Frank Edelmann
A5008989410- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Cardiovascular and exercise physiology
- Cardiac Imaging and Diagnostics
- Cardiac pacing and defibrillation studies
- Cardiac Health and Mental Health
- Cardiac electrophysiology and arrhythmias
- Atrial Fibrillation Management and Outcomes
- Hormonal Regulation and Hypertension
- Cardiac Structural Anomalies and Repair
- Cardiac Valve Diseases and Treatments
- Diabetes Treatment and Management
- Cardiovascular Effects of Exercise
- Blood Pressure and Hypertension Studies
- Cardiovascular Disease and Adiposity
- Advanced MRI Techniques and Applications
- Erythropoietin and Anemia Treatment
- Electrolyte and hormonal disorders
- Cardiac Arrhythmias and Treatments
- Metabolomics and Mass Spectrometry Studies
- Diet and metabolism studies
- Health Systems, Economic Evaluations, Quality of Life
- GDF15 and Related Biomarkers
- Cardiomyopathy and Myosin Studies
- Nutrition and Health in Aging
German Centre for Cardiovascular Research
2016-2025
Charité - Universitätsmedizin Berlin
2016-2025
Humboldt-Universität zu Berlin
2020-2025
Freie Universität Berlin
2020-2025
Deutsches Herzzentrum der Charité
2019-2025
Universitätsmedizin Göttingen
2011-2025
Sequoia (United States)
2024
SEQUOIA (Italy)
2024
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2017-2024
Deutsches Herzzentrum München
2023-2024
Abstract Making a firm diagnosis of chronic heart failure with preserved ejection fraction (HFpEF) remains challenge. We recommend new stepwise diagnostic process, the ‘HFA–PEFF algorithm’. Step 1 (P=Pre-test assessment) is typically performed in ambulatory setting and includes assessment for HF symptoms signs, typical clinical demographics (obesity, hypertension, diabetes mellitus, elderly, atrial fibrillation), laboratory tests, electrocardiogram, echocardiography. In absence overt...
Poland), and Katja Zeppenfeld (
Diastolic heart failure (ie, with preserved ejection fraction) is a common condition without established therapy, and aldosterone stimulation may contribute to its progression.To assess the efficacy safety of long-term receptor blockade in fraction. The primary objective was determine whether spironolactone superior placebo improving diastolic function maximal exercise capacity patients fraction.The Aldo-DHF trial, multicenter, prospective, randomized, double-blind, placebo-controlled trial...
<h3>Importance</h3> Depression is frequent in patients with heart failure and associated adverse clinical outcomes. Long-term efficacy safety of selective serotonin reuptake inhibitors these are unknown. <h3>Objective</h3> To determine whether 24 months treatment escitalopram improves mortality, morbidity, mood chronic systolic depression. <h3>Design, Setting, Participants</h3> The Effects Selective Serotonin Re-Uptake Inhibition on Morbidity, Mortality, Mood Depressed Heart Failure Patients...
Cardiovascular Magnetic Resonance myocardial feature tracking (CMR-FT) is a quantitative technique tissue voxel motion on standard steady-state free precession (SSFP) cine images to assess ventricular deformation. The importance of left atrial (LA) deformation assessment increasingly recognized and can be assessed with echocardiographic speckle tracking. However quantification has never previously been demonstrated CMR. We sought determine the feasibility reproducibility CMR-FT for...
This study sought to confirm a subgroup analysis of the prior FIX-HF-5 (Evaluate Safety and Efficacy OPTIMIZER System in Subjects With Moderate-to-Severe Heart Failure) showing that cardiac contractility modulation (CCM) improved exercise tolerance (ET) quality life patients with ejection fractions between 25% 45%.CCM therapy for New York Association (NYHA) functional class III IV heart failure (HF) consists nonexcitatory electrical signals delivered during absolute refractory period.A total...
<h3>Importance</h3> Endurance exercise is effective in improving peak oxygen consumption (peak V̇o<sub>2</sub>) patients with heart failure preserved ejection fraction (HFpEF). However, it remains unknown whether differing modes of have different effects. <h3>Objective</h3> To determine high-intensity interval training, moderate continuous and guideline-based advice on physical activity effects change V̇o<sub>2</sub>in HFpEF. <h3>Design, Setting, Participants</h3> Randomized clinical trial...
Background and Purpose— Diagnosis of paroxysmal atrial fibrillation is difficult but highly relevant in patients presenting with cerebral ischemia yet free from on admission. Early initiation prolongation continuous Holter monitoring may improve diagnostic yield compared the standard care including a 24-hour recording. Methods— In observational Find-AF trial (ISRCTN 46104198), consecutive symptoms were included. Patients at presentation received 7-day monitoring. Results— Two hundred...
The aim of the present multicentre study was to analyse a large cohort healthy subjects and patients with common condition such as heart failure (HF) purpose determining normal range usefulness right ventricular (RV) systolic strain detect subtle RV abnormalities using 2D speckle-tracking echocardiography.We analysed 238 642 characterized by asymptomatic (n = 216) HF preserved (HFpEF) reduced (HFrEF) ejection fraction 218 n 208, respectively) prospectively included in 10 centres. analysing...
Heart failure with normal ejection fraction (HFnEF) is an important clinical entity that remains incompletely understood. The novel biomarker growth differentiation factor 15 (GDF-15) elevated in systolic heart (HFrEF) and predictive of adverse outcome. We investigated the relevance GDF-15 plasma levels HFnEF.A subgroup patients from ongoing DIAST-CHF observational trial, a history chronic (CHF) or positive Framingham criteria at presentation, was selected. Patients were classified as having...
Hyperglycaemia and insulin resistance have been linked to diastolic dysfunction experimentally. We investigated the association between glucose metabolism function along whole spectrum of states. In observational Diagnostic Trial on Prevalence Clinical Course Diastolic Dysfunction Heart Failure (DIAST-CHF) study, patients with risk factors for heart failure were included. analysed data including comprehensive echocardiography from a subgroup classified by OGTT history as normal (n = 343),...
General self-efficacy has been found to be an influential variable related the adaptation stress and chronic illness, with Self-Efficacy (GSE) Scale by Jerusalem Schwarzer being a reliable valid instrument assess this disposition. The aim of study was construct test short form scale allow for more economical assessment construct.The item characteristics original were assessed using intercultural non-clinical sample (n=19,719). Six items highest coefficient variation good discrimination along...
Abstract Aims To investigate the effects of spironolactone on fibrosis and cardiac function in people at increased risk developing heart failure. Methods results Randomized, open-label, blinded-endpoint trial comparing (50 mg/day) or control for up to 9 months with, high of, coronary disease raised plasma B-type natriuretic peptides. The primary endpoint was interaction between baseline serum galectin-3 changes procollagen type-III N-terminal pro-peptide (PIIINP) participants assigned...
Understanding the genetic architecture of cardiac structure and function may help to prevent treat heart disease. This investigation sought identify common variations associated with inter-individual variability in function.