A5064864346- Nutrition and Health in Aging
- Frailty in Older Adults
- Physical Activity and Health
- Health disparities and outcomes
- Dementia and Cognitive Impairment Research
- Obesity, Physical Activity, Diet
- Adolescent Sexual and Reproductive Health
- Global Maternal and Child Health
- Nutritional Studies and Diet
- Health and Wellbeing Research
- Blood Pressure and Hypertension Studies
- Cardiovascular Health and Risk Factors
- Family and Disability Support Research
- Supercapacitor Materials and Fabrication
- Poverty, Education, and Child Welfare
- Child and Adolescent Psychosocial and Emotional Development
- Advancements in Battery Materials
- Health Systems, Economic Evaluations, Quality of Life
- Food Security and Health in Diverse Populations
- Family Caregiving in Mental Illness
- Folate and B Vitamins Research
- Diet and metabolism studies
- Cardiac Health and Mental Health
- Cardiovascular Health and Disease Prevention
- Stroke Rehabilitation and Recovery
Hiroshima University
2021-2025
Nanjing Drum Tower Hospital
2025
Kyushu University
2008-2023
Karnavati University
2023
Kyushu Dental University
2023
National Defence University of Malaysia
2023
Sant Gadge Baba Amravati University
2023
National Institute of Cardiovascular Diseases
2023
Imperial College London
2022
National Institute of Advanced Industrial Science and Technology
2022
Abstract Background Subjective cognitive decline (SCD) is recognized as a risk stage for Alzheimer’s disease (AD) and other dementias, but its prevalence not well known. We aimed to use uniform criteria better estimate SCD across international cohorts. Methods combined individual participant data 16 cohorts from 15 countries (members of the COSMIC consortium) used qualitative quantitative (Item Response Theory/IRT) harmonization techniques prevalence. Results The sample comprised 39,387...
A facile process is developed to prepare SnO2-based composites through using metal–organic frameworks (MOFs) as precursors. The nitrogen-doped graphene wrapped okra-like SnO2 (SnO2@N-RGO) are successfully synthesized for the first time by Sn-based (Sn-MOF) When utilized an anode material lithium-ion batteries, SnO2@N-RGO possess a remarkably superior reversible capacity of 1041 mA h g–1 at constant current 200 after 180 charge–discharge processes and excellent rate capability. performance...
This study aimed to examine the associations between time spent in prolonged and non-prolonged sedentary bouts development of metabolic syndrome.We used data from a prospective Japanese workers. Baseline examination was conducted 2010 2011. A total 430 office workers (58 women) aged 40-64 years without syndrome were followed up by annual health checkups until 2014. Metabolic defined as having ≥ 3 out 5 diagnostic criteria Joint Interim Statement 2009 definition. Sedentary assessed using...
Abstract Amino acids have emerged as novel biomarkers for predicting type 2 diabetes (T2D), but the epidemiologic data linking circulating amino acid profiles with T2D are sparse in Asian populations. We conducted a nested case-control study within cohort of 4,754 nondiabetic Japanese employees who attended comprehensive health checkup 2008–2009 and agreed to provide blood samples. During 5-year follow-up, incident cases were ascertained based on plasma glucose, glycated hemoglobin,...
Idiopathic pulmonary fibrosis (IPF) is a fibrotic disease driven by both environmental and genetic factors. Epigenetics refers to changes in gene expression or cellular phenotype that do not involve alterations DNA sequence. KMT2A member of the SET family which catalyses H3K4 methylation. Through microarray single-cell sequencing data, we discovered KMT2A-positive fibroblasts were increased IPF lung tissues. level was bleomycin-induced mice tissues collected our centre. Mice with...
Malignant glioma is a common and severe primary brain tumor with high recurrence rate an extremely mortality within 2 years of diagnosis, even when surgical, radiological, chemotherapeutic interventions are applied. Intravenously administered drugs have limited use because their adverse systemic effects poor blood–brain barrier penetration. Here, we combine methods to increase drug delivery tumors. Focused ultrasound transiently permeabilizes the barrier, increasing passive diffusion....
Omentin-1 (also known as intelectin-1) is a recently identified visceral adipose tissue-derived cytokine that inversely related to obesity. Our previous study showed omentin-1 inhibits osteoblastic differentiation of calcifying vascular smooth muscle cells (CVSMCs) in vitro. This was undertaken investigate the effects on arterial calcification and bone metabolism vivo. In vitro, stimulated production osteoprotegerin (OPG) inhibited receptor activator for nuclear factor κB ligand (RANKL) both...
The low physical activity domain of the frailty phenotype has been assessed with various self-reported questionnaires, which are prone to possible recall bias and a lack diagnostic accuracy. primary purpose this study was define using accelerometer-based measurement evaluate internal construct validity among older community-dwellers. Secondly, we examined potential correlates in population. We conducted cross-sectional 1,527 community-dwelling men women aged 65 over. Data were drawn from...
Abstract Background Several prospective Western studies have reported an inverse association of vegetable and fruit intake with dementia risk. However, there is limited epidemiologic evidence in Asians. This study investigated the intakes vegetables, fruits, their nutrients on risk incident its subtypes a Japanese community. Methods A total 1071 participants (452 men 619 women) aged ≥60 years without at baseline were prospectively followed up for 24 years. Intakes evaluated using 70-item...
