A5102940766- Radiomics and Machine Learning in Medical Imaging
- MRI in cancer diagnosis
- Hepatocellular Carcinoma Treatment and Prognosis
- Arsenic contamination and mitigation
- Heavy Metal Exposure and Toxicity
- Advanced MRI Techniques and Applications
- Electrochemical Analysis and Applications
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Health and Wellbeing Research
- Oral health in cancer treatment
- Lung Cancer Research Studies
- Berberine and alkaloids research
- Hereditary Neurological Disorders
- Vasculitis and related conditions
- Amoebic Infections and Treatments
- Fatty Acid Research and Health
- Renal and related cancers
- Sarcoidosis and Beryllium Toxicity Research
- Advanced Neuroimaging Techniques and Applications
- Clostridium difficile and Clostridium perfringens research
- Cancer, Lipids, and Metabolism
- Mesenchymal stem cell research
- MicroRNA in disease regulation
- School Health and Nursing Education
Xiangya Hospital Central South University
2009-2025
Central South University
2009-2025
Sichuan University
2024
West China Hospital of Sichuan University
2024
Hunan Cancer Hospital
2024
China Agricultural University
2023
National Clinical Research
2021
Charité - Universitätsmedizin Berlin
2021
Second Xiangya Hospital of Central South University
2018-2021
Intratumoral tertiary lymphoid structures (iTLS) in hepatocellular carcinoma (HCC) are associated with improved survival and may influence treatment decisions. However, their non-invasive detection remains challenging HCC. We aim to develop a model using baseline contrast-enhanced MRI predict the iTLS status. A total of 660 patients HCC who underwent surgery were retrospectively recruited from four centers between October 2015 January 2023 divided into training, internal test, external...
The influence of chronic arsenic exposure on cognitive impairment has been explored broadly by previous studies. However, most them focused mainly children rather than adults. In addition, in China, studies this field are not sufficient. To illustrate how long-term affects function, we designed a cross-sectional study involving 1556 adults.All came from three locations around the Realgar Plant. function participants was evaluated using Chinese version Mini-mental state Examination (MMSE)....
Background Multiparametric MRI is used for depiction of prostate cancer (PCa) but without consideration the mechanical alteration prostatic tissue by cancer. Purpose To investigate diagnostic performance stiffness and fluidity quantified with tomoelastography, a multifrequency MR elastography technique, PCa compared multiparametric Prostate Imaging Reporting Data System (PI-RADS) version 2.1. Materials Methods Prospective participants suspected to have healthy controls (HCs) underwent...
The homeostasis of the microbiota is essential for human health. In particular, gut plays a critical role in regulation immune system. Thus, faecal transplantation (FMT), technology that has rapidly developed last decade, specifically been utilised treatment intestinal inflammation and recently found to be able treat tumours combination with immunotherapy. FMT become breakthrough enhancing response rate immunotherapy cancer patients by altering composition patient's microbiota. This review...
Background Diffusion‐weighted imaging (DWI) is a useful technique to detect pancreatic lesion. In DWIs, field‐of‐view optimized and constrained undistorted single‐shot (FOCUS) can improve the spatial resolution multiplexed sensitivity‐encoding (MUSE) gain high signal‐to‐noise ratio (SNR). Based on advantage of FOCUS MUSE, new DWI sequence—named FOCUS‐MUSE (FOCUS combined with MUSE)—was developed delineate pancreas. Purpose To investigate reliability compared FOCUS, MUSE (SS) via systematical...
Few studies have examined the effect of individual counseling for smoking cessation in China. The present study evaluated efficacy patients with chronic obstructive pulmonary disease (COPD) and asymptomatic smokers. This prospective randomized 85 smokers COPD 105 normal lung function. individuals were randomly allocated to intervention control groups. Subjects group provided cognitive based on face-to-face consultation, self-help materials nine telephone follow-ups. simple advice. status all...
This study investigated the effects of total alkaloids in Stephania tetrandra (TAS) and main alkaloid components tetrandrine, fangchinoline cepharanthine on biological function lung cancer cells mechanism underlying synergistic antitumor TAS cisplatin.RNA sequencing analysis was performed TAS-treated H1299 cells. Differentially expressed genes were identified analyzed, regulatory pathway by gene set enrichment analysis. The mRNA protein expression levels differentially determined using...
