A5100410294- Psoriasis: Treatment and Pathogenesis
- RNA modifications and cancer
- Gut microbiota and health
- Asthma and respiratory diseases
- Climate Change and Health Impacts
- Air Quality and Health Impacts
- Vitamin D Research Studies
- Ubiquitin and proteasome pathways
- Synthesis of β-Lactam Compounds
- Pulmonary Hypertension Research and Treatments
- Synthesis and Biological Evaluation
- Energy and Environment Impacts
- Cancer-related gene regulation
- Atherosclerosis and Cardiovascular Diseases
- Bone health and osteoporosis research
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Dermatology and Skin Diseases
- Extracellular vesicles in disease
- Complement system in diseases
- IL-33, ST2, and ILC Pathways
- Glycosylation and Glycoproteins Research
- Spondyloarthritis Studies and Treatments
- Hip and Femur Fractures
- Neonatal Respiratory Health Research
Chengdu Women's and Children's Central Hospital
2024-2025
Central South University
2012-2025
University of Electronic Science and Technology of China
2024-2025
Xiangya Hospital Central South University
2016-2024
Hunan Cancer Hospital
2020-2024
Second Xiangya Hospital of Central South University
2004-2024
Beihang University
2021-2024
Zhuzhou Central Hospital
2019-2023
Huazhong Agricultural University
2023
National Health and Family Planning Commission
2023
Tumor cells increase glutamate release through the cystine/glutamate transporter cystine-glutamate exchange (xCT) to balance oxidative homeostasis in tumor and promote progression. Although clinical studies have shown potential of targeting programmed cell death 1 (PD-1)/programmed ligand (PD-L1) signaling melanoma, response rates are low. However, it remains unclear how metabolism affects anti-PD-1/PD-L1 treatment efficacy melanoma. Here, we demonstrated that although inhibition xCT either...
(1) Background: This study aimed to investigate the relationship of triglyceride glucose−body mass index (TyG-BMI) with bone mineral density (BMD), femoral neck geometry, and risk fracture in middle-aged elderly Chinese individuals. (2) Methods: A total 832 nondiabetic individuals were selected from prospective population-based HOPE cohort. All underwent DXA for assessment BMD at lumbar spine, neck, hip, as well geometry. The 10-year probabilities both major osteoporotic (MOFs) hip fractures...
Diabetic nephropathy (DN) causes serious renal tubule and interstitial damage, but effective prevention treatment measures are lacking. Abnormal mitophagy may be involved in the progression of DN, its upstream downstream regulatory mechanisms remain unclear. Melatonin, a pineal hormone associated with circadian rhythms, is regulating mitochondrial homeostasis. Here, we demonstrated abnormal kidneys DN mice or high glucose (HG)-treated HK-2 cells, which was accompanied by increased oxidative...
Psoriasis is a chronic inflammatory disease of the skin. A few studies have shown that psoriasis an immune-mediated in which multiple immune cells play crucial roles. However, association between circulating and remains elusive.To explore role psoriasis, 361,322 individuals from UK Biobank (UKB) 3,971 patients with China were included to investigate white blood via observational study. Genome-wide (GWAS) Mendelian randomization (MR) used evaluate causal relationship leukocytes psoriasis.The...
Elderly-onset atopic dermatitis (AD) is a remarkable subtype and has been put on the agenda owing to its difficulty control. Understanding influence of genetic environmental exposures crucial preventing elderly-onset AD.To explore association between genes air pollution incident AD.This study was based UK Biobank that recruited over 500,000 participants. The risks were categorized into low, intermediate, high groups according tertiles polygenic risk scores. Mixed exposure various pollutants...
Numerous studies have explored the association of air pollution with asthma but yielded conflicting results. The exact role in incidence adult-onset and whether this effect is modified by genetic risk, lifestyle, or their interaction remain uncertain.We conducted a prospective cohort study on 298,738 participants (aged 37-73 years) registered UK Biobank. Cox proportional hazard models were used to evaluate pollution, including particulate matter (PM2.5, PMcoarse, PM10), nitrogen dioxide...