Sedentary behavior has been reported to be associated with metabolic and vascular health independent of moderate-to-vigorous physical activity (MVPA). In order select appropriate options measure sedentary in practice research settings, it is worthwhile characterize the extent which objective subjective measures quantify adverse risks same population. This cross-sectional analysis compared accelerometer-derived self-reported time identify their association cardio-metabolic risk factors....
Aim . The aim of this study was to identify the impact bedtime, wake time, sleep duration, sleep-onset latency, and quality on depressive symptoms suicidal ideation amongst Japanese freshmen. Methods This cross-sectional data derived from baseline survey Enhancement Q-University Students Intelligence (EQUSITE) conducted May June, 2010. A total 2,631 participants were recruited completed following self-reported questionnaires: Pittsburgh Sleep Quality Index (PSQI), Center for Epidemiologic...
To assess the relationship between physical frailty and subsequent decline in global cognitive function non-demented elderly.
Aim:To develop and validate a new risk prediction model for predicting the 10-year of atherosclerotic cardiovascular disease (ASCVD) in Japanese adults.
Epidemiological studies suggest that the severity of periodontitis is higher in people with diabetes than healthy individuals. Insulin resistance might play a crucial role pathogenesis multiple diabetic complications and reportedly induced gingiva rodents type 2 diabetes; however, molecular mechanisms underlying diabetes-related remain unclear. Therefore, we aimed to investigate whether endothelial insulin may contribute as well elucidate its mechanisms. We demonstrated treatment...
Summary The ultrastructure of Ehrlichia chaffeensis (Arkansas strain) was studied in non-irradiated and irradiated monolayers mouse embryo, Vero, BGM L929 cells, DH82 cells. Within the intracellular parasitophorous vacuoles (morulae), two types ehrlichial cells were found regularly—those with uniformly dispersed nucleoid filaments ribosomes (reticulate cells) smaller ones centrally condensed (dense-cored cells), which represent normal life cycle ehrlichiae. In addition, large reticulate...
This cross-sectional study was performed to examine associations of objectively measured sedentary time (ST) and breaks in (BST) with instrumental activities daily living (IADL) disability Japanese community-dwelling older adults.The sample comprised 1634 adults (mean age: 73.3 y, men: 38.4%). Sedentary behavior using a triaxial accelerometer. Disability defined as inability at least 1 the IADL tasks Tokyo Metropolitan Institute Gerontology Index Competence.After adjusting for potential...
To investigate the associations of global cognitive performance with frailty and pre-frailty in non-demented community-dwelling older adults.A cross-sectional study was carried out using data from baseline survey Sasaguri Genkimon Study 2011. The sample consisted 1565 adults complete no evidence dementia. Global evaluated Montreal Cognitive Assessment (MoCA) Mini-Mental State Examination (MMSE). Frailty state defined Cardiovascular Health criteria, based on five components: unintentional...
This study aims to explore the multilevel mediation effects of cognitive emotion regulation strategies (CERS) on link between neuroticism and depressive symptoms among Chinese adolescents.A total 1,265 adolescents were surveyed using version Cognitive Emotion Regulation Questionnaire (CERQ-C), scale children's Eysenck Personality (EPQ-Ck), Children's Depressive Inventory (CDI-C). Partial correlation analyses, multigroup confirmatory factor structural equation modeling used.(1) Neuroticism...
Abstract Background It is unknown whether moderate-to-vigorous physical activity (MVPA) in bouts of <10 minutes protects against disability risks or if only 10 MVPA critical. Additionally, it unclear light (LPA) its accumulation patterns associated with functional disability. Methods A total 1,687 adults aged ≥65 years and without at baseline were followed up for 6 years. Functional was identified using the database Japan’s Long-term Care Insurance System. Physical measured a...
Abstract Background Evidence is scarce on the trend in prevalence of physical frailty China; primary purpose this study was to identify and correlates among older nursing home residents China. Methods Cross-sectional 20 homes Changsha, Physical defined based phenotype including weight loss, low grip strength, exhaustion, slow gait speed, activity. Participants with at least three affected criteria were as being frail. one or two considered pre-frail, those no robust. A total 1004 aged 60...
Abstract Objective: Improved food availability and a growing economy in Tanzania may insufficiently decrease pre-existing nutritional deficiencies simultaneously increase overweight within the same individual, household or population, causing double burden of malnutrition (DBM). We investigated economic inequalities DBM at level, expressed as stunted child with mother overweight/obesity, moderating role dietary diversity these inequalities. Design: used cross-sectional data from 2015–2016...
To examine the associations of accelerometer-measured physical activity and sedentary time with all-cause mortality in older Japanese adults. A total 1723 independent adults aged ≥65 years were followed from 2011 to 2021. Moderate-to-vigorous (MVPA), light (LPA) measured using a triaxial accelerometer secured participants' waists. Over median follow-up 9.9 years, 336 deaths recorded. When examined as tertiles, higher MVPA (both ≥10 <10 min bouts) LPA associated lower risk. Additional...