<title>Abstract</title> <bold>Background</bold> Hepatic echinococcosis (HE) is a life-threatening parasitic disease that requires precise diagnosis and proper treatment, ultrasonography recommended to diagnosis. However, challenges remain with primary medical workers in the differentiation of HE by ultrasound. This study aims develop an intelligent artificial-intelligence-assisted model, based on ultrasound radiomics flow, differentiate different types HE. <bold>Methods</bold> Between 2005...
Tertiary lymphoid structures (TLS) within the tumor microenvironment have been associated with cancer prognosis and therapeutic response. However, immunological pattern of a high peritumoral TLS (pTLS) density its clinical potential in hepatocellular carcinoma (HCC) remain poor. This study aimed to elucidate biological differences related pTLS develop radiomic classifier for predicting HCC, offering new insights diagnosis treatment. Spatial transcriptomics (n=4) RNA sequencing data (n=952)...
As people live longer, the burden of aging-related brain diseases, especially dementia, is increasing. Brain aging increases risk cognitive impairment, which manifests as a progressive loss neuron function caused by impairment synaptic plasticity via disrupting lipid homeostasis. Therefore, supplemental dietary lipids have potential to prevent aging. This review summarizes important roles in from both structure and mechanism perspectives. Epidemiological animal studies provided evidence...
Macrotrabecular hepatocellular carcinoma (MTHCC) has a poor prognosis and is difficult to diagnose preoperatively. The purpose build validate MRI-based models predict the MTHCC subtype.Two hundred eight patients with confirmed HCC were enrolled. Three (model 1: clinicoradiologic model; model 2: fusion radiomics signature; 3: combined 1 2) built based on their clinical data MR images in training validation cohorts. performance of was assessed using area under curve (AUC). utility estimated by...
Previous studies from our group and other investigators have shown that lung involvement is one of the independent predictors for treatment resistance in patients with myeloperoxidase (MPO)-anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (MPO-AAV). However, it unclear which image features can predict therapeutic response MPO-AAV patients, vital decision-making these patients. Our aim was to develop validate a radiomics nomogram Chinese based on low-dose multiple slices...
To differentiate the clinical features and computed tomography imaging in two types of mixed epithelial stromal tumor kidney (MESTK) to establish a treatment plan for MESTK types.Seventeen patients who underwent multidetector (MDCT) before surgery had pathological diagnosis were enrolled. Their information (R.E.N.A.L. nephrometry score (R.E.N.A.L.-NS), radical nephrectomy (RN), partial (PN), etc.) collected. The radiological included renal sinus fat invagination (SFI), maximal diameter (MD),...
Objective: The purpose of this study was to investigate the associations genetic variants in double-strand break (DSB) repair pathway genes with prognosis patients lung cancer treated platinum-based chemotherapy. Methods: Three hundred ninety-nine who received chemotherapy for at least two cycles were included study. A total 35 single nucleotide polymorphisms (SNPs) DSB repair, base excision (BER), and (NER) genotyped, used evaluate overall survival (OS) progression-free (PFS) using Cox...
Background Integrating vessels encapsulating tumor clusters (VETC) and microvascular invasion (MVI) (VM hereafter) is potentially useful in risk stratification of hepatocellular carcinoma (HCC). However, noninvasive assessment methods for VM are lacking. Purpose To investigate the diagnostic performance tomoelastography assessing status HCC. Study Type Retrospective. Population One hundred sixty‐eight patients with surgically confirmed HCC consisting 115 training 53 validation cohorts,...
Abstract Background: Chronic arsenic exposure is a major public health issue worldwide. Previous studies explored the effects of on cognitive impairment, but majority previous focused school children rather than adults. Moreover, few investigated role in impairment process large scale China.Methods: Aimed to evaluate association between long-term and China, we designed cross-sectional analytical study which 1,556 adults from three locations around Realgar Plant (Heshan Village, Wangyangqiao...
The three-dimensional chemical exchange saturation transfer (3D CEST) technique is a novel and promising magnetic resonance sequence; however, its application in nasopharyngeal carcinoma (NPC) lacks sufficient evaluation. This study aimed to assess the feasibility of 3D CEST predicting short-term treatment outcomes for chemoradiotherapy (CRT) NPC patients. Forty patients fourteen healthy volunteers were enrolled underwent pre-treatment imaging diffusion-weighted (DWI). reliability was...