A5104032911- Cardiovascular Function and Risk Factors
- Cancer, Hypoxia, and Metabolism
- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- Cardiomyopathy and Myosin Studies
- Genetic Associations and Epidemiology
- Thyroid Disorders and Treatments
- Lipoproteins and Cardiovascular Health
- Coronary Interventions and Diagnostics
- Liver Disease Diagnosis and Treatment
- Antiplatelet Therapy and Cardiovascular Diseases
- Lung Cancer Treatments and Mutations
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Cancer Cells and Metastasis
- Cardiovascular Effects of Exercise
- Congenital Heart Disease Studies
- Artificial Intelligence in Healthcare and Education
- Diabetes Treatment and Management
- Cardiovascular Disease and Adiposity
- Pancreatic function and diabetes
- ECG Monitoring and Analysis
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Systems, Economic Evaluations, Quality of Life
- Cardiac, Anesthesia and Surgical Outcomes
- Non-Invasive Vital Sign Monitoring
Peking University
2020-2025
Peking University Third Hospital
2021-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2010-2024
Fu Wai Hospital
2020-2024
State Key Laboratory of Cardiovascular Disease
2021-2024
Center for Vascular Biology Research
2024
Peking Union Medical College Hospital
2010-2022
Ministry of Education of the People's Republic of China
2021-2022
Guangdong Provincial People's Hospital
2022
Guangdong Academy of Medical Sciences
2022
Abstract Aldehyde dehydrogenase (ALDH) is a candidate marker for lung cancer cells with stem cell-like properties. Immunohistochemical staining of large panel primary non–small cell (NSCLC) samples ALDH1A1, ALDH3A1, and CD133 revealed significant correlation between ALDH1A1 (but not ALDH3A1 or CD133) expression poor prognosis in patients including those stage I N0 disease. Flow cytometric analysis lines patient tumors that most NSCLCs contain subpopulation elevated ALDH activity, this...
Aggressive neuroendocrine lung cancers, including small cell cancer (SCLC) and non-small (NSCLC), represent an understudied tumor subset that accounts for approximately 40,000 new cases per year in the United States. No targeted therapy exists these tumors. We determined achaete-scute homolog 1 (ASCL1), a transcription factor required proper development of pulmonary cells, is essential survival majority cancers (both SCLC NSCLC) with features. By combining whole-genome microarray expression...
In recent years, some studies have indicated that a novel marker described as the stress hyperglycemia ratio (SHR) can reflect true acute hyperglycemic status and is associated with short-term poor prognosis in patients myocardial infarction. current study we evaluated association of SHR adverse cardiovascular events among coronary syndrome (ACS).We consecutively enrolled 5,562 ACS who underwent drug-eluting stent (DES) implantation. All subjects were divided into five groups according to...
Abstract Background Non-diabetic coronary artery disease (CAD) patients are thought to encounter metabolic dysfunction and while these changes may be imperceptible the patient they probably influence outcomes. At present, there is no system support sensing subtle changes, nor an established model for prognoses. The Atherogenic Index of Plasma (AIP) index has already proven useful atherosclerosis although further research needed, especially those without hyperglycemia. Methods This a...
The impact of insulin resistance on the prognosis heart failure with preserved ejection fraction (HFpEF) remains unknown. This study aimed to investigate association between triglyceride-glucose (TyG) index, an easily calculated marker resistance, and long-term HFpEF.A total 823 patients HFpEF were enrolled in study. TyG index was determined using formula ln(fasting triglycerides [mg/dL] × fasting glucose [mg/dL]/2). primary endpoint all-cause death. secondary endpoints cardiovascular (CV)...
Abstract Background The relationship between stress hyperglycemia and long-term prognosis in acute decompensated heart failure (ADHF) patients is unknown. This study investigated the associations of with mortality rehospitalization rates among ADHF diabetes. Methods We consecutively enrolled 1904 patients. Among them, 780 were Stress was estimated using ratio (SHR), which calculated by following formula: SHR = admission blood glucose/[(28.7 × HbA1c%) – 46.7]. All diabetic subjects divided...
Patients undergoing percutaneous coronary intervention react differently to antiplatelet drugs. Those with low responsiveness clopidogrel have a higher risk of cardiac ischemic events. The goal this study is conduct head-to-head comparison the safety and effectiveness intensified therapies (either double-dose [DOUBLE] or adjunctive cilostazol [TRIPLE]) conventional strategy (STANDARD) in patients after intervention.In single-center, randomized, controlled trial, we used thromboelastography,...
Abstract Background Familial hypercholesterolemia (FH) is an inherited metabolic disorder with a high level of low-density lipoprotein cholesterol and the worse prognosis. The triglyceride-glucose (TyG) index, emerging tool to reflect insulin resistance (IR), positively associated higher risk atherosclerotic cardiovascular disease (ASCVD) in healthy individuals, but value TyG index has never been evaluated FH patients. This study aimed determine association between glucose indicators, (IR)...
