A5047779761- RNA Research and Splicing
- RNA modifications and cancer
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Ubiquitin and proteasome pathways
- Genomics and Chromatin Dynamics
- NF-κB Signaling Pathways
- Cell Adhesion Molecules Research
- Cancer-related Molecular Pathways
- Microtubule and mitosis dynamics
- DNA Repair Mechanisms
- Spine and Intervertebral Disc Pathology
- RNA Interference and Gene Delivery
- Spinal Fractures and Fixation Techniques
- Genetics and Neurodevelopmental Disorders
- Medical Imaging and Analysis
- Osteoarthritis Treatment and Mechanisms
- CRISPR and Genetic Engineering
- interferon and immune responses
- Bone Metabolism and Diseases
- Immunotherapy and Immune Responses
- Histone Deacetylase Inhibitors Research
- Inflammatory mediators and NSAID effects
- RNA and protein synthesis mechanisms
- Exercise and Physiological Responses
Hunan Normal University
2014-2024
Wuhan University
2006-2024
Renmin Hospital of Wuhan University
2006-2024
Cornell University
2023
Bridge University
2023
Affiliated Hospital of Youjiang Medical University for Nationalities
2023
Guangxi Medical University
2023
Fudan University
2023
Vulcan (United States)
2022
Fujian Medical University
2018
Hepatocellular carcinoma (HCC) is one of the most common and lethal types cancer. This study aimed to identify expression regulatory network a prognostic signature HCC. RNA-seq data from The Cancer Genome Atlas were used differentially expressed genes (DEGs) between HCC normal liver tissues. DEGs subjected construction protein-protein interaction (PPI) enrichment analysis Gene Ontology terms Kyoto Encyclopedia Genes Genomes pathways. results showed that enriched in cell cycle pathway, top 10...
Summary Objectives To investigate the relationship between serum sclerostin level, body composition, and bone mineral density (BMD) in central south Chinese postmenopausal women. Methods A cross‐sectional study was conducted on 260 healthy southern women with vs without osteoporosis, aged 50–76 years old. Dual X‐ray absorptiometry used to measure content BMD of whole body, lumbar spine left femur, total soft tissue composition. Serum levels were measured by a quantitative sandwich...
Highlights•mTORC1 is a potent regulator of white to beige adipogenesis•mTORC1 inhibition leads WAT browning and occurs despite sympathetic denervation•COX-2 prostaglandins are essential for in Raptor-deficient mice•mTORC1 suppresses COX-2/PG pathway via CRTC2-dependent mechanismSummaryBeige adipocytes present adipose tissue (WAT) have thermogenic capacity orchestrate substantial energy metabolism counteract obesity. However, adipocyte-derived signals that act on progenitor cells control...
The transcription factor AP-2α functions as a tumor suppressor by regulating various genes that are involved in cell proliferation and apoptosis. Chemotherapeutic drugs including cisplatin induce post-transcriptionally endogenous AP-2α, which contributes to chemosensitivity enhancing therapy-induced microRNAs (miRNAs) miR-200b, miR-200c miR-429 (miR-200b/200c/429) up-regulated endometrial esophageal cancers, their overexpression correlates with resistance treatment. Using computational...
Ferroptosis is a form of regulated cell death (RCD) triggered by iron-dependent lipid peroxidation and closely associated with the occurrence progression hepatocellular carcinoma (HCC). The lncRNA SNHG1 (small nucleolar RNA host gene 1) has been shown to play an oncogenic role in HCC, but its function RCD other than autophagy apoptosis still unknown. Here, we investigated correlation between 156 typical markers five types based on sequencing data from Cancer Genome Atlas database showed...
Abstract AP‐2 is a transcription factor implicated in mammalian development, cell proliferation, apoptosis, and carcinogenesis. To identify potential AP‐2α‐interacting partners, yeast two‐hybrid screen was performed human brain cDNA library. One of the identified clones encodes potassium channel tetramerization domain‐containing 1 (KCTD1). We demonstrated novel KCTD1–AP‐2α interaction vitro by GST pull‐down assays vivo co‐immunoprecipitation mapped domains to N‐termini both proteins. In...
The role of microRNAs (miRNAs) in regulating gene expression is currently an area intense interest. Previous studies have shown that miRNA-372 plays crucial roles gastric tumorigenesis by targeting the mRNA tumor necrosis factor, α-induced protein 1 (TNFAIP1). present study showed miR-373 upregulated adenocarcinoma tissue and carcinoma cell lines when compared to normal tissues. overexpression cancer cells increased proliferation. A bioinformatics search revealed a conserved target site...
