A5101923484- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- RNA Research and Splicing
- Cardiac Arrest and Resuscitation
- Cancer, Hypoxia, and Metabolism
- Mechanical Circulatory Support Devices
- HER2/EGFR in Cancer Research
- Cancer Immunotherapy and Biomarkers
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Cannabis and Cannabinoid Research
- Cancer, Lipids, and Metabolism
- Radiomics and Machine Learning in Medical Imaging
- Neuroscience and Neuropharmacology Research
- Machine Learning in Healthcare
- Nanoplatforms for cancer theranostics
- Acute Myeloid Leukemia Research
- Reproductive System and Pregnancy
- Plant Stress Responses and Tolerance
- Pharmacological Receptor Mechanisms and Effects
- Microscopic Colitis
- Gut microbiota and health
- Pharmacological Effects of Natural Compounds
- Nutritional Studies and Diet
Nanjing Medical University
2016-2025
Zhengzhou University
2021-2025
Sichuan University
2021-2025
West China Hospital of Sichuan University
2021-2025
Chengdu University of Traditional Chinese Medicine
2025
First Affiliated Hospital of Zhengzhou University
2019-2025
Children's Hospital of Zhejiang University
2025
Brigham and Women's Hospital
2024
Harvard University
2024
Amazon (United States)
2024
Abstract Sigma‐1 receptor (S1R) regulates reactive oxygen species (ROS) accumulation via nuclear factor erythroid 2‐related 2 (NRF2), which plays a vital role in ferroptosis. Sorafenib is strong inducer of ferroptosis but not apoptosis. However, the mechanism sorafenib‐induced hepatocellular carcinoma (HCC) remains unclear. In this study, we found for first time that sorafenib induced most S1Rs away from nucleus compared to control groups Huh‐7 cells, and ferrostatin‐1 completely blocked...
Abstract Sorafenib is currently the only systemic agent approved for treatment of advanced hepatocellular carcinoma (HCC). However, intrinsic and acquired resistance to sorafenib remains a great challenge with respect improving prognoses patients HCC. The cyto-protective functions autophagy have been suggested as potential mechanism by which chemoresistance or targeted drug occurs in tumour cells. In present study, miR-142-3p was identified novel autophagy-regulating microRNA (miRNA) that...
Previous studies report that lipopolysaccharide (LPS)-preconditioned mesenchymal stem cells have enhanced trophic support and improved regenerative repair properties. Extracellular vesicles secreted by synovial (EVs) can reduce cartilage damage caused osteoarthritis (OA). show extracellular LPS-preconditioned (LPS-pre EVs) improve the response to treatment of This study sought explore effects LPS-pre EVs on chondrocyte proliferation, migration, apoptosis, as well protective effect mouse...
Recently, several molecular subtypes with different prognosis have been found in lung adenocarcinoma (LUAD). However, the characteristics of ferroptosis and associated tumor microenvironment (TME) cell infiltration not fully studied LUAD. Using 1160 samples, we explored mediated by ferroptosis-related genes, along TME infiltration. The score was constructed using least absolute shrinkage selection operator regression (LASSO) method to quantify a single tumor. Three related ferroptosis,...
Abstract Background Familial hypercholesterolemia (FH) is an inherited metabolic disorder with a high level of low-density lipoprotein cholesterol and the worse prognosis. The triglyceride-glucose (TyG) index, emerging tool to reflect insulin resistance (IR), positively associated higher risk atherosclerotic cardiovascular disease (ASCVD) in healthy individuals, but value TyG index has never been evaluated FH patients. This study aimed determine association between glucose indicators, (IR)...
There is a paucity of literature about prognostic evaluation for patients with breast cancer (BC) and bone metastasis at presentation. To date, little known how to accurately predict the prognosis BC Thus, an accurate prediction tool in this population urgently needed. Our goal construct novel nomograms presentation.We searched Surveillance, Epidemiology, End Results (SEER) database presentation between 2010 2016. Multivariate analysis was performed obtain significantly independent...
