A5062604514- Bone health and osteoporosis research
- Bone Metabolism and Diseases
- Bone health and treatments
- Hip and Femur Fractures
- Parathyroid Disorders and Treatments
- Bone and Joint Diseases
- Vitamin D Research Studies
- Nutrition and Health in Aging
- Magnesium in Health and Disease
- Growth Hormone and Insulin-like Growth Factors
- Genetic Associations and Epidemiology
- Health Systems, Economic Evaluations, Quality of Life
- Nutritional Studies and Diet
- Hip disorders and treatments
- Chronic Disease Management Strategies
- Liver Disease Diagnosis and Treatment
- Pelvic and Acetabular Injuries
- Gout, Hyperuricemia, Uric Acid
- Bone and Dental Protein Studies
- Histone Deacetylase Inhibitors Research
- Estrogen and related hormone effects
- Blood Pressure and Hypertension Studies
- Pituitary Gland Disorders and Treatments
- Cancer, Lipids, and Metabolism
- Cancer Risks and Factors
Second Xiangya Hospital of Central South University
2016-2025
Central South University
2016-2025
Jiangsu Hengrui Medicine (China)
2021-2025
Shenzhen Pingle Orthopedic Hospital
2025
Hubei University
2024
Southeast University
2024
Xiangya Hospital Central South University
2016-2021
Hunan Normal University
2010-2021
National Clinical Research
2021
Chinese Academy of Medical Sciences & Peking Union Medical College
2021
MicroRNAs (miRNAs) interfere with translation of specific target mRNAs and are thought to thereby regulate many cellular processes. Recent studies have suggested that miRNAs might play a role in osteoblast differentiation bone formation. Here, we identify new miRNA (miR-2861) primary mouse osteoblasts promotes by repressing histone deacetylase 5 (HDAC5) expression at the post-transcriptional level. miR-2861 was found be transcribed ST2 stromal cells during morphogenetic protein 2-induced...
Population structure and lifestyles may have contributed to the epidemiological status of Chronic Kidney Disease due Type 2 Diabetes (CKD-T2D). This study is a secondary data analysis. Using from Global Burden Study, we describe changes in CKD-T2D burden its influencing factors population aged 20-59 years 1990 2019. Globally, incidence, death, Disability Adjusted Life Years (DALYs) rate showed an upward trend increased with age, males was higher than that females. growth aging were important...
Summary Objectives To investigate the relationship between serum sclerostin level, body composition, and bone mineral density (BMD) in central south Chinese postmenopausal women. Methods A cross‐sectional study was conducted on 260 healthy southern women with vs without osteoporosis, aged 50–76 years old. Dual X‐ray absorptiometry used to measure content BMD of whole body, lumbar spine left femur, total soft tissue composition. Serum levels were measured by a quantitative sandwich...
Omentin-1 (also known as intelectin-1) is a recently identified visceral adipose tissue-derived cytokine that inversely related to obesity. Our previous study showed omentin-1 inhibits osteoblastic differentiation of calcifying vascular smooth muscle cells (CVSMCs) in vitro. This was undertaken investigate the effects on arterial calcification and bone metabolism vivo. In vitro, stimulated production osteoprotegerin (OPG) inhibited receptor activator for nuclear factor κB ligand (RANKL) both...
Recent studies suggest that serum lipid profiles are related to bone mineral density (BMD). But data about this relationship on Chinese population scarce. We investigated the relationships between and BMD in postmenopausal women.A cross-sectional study was conducted 790 women. BMDs were measured by dual X-ray absorptiometry. Serum obtained after a 12-h fasting.Women with high-density lipoprotein cholesterol (HDL-C) levels of at least 1·55 mmol/l had greater prevalence osteoporosis compared...
The ‘diabetic bone paradox’ suggested that type 2 diabetes (T2D) patients would have higher areal mineral density (BMD) but fracture risk than individuals without T2D. In this study, we found the genetically predicted T2D was associated with BMD and lower of in both weighted genetic score (wGRS) two-sample Mendelian randomization (MR) analyses. We also identified ten genomic loci shared between fracture, top signal at SNP rs4580892 intron gene RSPO3 . And expression adipose subcutaneous...
