A5100738697- Dermatology and Skin Diseases
- Psoriasis: Treatment and Pathogenesis
- Air Quality and Health Impacts
- Carcinogens and Genotoxicity Assessment
- Asthma and respiratory diseases
- Pregnancy and preeclampsia studies
- Heavy Metal Exposure and Toxicity
- Acne and Rosacea Treatments and Effects
- COVID-19 Clinical Research Studies
- Allergic Rhinitis and Sensitization
- COVID-19 and healthcare impacts
- DNA Repair Mechanisms
- Urticaria and Related Conditions
- Health Systems, Economic Evaluations, Quality of Life
- Gestational Diabetes Research and Management
- Birth, Development, and Health
- Trace Elements in Health
- SARS-CoV-2 and COVID-19 Research
- Skin Protection and Aging
- Indoor Air Quality and Microbial Exposure
- Heavy metals in environment
- Cutaneous Melanoma Detection and Management
- Contact Dermatitis and Allergies
- Long-Term Effects of COVID-19
- Retinoids in leukemia and cellular processes
Central South University
2016-2025
Xiangya Hospital Central South University
2016-2025
National Clinical Research
2023-2025
National Center for Advancing Translational Sciences
2020-2025
National Institutes of Health
2006-2025
Nanjing Medical University
2016-2025
Jiangsu Province Hospital
2022-2025
Tianjin Medical University General Hospital
2025
Meizhou City People's Hospital
2025
First Affiliated Hospital of Henan University
2025
Benzene is known to have toxic effects on the blood and bone marrow, but its impact at levels below U.S. occupational standard of 1 part per million (ppm) remains uncertain. In a study 250 workers exposed benzene, white cell platelet counts were significantly lower than in 140 controls, even for exposure ppm air. Progenitor colony formation declined with increasing benzene was more sensitive number mature cells. Two genetic variants key metabolizing enzymes, myeloperoxidase NAD(P)H:quinone...
It remains an enigma whether gestational hypertension (GH) and pre-eclampsia (PE) are distinct entities or different spectrum of the same disease. We aimed to compare risk factors outcomes between GH PE.A total 7,633 pregnant women recruited 12 20 weeks gestation in Ottawa Kingston Birth Cohort from 2002 2009 were included analysis. Cox proportional hazards model was used identify for PE by treating age at delivery as survival time. Logistic regression outcome. Subgroup analysis performed...
Abstract Chinese guidelines prioritize the use of Azvudine and nirmatrelvir–ritonavir in COVID‐19 patients. Nevertheless, real‐world effectiveness versus is still lacking, despite clinical trials showing their compared with matched controls. To compare treatments practice, we identified 2118 hospitalized patients, a follow‐up up to 38 days. After exclusions propensity score matching, included 281 recipients who did not receive oxygen therapy at admission. The lower crude incidence rate...
As the COVID-19 pandemic continues to spread, number of associated deaths increase, especially among those with pre-existing conditions. Azvudine is recommended as a priority treatment for patients COVID-19, but its efficacy in conditions unknown.
Genome-wide association studies of lung cancer reported in populations European background have identified three regions on chromosomes 5p15.33, 6p21.33, and 15q25 that achieved genome-wide significance with p-values 10−7 or lower. These been performed primarily cigarette smokers, raising the possibility observed associations could be related to tobacco use, carcinogenesis, both. Since most women Asia do not smoke, we conducted a study adenocarcinoma never-smoking females (584 cases, 585...
Abstract There are concerns about the health effects of formaldehyde exposure, including carcinogenicity, in light elevated indoor air levels new homes and occupational exposures experienced by workers care, embalming, manufacturing, other industries. Epidemiologic studies suggest that exposure is associated with an increased risk leukemia. However, biological plausibility these findings has been questioned because limited information available on ability to disrupt hematopoietic function....
Mitochondria are eukaryotic organelles responsible for energy production. Mitochondrial DNA (mtDNA) lack introns and protective histones, have limited repair capacity compensate damage by increasing the number of mtDNA copies. As a consequence, mitochondria more susceptible to reactive oxygen species, an important determinant cancer risk, it is hypothesized that increased copy may be associated with carcinogenesis. We assessed association lung risk in 227 prospectively collected cases...
Psoriasis is an immune-mediated chronic inflammatory skin disease. Although its pathogenesis not fully understood, Th17 cells and the cytokines they produce, such as IL-17, IL-22 IL-23, play critical roles in of psoriasis. Evidence has demonstrated that psoriasis some common features, including immune responses (due to cells) cytokine profiles, with systematic diseases bowel (IBDs) obesity. Recently, studies have gut microbiota plays a crucial role host homoeostasis response, particular...