Curcumin, a phytochemical from rhizomes of the plant Curcuma longa, has been reported to exert potential anticancer properties in various cancer types, including acute myeloid leukemia (AML). However, underlying mechanism remains poorly understood. The present study demonstrated that curcumin had stronger cytotoxic activity against AML cells compared with three other types phytochemicals (epigallocatechin gallate, genistein and resveratrol). Protein phosphorylation profiling using an...
Abstract Programmed death-ligand 1 (PD-L1) ensures that tumor cells escape T-cell-mediated immune surveillance. However, gliomas are characteristic of the low response and high-resistance therapy, it is necessary to understand molecular regulatory mechanisms in glioblastoma, especially limited regulation PD-L1 expression. Herein, we show expression AP-2α correlated with high high-grade glioma tissues. binds directly promoter CD274 gene, not only inhibits transcriptional activity but enhances...
Reduced expression of thyroid hormone receptors (TRs) has been observed in various human malignancies, though its predictive value hepatocellular carcinoma (HCC) remains uncertain. To explore the TRs patients with carcinoma. The design was bioinformatic analysis combined experimental study. This study utilized Kaplan-Meier TR profiles from Cancer Genome Atlas (TCGA). Expression levels HCC and immune single cells were assessed using datasets Gene Omnibus (GEO) TCGA, analyzed R software. Cox...
Myocardial ischemia-reperfusion injury (MIRI) often leads to irreversible myocardium dysfunction, while existing therapies are palliatives that transiently alleviate the disease symptoms. Repairing sarcoplasmic reticulum Ca 2+ -ATPase (SERCA) could reverse MIRI, which, however, requires precise drug delivery (SR). To this end, we leverage cell-cell “NETwork” of neutrophils deliver SERCA activator-loaded SR-localized nanoparticles (L-P-NPs) damaged myocardial cells, following a hierarchical...
Intracranial hemorrhage (ICH), a severe complication among adults receiving extracorporeal membrane oxygenation (ECMO), is often related to poor outcomes. This study aimed establish predictive model for ICH in ECMO treatment. Adults who received between January 2017 and June 2022 were the subjects of single-center retrospective study. Patients under age 18 years old, with acute before ECMO, less than 24 h support, incomplete data excluded. was diagnosed by head computed tomography scan. The...
The gene encoding the tumor suppressor p53 is most frequently mutated in cancers. However, mutation rare acute myeloid leukemia (AML), and inactivated predominantly by aberrant expression of regulators (such as MDM2). A previous study authors revealed that ZCCHC10 protein suppressed MDM2‑mediated degradation lung cancer. role AML have not been investigated. In present study, it was found downregulated bone marrow samples patients significantly negatively correlated with lncRNA SNHG1....
BACKGROUND: BMP9 (bone morphogenetic protein 9) is a member of the TGF-β (transforming growth factor β) family cytokines with pleiotropic effects on glucose metabolism, fibrosis, and lymphatic development. However, role in myocardial infarction (MI) remains elusive. METHODS: The expressional profiles cardiac tissues plasma samples subjects MI were determined by immunoassay or immunoblot. was evaluating impact deficiency replenishment adeno-associated virus–mediated expression recombinant...
Background With the establishment of cardiac-gut axis concept, increasing evidence has suggested involvement and important regulatory role gut microbiota (GM) short chain fatty acid (SCFA) in cardiovascular diseases. However, relationship between GM atrial fibrillation (AF) is still poorly understood. Objectives The aim this study was to investigate whether there were differences SCFA AF patients healthy controls. Methods In study, we enrolled 30 hospitalized with matched sinus rhythm (SR)....
Eosinophils, a type of white blood cell originating from the bone marrow, are widely believed to play crucial role in inflammatory processes, including allergic reactions and parasitic infections. However, relationship between eosinophils liver cancer is not well understood.