(1) Background: This study aimed to investigate the relationship of triglyceride glucose−body mass index (TyG-BMI) with bone mineral density (BMD), femoral neck geometry, and risk fracture in middle-aged elderly Chinese individuals. (2) Methods: A total 832 nondiabetic individuals were selected from prospective population-based HOPE cohort. All underwent DXA for assessment BMD at lumbar spine, neck, hip, as well geometry. The 10-year probabilities both major osteoporotic (MOFs) hip fractures...
Handgrip strength (HGS) and the appendicular lean mass index (ALMI) are important determinants of sarcopenia. Muscle quality (MQ) is a measure muscle relative to mass. We examined trends in handgrip strength, index, analyzed their relationship with age, anthropometry, body composition sample participants United States (US).
Abstract Rice blast, caused by Magnaporthe oryzae ( M. ), is one of the most common and damaging diseases rice that limits yield quality. The mediator complex plays a vital role in promoting transcription bridging specific factors RNA polymerase II. Here, we show subunit OsMED16 essential for full induction diterpenoid phytoalexin biosynthesis genes resistance to ascomycetous fungus . Mutants Osmed16 reduced expression DP are markedly more susceptible , while transgenic plants overexpressing...
<b><i>Aims:</i></b> This study was designed to assess vitamin D (25(OH)D) status and its relationship with bone mineral density (BMD) fracture risk, which determined using the FRAX algorithm, among postmenopausal central south Chinese women, identify risk factors for deficiency osteoporosis. <b><i>Methods:</i></b> cross-sectional involved 578 healthy women. Fat mass BMD at lumbar spine (L1-L4), femur neck total hip were measured dual X-ray...
Muscle fat infiltration and atrophy were common pathomorphologic changes in the paravertebral muscles. Some studies indicated that degeneration of muscles may be one important causes chronic neck pain. Therefore, we investigated mechanical effects multifidus muscle morphologic on cervical spine tissues by constructing models multfiidus with different degrees atrophy. Three-dimensional finite element 100%, 80%, 50% constructed referring to previous literature. According loading conditions...
Somatotroph-pituitary neuroendocrine tumors (PitNETs) represent one of the most prevalent functional pituitary adenoma subtypes. Achieving biochemical remission has been established as primary determinant for improving quality life in affected patients. Nevertheless, current clinical outcomes demonstrate suboptimal rates cases invasive somatotroph-PitNETs, predominantly attributable to cavernous sinus invasion and postoperative residual lesions. Our retrospective cohort study reveals that...
Type 1 diabetes mellitus related chronic kidney disease (T1DM-CKD) presents a global health challenge, with unclear trends and patterns among adolescents young adults. This study analyzed the burden risk factors of T1DM-CKD in individuals aged 15 to 39 from 1990 2021 predicted future trends. Using data Global Burden Disease (GBD) 2021, we prevalence, incidence, mortality, disability-adjusted life years (DALYs), average annual percentage change (AAPC) youth across gender, sociodemographic...
Abstract Recently, a membrane-based estrogen receptor (ER), ER-α36, was identified and cloned that transduces membrane-initiated signaling such as activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) pathway. Here we show postmenopausal level estradiol (E2) induces mitogenic, antiapoptotic, antiosteogenic effects proapoptotic in osteoblasts osteoclasts with high levels ER-α36 expression, respectively. We also found mediated postmenopausal-level...
To elucidate the relationship between body composition and bone mineral density (BMD) prevalence of osteoporosis in central south Chinese postmenopausal women.A cross-sectional study was conducted on 954 healthy southern women, aged 50-82. Total body, lumbar spine left femur BMD total soft tissue were measured by dual X-ray absorptiometry.Among population, 578 (60.5%) subjects without 376 (39.4%) osteoporotic. The osteoporotic women older, shorter thinner, had an earlier age at menopause, a...