Transcription factor AP-2 alpha (AP-2α or TFAP2A) is a newly identified prognostic marker of chemotherapy; its expression positively correlated with chemosensitivity and survival cancer patients.Using computational programs, we predicted that the coding region AP-2α gene contains potential miRNA response element (MRE) miR-193a-5p, single nucleotide polymorphism (SNP) site (c.497A>G, rs111681798) resides within MRE.The results luciferase assays Western blot analysis demonstrated miR-193a-5p...
The gene encoding the tumor suppressor p53 is most frequently mutated in cancers. However, mutation rare acute myeloid leukemia (AML), and inactivated predominantly by aberrant expression of regulators (such as MDM2). A previous study authors revealed that ZCCHC10 protein suppressed MDM2‑mediated degradation lung cancer. role AML have not been investigated. In present study, it was found downregulated bone marrow samples patients significantly negatively correlated with lncRNA SNHG1....
As a member of the polymerase delta-interacting protein 1 (PDIP1) gene family, potassium channel tetramerisation domain-containing 10 (KCTD10) interacts with proliferating cell nuclear antigen (PCNA) and δ, participates in DNA repair, replication cell-cycle control. In order to further investigate physiological functions KCTD10, we generated KCTD10 knockout mice. The heterozygous KCTD10(+/-) mice were viable fertile, while homozygous KCTD10(-/-) showed delayed growth from E9.0, died at...
ABSTRACT Isoniazid and rifampin are essential components of first-line antituberculosis (anti-TB) therapy. Understanding the relationship between genetic factors pharmacokinetics these drugs could be useful in optimizing treatment outcomes, but this is understudied children. We investigated N-acetyltransferase type 2 ( NAT2 ) genotypes isoniazid pharmacokinetics, as well that solute carrier organic anion transporter family member 1B1 (encoded by SLCO1B1 carboxylesterase CES2 single...
The activation of p53 tumor suppressor is essential for preventing abnormal cell proliferation and carcinogenesis. ZCCHC10 was previously identified as a potential p53-interacting partner in yeast two-hybrid screen, but the interaction cells its subsequent influence on activity cancer development have not been investigated. In this paper, we demonstrate that expression levels are statistically lower lung adenocarcinoma tissues than corresponding adjacent noncancerous tissues, decreased mRNA...
Radiative cooling, achieved by selectively emitting thermal radiation to outer space, holds great promise for addressing global energy challenges and mitigating the effects of climate change. However, most radiative cooling materials face limitations in effectively high-heat environments, their performance deteriorates significantly with prolonged outdoor use. These shortcomings restrict widespread application various settings. To address this, we draw inspiration from unique biostructure...
Transcription factor AP-2 regulates transcription of a number genes involving mammalian development, differentiation and carcinogenesis. Recent studies have shown that interaction partners can modulate the transcriptional activity over downstream targets. In this study, we reported identification GAS41 as an partner AP-2β. We documented both in vivo by co-immunoprecipitation well vitro through glutathione S -transferase (GST) pull-down assays. also showed two proteins are co-localized nuclei...
Dysfunction of p53 is a key cause cancer development, while CCDC106 can reduce stability and associated with lung cancer. However, the roles in other types its upstream regulators have not been investigated. The phosphorylation status was investigated by vitro kinase assay Western blotting using phosphorylation-specific antibodies. Co-immunoprecipitation GST-pulldown were used to detect protein interaction. Cell viability, apoptosis, colony formation, wound-healing invasion assays measured...
Human polymerase delta-interacting protein 1 (PDIP1) is a tumor necrosis factor α and interleukin 6 inducible that interacts directly with proliferating cell nuclear antigen (PCNA) the small subunit (p50) of DNA δ. PDIP1 binds PCNA p50 simultaneously stimulates δ activity in vitro presence, but not absence, PCNA. It has been suggested provides link between cytokine activation replication eukaryotes. Here these authors report cloning two rat genes homologous to human PDIP1, termed...
We identified potassium channel tetramerization domain-containing 1 (KCTD1) gene in a human brain cDNA library. Here, we report that the KCTD1 contains seven exons, encoding 257 amino acid residues with predicted molecular mass of 29.4 kDa. Sequence alignments showed protein an N-terminal broad-complex, tramtrack, and bric-a-brac (BTB) domain. Northern blot analysis revealed is expressed mammary gland, kidney, brain, ovary compared to other tissues. Further, subcellular localization results...
// Xing Zhang 1, * , Yichong Ning Yuzhong Xiao 2, Huaxin Duan 3 Guifang Qu Xin Liu 1 Yan Du Dejian Jiang 4 and Jianlin Zhou Key Laboratory of Protein Chemistry Developmental Biology The Ministry Education, College Life Science, Hunan Normal University, Changsha 410081, Hunan, China 2 Biology, 410082, First Affiliated Hospital, 410005, Pharmacodynamics Safety Evaluation New Drugs, 410331, These authors contributed equally to this work Correspondence to: Zhou, email: jlzhou@hunnu.edu.cn...