Arrhythmia is a common problem of irregular heartbeats, which may lead to serious complications such as stroke and even mortality. Due the paroxysmal nature arrhythmia, its long-term monitoring early detection in daily household scenarios, instead depending on ECG examination only available during clinical visits, are critical importance. While ambulatory Holter wearables like smartwatches have been used, they still inconvenient interfere with users' activities. In this paper, we bridge gap...
Background The triglyceride-glucose index (TyG index) is a valuable marker for predicting adverse cardiovascular events in diabetic patients. However, nondiabetic patients, whether the TyG independently related to poor prognosis remains unclear. This cohort study assessed association of with future risk subjects who received percutaneous coronary intervention (PCI). Methods We consecutively enrolled 5,489 patients underwent PCI. All experimental were divided into three groups based on their...
Abstract Background: Thyroid dysfunction is associated with cardiovascular diseases. However, the role of thyroid function in lipid metabolism remains partly unknown. The present study aimed to investigate causal association between and serum via a genetic analysis termed Mendelian randomization (MR). Methods: MR approach uses variant as instrumental variable epidemiological studies mimic randomized controlled trial. A two-sample was performed assess association, using summary statistics...
Background Aficamten, a novel cardiac myosin inhibitor, reversibly reduces hypercontractility in obstructive hypertrophic cardiomyopathy. We present prespecified analysis of the pharmacokinetics, pharmacodynamics, and safety aficamten SEQUOIA‐HCM (Safety, Efficacy, Quantitative Understanding Obstruction Impact Aficamten HCM). Methods Results A total 282 patients with cardiomyopathy were randomized 1:1 to daily (5–20 mg) or placebo between February 1, 2022, May 15, 2023. dosing targeted...
Abstract Background Despite the World Health Organization's prioritization of familial hypercholesterolemia (FH), its global diagnostic rate remains critically low, leading to inadequate treatment and control, thereby increasing risk atherosclerotic cardiovascular disease. This study aimed investigate comorbidity burden FH in China analyze differences between general (HC) populations. Methods Using a national medical insurance database from 2013 2017 including 13,976 patients with matched...
MAPK pathways regulate transcription through phosphorylation of factors and other DNA-binding proteins. In pancreatic beta-cells, ERK1/2 are required for the insulin gene several genes in response to glucose. We show that binding glucose-sensitive activators repressors promoter depends on activity. also find glucose NGF stimulate promoters. An cascade module, including MEK1/2 Rsk, found complexes bound these These findings imply MAPK-containing signaling positioned sensitive promoters with...
Background: For anaphylaxis, a life-threatening allergic reaction, the incidence rate was presented to have increased from beginning of 21st century. Underdiagnosis and undertreatment anaphylaxis are public health concerns. Objective: This guideline aimed provide high-quality evidence-based recommendations for emergency management anaphylaxis. Method: The panel professionals fifteen medical areas selected twenty-five clinical questions formulated with supervision four methodologists. We...
Abstract Aims Recent studies suggested that both left ventricular ejection fraction (LVEF) lower than 60% or higher 65% were associated with an increased mortality in the general population. Uncertainty remains regarding adverse outcomes across LVEF coronary artery disease (CAD). The common understanding was <40% risk of mortality. But threshold at 40% arbitrary because quite a lot existed patients >40%. We aimed to evaluate relationship between and events CAD undergoing percutaneous...
Abstract Background Limited research has been conducted on the potential relationship between dietary inflammation index (DII) and mortality, particularly in individuals with Helicobacter pylori (H. pylori) infection. This study aimed to investigate association DII H. infection, as well their respective impacts all-cause mortality a cohort of or without Methods Data from 1999–2018 National Health Nutrition Examination Survey (NHANES) were utilized for this study, final 4370 participants...
We report a randomized, multicenter, open-label trial (ClinicalTrials.gov: NCT03096613) to investigate the clinical benefits of levothyroxine (L-T4) administration in subclinical hypothyroidism (SCH) patients with heart failure reduced ejection fraction (HFrEF). Overall, 117 were enrolled and received L-T4 plus standard HFrEF treatment (experimental group, N = 57) or therapy alone (control 60). The change 6-min walk test distance experimental group was significantly higher than that control...
The electrocardiogram (ECG) has always served as a crucial biomedical examination for cardiac diseases monitoring and diagnosing. Typical ECG measurement requires attaching electrodes to the body, which is inconvenient long-term monitoring. Recent wireless sensing maps signals reflected from human chest into electrical activities of heart so reconstruct contactlessly. While making great progress, we find existing works are effective only healthy populations with normal ECG, but fall short...
Large language models (LLMs) are rapidly advancing medical artificial intelligence, offering revolutionary changes in health care. These excel natural processing (NLP), enhancing clinical support, diagnosis, treatment, and research. Breakthroughs, like GPT-4 BERT (Bidirectional Encoder Representations from Transformer), demonstrate LLMs’ evolution through improved computing power data. However, their high hardware requirements being addressed technological advancements. LLMs unique...