The overall suicide rate in China has dropped substantially since the 1990s, with patterns changing significantly. This study aims to further explore latest changes rates China. Data on gender-age-specific for rural and urban residents aged 15 years above were retrieved from official records. Joinpoint regression analyses applied analyze time trends of rates. Overall, significantly 2002 2015. However, national have decreased at a slower pace 2006. Joinpoints also observed among males,...
Increasing evidence indicates that exposure to microcystin-LR (MC-LR) can cause kidney damage. However, the association between MC-LR and chronic disease (CKD) risk in humans has not been studied. Therefore, we conducted a population-based case–control study involving 135 CKD cases matched controls central China analyzed effects of alone as well combined with known factor cadmium (Cd). Compared lowest quartile exposure, highest had 6.56-fold (95% confidence interval [CI]: 2.46, 17.51)...
This study aimed to investigate professional quality of life (ProQOL) in nurses who were fighting against COVID-19 Wuhan and its related factors.COVID-19 epidemic is a major threat public health. Frontline have engaged infection prevention control, isolation, containment However, available data on ProQOL these are limited.From 15 21 March 2020, the Chinese version was utilized survey total 102 through an electronic questionnaire. The stepwise regression analysis performed determine which...
Abstract Psoriasis is a common, chronic immune-mediated systemic disease that had no effective and durable treatment. Mesenchymal stem cells (MSCs) have immunomodulatory properties. Therefore, we performed phase 1/2a, single-arm clinical trial to evaluate the safety efficacy of human umbilical cord-derived MSCs (UMSCs) in treatment psoriasis preliminarily explore possible mechanisms. Seventeen patients with were enrolled received UMSC infusions. Adverse events, laboratory parameters, PASI,...
This study aims to investigate the associations between MTNR1B rs724030 A>G variant and prediabetes risk, along with their correlations clinical features, including plasma glucose serum insulin levels during oral tolerance test (OGTT), islet function, resistance, lipid levels. In particular, we investigated whether there are sex dimorphisms in impact of this on function/insulin resistance. We included 3415 glucose-tolerant healthy 1744 individuals based OGTT. Binary logistic regression was...
Benzene is an industrial chemical and component of gasoline that established cause leukemia. To better understand the risk benzene poses, we examined effect exposure on peripheral blood mononuclear cell (PBMC) gene expression in a population shoe-factory workers with well-characterized occupational exposures using microarrays real-time polymerase chain reaction (PCR). PBMC RNA was stabilized field analyzed comprehensive human array, U133A/B Affymetrix GeneChip set. A matched analysis six...
Although the toxicity of benzene has been linked to its metabolism, dose-related production metabolites is not well understood in humans, particularly at low levels exposure. We investigated unmetabolized urine (UBz) and all major urinary [phenol (PH), E , E- muconic acid (MA), hydroquinone (HQ) catechol (CA)] as minor metabolite, S- phenylmercapturic (SPMA), 250 benzene-exposed workers 139 control Tianjin, China. Median exposure were ∼1.2 p.p.m. for exposed (interquartile range: 0.53–3.34...
Telomere length plays an important role in the maintenance of chromosomal stability and tumorigenesis. We hypothesized that telomere peripheral WBC DNA obtained from healthy individuals would be a predictor future risk developing non-Hodgkin lymphoma.Using new assay to measure relative length, monochrome multiplex quantitative PCR, which strongly correlates with measured by Southern blot (Spearman r = 0.91, P < 0.0001) has high precision (coefficient variation 7%), we compared 107 incident...
Abstract We used natural spline (NS) models to investigate nonlinear relationships between levels of benzene metabolites (E,E-muconic acid, S-phenylmercapturic phenol, hydroquinone, and catechol) exposure among 386 exposed control workers in Tianjin, China. After adjusting for background (estimated from the 60 subjects with lowest exposures), expected mean trends all metabolite increased air concentrations 0.03 88.9 ppm. Molar fractions E,E-muconic acid changed continuously increasing...
Abstract Tobacco and indoor air pollution from smoky coal are major causes of lung cancer in rural Xuanwei County, China. Tuberculosis has been suggested to increase risk, but data prior studies limited. We conducted an analysis a retrospective cohort study 42,422 farmers Xuanwei. In 1992, interviewers administered standardized questionnaire that included lifetime medical history, including tuberculosis. Subjects were followed 1976, with deaths ascertained through 1996. used proportional...
Benzene, an established cause of acute myeloid leukemia (AML), may also one or more lymphoid malignancies in humans. Previously, we identified genes and pathways associated with exposure to high (> 10 ppm) levels benzene through transcriptomic analyses blood cells from a small number occupationally exposed workers.