Handgrip strength (HGS) and the appendicular lean mass index (ALMI) are important determinants of sarcopenia. Muscle quality (MQ) is a measure muscle relative to mass. We examined trends in handgrip strength, index, analyzed their relationship with age, anthropometry, body composition sample participants United States (US).
Little is known about the associations between long-term exposure to wildfire-related fine particulate matter (PM2.5) and mortality. We aimed explore theses using data from UK Biobank cohort. Long-term PM2.5 was defined as 3-year cumulative concentrations of within a 10-km buffer surrounding residential address for each individual. Hazard ratios (HRs) with 95% confidence intervals (CIs) were estimated time-varying Cox regression model. included 492,394 participants aged 38 73 years. found...
Objectives: Although healthy lifestyle behaviors are associated with a lower risk of psoriasis, the underlying metabolic mechanisms remain unclear.Methods: We analyzed 190,692 participants (aged 38–73) from UK Biobank complete data on and serum metabolites. Healthy was assessed based diet, exercise, smoking, BMI. The association between lifestyle-related metabolites late-onset psoriasis identified by sequential analytic strategy that combined Cox regression elastic net model. A machine...
To investigate the specific characteristics and differences in placental microbiome of preterm infants with without pneumonia. Fifty-nine born at 32-36 weeks' gestation were enrolled this study. Among them, 33 developed pneumonia within 48 hours birth, while remaining 26 did not. Placental swabs collected birth for DNA extraction, from which microbial composition was analyzed using a bioinformatics pipeline following PCR amplification genetic material subsequent sequencing bacterial 16S...
Background Vitamin D has been known to be associated with asthma. However, the association between vitamin status and asthma, lung function as well hospitalization among adults remains unclear. Objective To investigate role of serum in asthma prevalence, function, control adults. Methods Multivariable logistic regression was applied assess relationship (FEV1, FVC, FEV1/FVC), current wheeze, asthma-linked hospitalizations a cross-sectional study 435,040 aged 37–73 years old from UK Biobank....
Both atopic diseases and dysregulation of serum lipids (SLs) add to significant health burden, but evidences about their association are inconsistent.This work is evaluate the between asthma/atopic dermatitis (AD) SLs investigate potential causal relationship.A large-scale cross-sectional study based on UK Biobank (UKB) then examined casual relationships with asthma/AD a Mendelian randomization (MR) analysis.A total 502,505 participants were included in analysis. After full adjustment, AD...
Dermatofibrosarcoma protuberans (DFSP) is a rare and marginal cutaneous sarcoma of intermediate-grade malignancy, for which the genomic landscape remains unclear. Understanding DFSP will help to further classify pathway malignant development in soft tissue.To identify comprehensive molecular pathogenesis DFSP.In this study, features, with 53 tumour-normal pairs DFSP, were revealed by whole-genome sequencing.The mutational signature 1 (C > T mutation at CpG dinucleotides) featured resulting...
Background Plenty of observational studies suggested that vitamin D concentrations were associated with psoriasis, but the causality this relationship was elusive. Objective To investigate causal between and psoriasis. Methods Cox proportional hazard model used to association status psoriasis in a prospective cohort study from UK Biobank. Single nucleotide polymorphisms (SNPs) are strongly circulating 25OHD constructed as instrumental variables Mendelian randomization (MR) determine Results...
The homeostasis of the microbiota is essential for human health. In particular, gut plays a critical role in regulation immune system. Thus, faecal transplantation (FMT), technology that has rapidly developed last decade, specifically been utilised treatment intestinal inflammation and recently found to be able treat tumours combination with immunotherapy. FMT become breakthrough enhancing response rate immunotherapy cancer patients by altering composition patient's microbiota. This review...