A5055937178- Health disparities and outcomes
- Frailty in Older Adults
- Dementia and Cognitive Impairment Research
- Nutrition and Health in Aging
- Nutritional Studies and Diet
- Health Systems, Economic Evaluations, Quality of Life
- Aging and Gerontology Research
- Tea Polyphenols and Effects
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Retirement, Disability, and Employment
- Obesity, Physical Activity, Diet
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Tryptophan and brain disorders
- Folate and B Vitamins Research
- Neurological Disease Mechanisms and Treatments
- Birth, Development, and Health
- Child Nutrition and Water Access
- Diabetes Management and Research
- Psychological Well-being and Life Satisfaction
- Global Health Care Issues
- Health, Environment, Cognitive Aging
- Health and Well-being Studies
- Curcumin's Biomedical Applications
- Health, psychology, and well-being
- Balance, Gait, and Falls Prevention
National University of Singapore
2013-2024
Witten/Herdecke University
2023
University of Bologna
2023
Radboud University Nijmegen
2023
Radboud University Medical Center
2023
Radboud Institute for Molecular Life Sciences
2023
The University of Sydney
2023
University of Hull
2023
Alzheimer’s Disease Neuroimaging Initiative
2023
Union Bank of Switzerland
2023
We aimed to examine the relationship between tea consumption and cognitive function in older adults. Cross-sectional study. The Singapore Longitudinal Aging Studies (SLAS), a community-based study urban Singapore. 716 Chinese adults aged ≥ 55 years. Self-reported current habits (frequency type). Cognitive performance was assessed by battery of neuropsychological tests; composite domain scores on attention, memory, executive function, information processing speed were computed using raw test...
Abstract Background Subjective cognitive decline (SCD) is recognized as a risk stage for Alzheimer’s disease (AD) and other dementias, but its prevalence not well known. We aimed to use uniform criteria better estimate SCD across international cohorts. Methods combined individual participant data 16 cohorts from 15 countries (members of the COSMIC consortium) used qualitative quantitative (Item Response Theory/IRT) harmonization techniques prevalence. Results The sample comprised 39,387...
Background Prospective cohort studies suggest that frailty is associated with an increased risk of incident cardiovascular disease (CVD) morbidity and mortality, but their mechanistic developmental relations are not fully understood. We investigated whether predicted nonfatal fatal CVD among community-dwelling older adults. Methods A population 5015 participants aged 55 years above free at baseline was followed for up to 10 years. Pre-frailty were defined as the presence 1–2 3–5 modified...
Objective: The association between exposure to stressful life events (SLEs) and late-life depression is well-documented. However, the role of resilience as a buffer against adverse mental health effects SLEs in late has not been convincingly demonstrated. In this paper, moderating effect relationship depressive symptomatology older Chinese adults investigated.
To investigate whether life event stress was associated with greater psychological distress and poorer quality of in older individuals chronic obstructive pulmonary disease (COPD), comparison their counterparts without COPD.
<b><i>Background:</i></b> Studies report varying rates and predictors of mild cognitive impairment (MCI) progression reversion. <b><i>Methods:</i></b> We determined MCI reversion among 473 community-living adults aged ≥55 years in the Singapore Longitudinal Ageing Study with an average 6 follow-up estimated association baseline variables. <b><i>Results:</i></b> A total 208 participants reverted to normal cognition...
Abstract Introduction Though consistent evidence suggests that physical activity may delay dementia onset, the duration and amount of required remains unclear. Methods We harmonized longitudinal data 11,988 participants from 10 cohorts in eight countries to examine dose‐response relationship between late‐life incident among older adults. Results Using no as a reference, risk decreased with up 3.1 6.0 hours/week (hazard ratio [HR] 0.88, 95% confidence interval [CI] 0.67 1.15 for 0.1 3.0...
Cognitive frailty is associated with higher risk of dementia and adverse health outcomes. However, multidimensional factors that influence cognitive transitions are not known. We aimed to investigate incident frailty.Prospective cohort study participants were community-dwelling adults without other degenerative disorders baseline follow-up, including N = 1,054 aged ≥55 free at baseline, complete (March 6, 2009, June 11, 2013) follow-up data 3-5 years later (January 16, 2013, August 24,...
