mechanics and Interactions
- Pancreatic and Hepatic Oncology Research
- Cell Image Analysis Techniques
- PI3K/AKT/mTOR signaling in cancer
- Nuts composition and effects
- Hippo pathway signaling and YAP/TAZ
- Genetic Mapping and Diversity in Plants and Animals
- Protein Degradation and Inhibitors
Yangtze Normal University
2025
Brigham and Women's Hospital
2024-2025
Tianjin University
2025
Nanjing University of Aeronautics and Astronautics
2025
Johns Hopkins University
2025
UPMC Hillman Cancer Center
2010-2024
University of Pittsburgh
2010-2024
Nanjing Medical University
2024
Fujian Agriculture and Forestry University
2022-2024
Beijing University of Chinese Medicine
2024
Abscisic Acid (ABA) is an important phytohormone involved in abiotic stress resistance plants. A group of bZIP transcription factors play roles the ABA signaling pathway Arabidopsis. However, little known about function their orthologs rice, where they may hold a great potential for developing drought resistant food crops. In this study, our phylogenetic analysis showed that bZIPs was evolutionarily conserved between Arabidopsis and which implies share similar functions. We demonstrated with...
The canonical Wnt signaling pathway (or Wnt/β-catenin pathway) plays a pivotal role in embryonic development and adult homeostasis; deregulation of the contributes to initiation progression human diseases including cancer. Despite its importance biology disease, how regulation is achieved remains largely undefined. Increasing evidence suggests that post-translational modifications (PTMs) components are essential for activation pathway. PTMs create highly dynamic relay system responds...
Bacterial infection and excess reactive oxygen species are key factors that lead to slow or substantially delayed wound healing. It is crucial design develop new nanomaterials with antibacterial antioxidative capabilities for Here, positively charged carbon dots (CDs) rationally designed synthesized from p-phenylenediamine polyethyleneimine by a facile one-pot solvothermal method, which show good biocompatibility in vitro cytotoxicity, hemolysis assays, vivo toxicity evaluation. The CDs...
Aberrant activation of Wnt/β-catenin signaling plays an unequivocal role in colorectal cancer, but identification effective Wnt inhibitors for use cancer remains a tremendous challenge. New insights into the regulation this pathway could reveal new therapeutic point intervention, therefore are greatly needed. Here we report novel FAK/PYK2/GSK3βY216/β-catenin axis: FAK and PYK2, elevated adenomas APCmin/+ mice human tissues, functioned redundantly to promote by phosphorylating GSK3βY216...
Abstract Genomic DNA is folded into a higher-order structure that regulates transcription and maintains genomic stability. Although progress has been made on understanding biochemical characteristics of epigenetic modifications in cancer, the in-situ folding chromatin during malignant transformation remains largely unknown. Here, using optimized stochastic optical reconstruction microscopy (STORM) for pathological tissue (PathSTORM), we uncover gradual decompaction fragmentation throughout...
Abstract One of the most encouraging developments in oncology has been success BRAF inhibitors BRAF-mutant melanoma. However, contrast to its striking efficacy melanomas, inhibitor monotherapy is ineffective colorectal cancer. Although many studies on resistance cancer have focused mechanisms underlying reactivation EGFR/RAS/RAF/MEK/ERK pathway, current study focuses identifying novel adaptive signaling mechanisms, a fresh angle inhibition. We found that treatment with (both and...
To improve the efficiency and effectiveness of mosaicking unmanned aerial vehicle (UAV) images, we propose in this paper a rapid method based on scale-invariant feature transform (SIFT) for UAV images used crop growth monitoring. The proposed dynamically sets appropriate contrast threshold difference Gaussian (DOG) scale-space according to characteristics Therefore, adjusts optimizes number matched point pairs increases efficiency. Meanwhile, relative location relationship monitoring, random...
There is increasing interest in the production and consumption of tea (Camellia sinensis L.) processed from purple–leaved cultivar due to their high anthocyanin content health benefits. However, how why seasonal changes affect accumulation young leaves still remains obscured. In this study, abscisic acid (ABA) contents Zifuxing 1 (ZFX1), a with new shoots turning purple Wuyi Mountain, key region China, were monitored over four seasons. Young produced September highly purplish, which was...
The aim of this study is to assess the accuracy Chat Generative Pretrained Transformer (ChatGPT) in response oncology examination questions setting one-shot learning. Consecutive national radiation in-service multiple-choice examinations were collected and inputted into ChatGPT 4o 3.5 determine ChatGPT's answers. answers then compared with answer keys whether correctly or incorrectly answered each question if improvements responses seen newer version. A total 600 consecutive ChatGPT. 72.2%...
About 76% of patients with lung adenocarcinoma harbor activating mutations in the receptor tyrosine kinase (RTK)/RAS/RAF pathways, leading to aberrant activation mitogen-activated protein (MAPK) pathways particularly MAPK/ERK pathway. However, many adenocarcinomas lacking these genomic also display significant MAPK pathway activation, suggesting that additional alterations remain undetected. This study has identified serine/threonine 4 (MAP4K4) as a novel positive regulator signaling...
This retrospective study uses electronic health record data to investigate the sex differences in guideline-based management outcomes between male and female patients with chronic kidney disease.
Drought stress affects the growth and productivity of crop plants including sorghum. To study molecular basis drought tolerance in sorghum, we conducted transcriptomic profiling sorghum leaves roots under using RNA-Seq method. A total 510, 559, 3 687 differentially expressed genes (DEGs) leaves, 368, 5 093, 4 635 DEGs responding to mild drought, severe re-watering treatments were identified, respectively. Among them, 190 common 1 644 responsive environment. Gene Ontology (GO) enrichment...
Panyong Congou black tea (PCT) is one of the most representative and historically famous teas in China has been gaining more attention for its beneficial health properties. Currently, four grades PCT are available, based on raw leaf materials consumer palatability. The chemical profiles distinguishing different yet to be defined, nor relationship with grade evaluated. In present study, chemometric analysis showed that epigallocatechin (EGC), catechin (C), polyphenols, gallic acid (GA), free...
Objective Tongue segmentation as a basis for automated tongue recognition studies in Chinese medicine, which has defects such network degradation and inability to obtain global features, seriously affects the effect. This article proposes an improved model RTC_TongueNet based on DeepLabV3, combines residual structure transformer integrates ECA (Efficient Channel Attention Module) attention mechanism of multiscale atrous convolution improve effect image segmentation. Methods In this paper, we...
A pivotal step in canonical Wnt signaling is Wnt-induced β-catenin stabilization. In the absence of Wnt, targeted for β-transducin repeats-containing proteins (β-TrCP)-mediated degradation due to phosphorylation by glycogen synthase kinase 3 (Gsk3). How regulates Gsk3 inhibit proteolysis remains largely elusive. This study reveals novel key molecular events signaling: induction Gsk3β ubiquitination and Gsk3β-β-TrCP binding. We found that stimulation induced prolonged monoubiquitination...
The road adhesion coefficient is an important parameter that affects the acceleration, steering, and braking performance of vehicles. Accurately estimating can ensure vehicle active safety systems reduce risk accidents such as rear-end collisions skidding during operation. Existing estimation methods do not take into account overfitting problem easily caused by high dimensionality features, well degradation accuracy due to different intervals superiority a single model structure. To address...