To investigate risk factors of incident physical frailty. A population-based observational longitudinal study. Community-dwelling elderly with age 55 years and above recruited from 2009 through 2011 in the second wave Singapore Longitudinal Ageing Study-2 (SLAS-2) were followed up 3–5 later. total 1297 participants, mean 65.6 ±0.19, who free Incident frailty defined by three or more criteria phenotype used Cardiovascular Health Study was determined at follow-up. Potential assessed baseline...
Experimental evidence suggest that tea polyphenols have anti-depressant effect and consumption may reduce the risk severity of depression. We investigated whether was associated with changes in depressive symptoms over time among Asian older adults. Population-based prospective cohort study mean 4 years follow up. Singapore Longitudinal Ageing Study (SLAS) community-living persons. 3177 participants overall (mean age 67 years) 3004 who were depression-free at baseline. Baseline which include...
Higher levels of happiness are associated with longer life expectancy. Our study assessed the extent to which various factors explain protective effect on all-cause mortality risk, and whether association differs between older men women.Using data from Singapore Longitudinal Aging Studies (N = 6073) community-dwelling adults aged ≥ 55 years, we analyzed baseline Likert score (1 very sad 5 happy) mean 11.7 years follow up. Cox regression models were used assess confounding risk attenuated...
To characterize the physical frailty phenotype and its associated functional impairments in mild cognitive impairment (MCI).Participants with MCI (N = 119), normal low cognition (NLC, N 138), high (NHC, 1,681) Singapore Longitudinal Ageing Studies (SLAS-2) were compared on prevalence of frailty, lean body mass, weakness, slow gait, exhaustion activity, POMA balance gait fall risk.There significantly higher (18.5%), than NLC (8.0%) NHC (3.9%), pre-frailty (54.6%), (52.9%) (48.0%). Age, sex,...
Motor and gait disturbances are evident in early Alzheimer non-Alzheimer dementias may predict the likelihood of mild cognitive impairment (MCI) or progression to dementia.We investigated Timed-Up-and-Go (TUG) measure functional mobility predicting decline incident MCI dementia (MCI-dementia).Prospective cohort study with 4.5 years follow-up.Population based.2,544 community-dwelling older adults aged 55+ years.Participants baseline data on TUG, fast speed (GS), knee extension strength (KES)...
<b><i>Introduction:</i></b> The identification of modifiable health span-promoting factors is a public priority. <b><i>Objective:</i></b> To explore the socio-environmental, lifestyle, behavioural, and psychological determinants clinical phenotypic measure biological ageing in Singapore Longitudinal Ageing Study (SLAS) cohort. <b><i>Methods:</i></b> Using cross-sectional data on 2,844 SLAS-2 adults with chronological age...
ad hoc approaches are used to create composite indexes of intrinsic capacity (IC) based on five domains recommended by the World Health Organization for healthy ageing. We examined how combinations domain-specific measures determine measurement performances IC indexes.in this population-based prospective cohort study, community-dwelling older persons (N = 2,906) aged 55 years and above were recruited. 12 measures: cognition (Mini-Mental State Examination, MMSE), psychological (Geriatric...
The potential neurocognition protective effects of dietary curcumin in curry consumed with food was investigated this study 2734 community-dwelling adults (aged ≥ 55, mean ± SD: 65.9 7.4). We analyzed longitudinal data baseline consumption (“never or rarely”, “occasionally”: <once a month, “often”: >once month and week, “very often”: week daily) 4.5-year follow-up cognitive function mixed model analyses controlling for confounding risk factors. Significant between-exposure differences were...
Abstract Background real-world observations on the long-term benefits of Tai Chi (TC) exercise, in terms physical and cognitive functioning, frailty, quality life (QOL) mortality are lacking. Methods prospective cohort study participants were community-dwelling adults aged 55+, including 5,407 non-frequent TC (&lt;1x/week) 572 frequent (≥1x/week). Outcome measures at baseline 3–5 years follow-up included performance (Knee Extension Strength, POMA Balance Gait, Timed-up-and-go, Gait...