A5075647150- Mitochondrial Function and Pathology
- Chronic Kidney Disease and Diabetes
- Endoplasmic Reticulum Stress and Disease
- Autophagy in Disease and Therapy
- Adipose Tissue and Metabolism
- Heme Oxygenase-1 and Carbon Monoxide
- Adipokines, Inflammation, and Metabolic Diseases
- Biomedical Research and Pathophysiology
- Advanced Glycation End Products research
- Inflammasome and immune disorders
- Genetic and Kidney Cyst Diseases
- Renal Diseases and Glomerulopathies
- Cancer, Hypoxia, and Metabolism
- Liver Disease Diagnosis and Treatment
- Diabetes Treatment and Management
- Acute Kidney Injury Research
- Tuberculosis Research and Epidemiology
- Pancreatic function and diabetes
- Cholesterol and Lipid Metabolism
- Cardiovascular Disease and Adiposity
- Drug-Induced Hepatotoxicity and Protection
- Metabolism, Diabetes, and Cancer
- interferon and immune responses
- Diet, Metabolism, and Disease
- Lipid metabolism and biosynthesis
Longhua Hospital Shanghai University of Traditional Chinese Medicine
2020-2024
Shanghai University of Traditional Chinese Medicine
2020-2024
Second Xiangya Hospital of Central South University
2018-2024
Xi'an Jiaotong University
2015-2024
Central South University
2018-2024
Zhuzhou Central Hospital
2019-2023
Soil and Fertilizer Institute of Hunan Province
2021-2023
Xiangya Hospital Central South University
2019-2022
Sun Yat-sen University
2022
Hebei Agricultural University
2022
NLRP3/IL-1β activation via thioredoxin (TRX)/thioredoxin-interacting protein (TXNIP) following mitochondria ROS (mtROS) overproduction plays a key role in inflammation. However, the involvement of this process tubular damage kidneys patients with diabetic nephropathy (DN) is unclear. Here, we demonstrated that mtROS accompanied by decreases TRX expression and TXNIP up-regulation. In addition, discovered also associated increases TGF-β DN db/db mice. We reversed these changes mice...
Overexpression of myo-inositol oxygenase (MIOX), a proximal tubular enzyme, exacerbates cellular redox injury in acute kidney (AKI). Ferroptosis, newly coined term associated with lipid hydroperoxidation, plays critical role the pathogenesis AKI. Whether or not MIOX damage by accelerating ferroptosis cisplatin-induced AKI remains elusive. Cisplatin-treated HK-2 cells exhibited notable cell death, which was reduced inhibitors. Also, alterations various metabolic sensors, including glutathione...
Abstract Background Oligodendrocytes (OLs) death after spinal cord injury (SCI) contributes to demyelination, even leading a permanent neurological deficit. Besides apoptosis, our previous study demonstrated that OLs underwent receptor-interacting serine-threonine kinase 3(RIP3)/mixed lineage domain-like protein (MLKL)-mediated necroptosis. Considering necroptosis is always accompanied with pro-inflammatory response and quercetin has long been used as anti-inflammatory agent, in the present...
Abstract Renal tubulointerstitial fibrosis was a crucial pathological feature of diabetic nephropathy (DN), and renal tubular injury might associate with abnormal mitophagy. In this study, we investigated the effects molecular mechanisms AMPK agonist metformin on mitophagy cellular in cell under condition. The high fat diet (HFD) streptozotocin (STZ)-induced type 2 mice model HK-2 cells were used study. Metformin administered drinking water (200 mg/kg/d) for 24 weeks. lesions, oxidative...
Tumor-targeted delivery of photothermal agent and controlled release concomitant chemotherapeutic drug are two key factors for combined chemotherapy. Herein, we developed a pH/near-infrared (NIR) dual-triggered nanoplatform based on hyaluronic acid (HA)-functionalized gold nanorods (GNRs) actively targeted synergetic chemotherapy breast cancer. Targeting folate (FA), dopamine, adipic dihydrazide triconjugated HA was first synthesized used to decorate GNRs via Au–catechol bonds, then an...
Abstract Objectives In diabetic nephropathy (DN), hypoxia‐inducible factor‐1α (HIF‐1α) activation in tubular cells plays an important protective role against kidney injury. The effects may occur via the target genes of HIF‐1α, such as haem oxygenase‐1 (HO‐1), but exact mechanisms are incompletely understood. Materials and methods Mice with proximal tubule‐specific knockout HIF‐1α (PT‐HIF‐1α −/− mice) were generated, diabetes was induced these mice by streptozotocin (STZ) injection. addition,...
Abstract Autophagy-mediated lipotoxicity plays a critical role in the progression of diabetic nephropathy (DN), but precise mechanism is not fully understood. Whether lipophagy, selective type autophagy participates renal ectopic lipid deposition (ELD) and kidney DN unknown. Here, decreased increased ELD lipotoxcity were observed tubular cells patients with DN, which accompanied reduced expression AdipoR1 p-AMPK. Similar results found db/db mice, these changes reversed by AdipoRon, an...
Mitochondria-associated endoplasmic reticulum membrane (MAM) may have a role in tubular injury diabetic nephropathy (DN), but the precise mechanism remains unclear. Here, we demonstrate that expression of phosphofurin acidic cluster sorting protein 2 (PACS-2), critical regulator MAM formation, is significantly decreased renal tubules patients with DN, and PACS-2 positively correlated function negatively degrees tubulointerstitial lesions. Conditional deletion Pacs-2 proximal (PTs) aggravates...
Abstract Background Septic acute kidney injury (S-AKI) is the leading form of failure among hospitalized patients, and inflammatory response involved in this process. 4-octyl itaconate (4-OI) a multi-target derivative with potent anti-inflammatory action. However, it remains elusive whether how 4-OI contributes to regulation S-AKI. Methods We employed lipopolysaccharide (LPS)-induced AKI murine model explored potential renoprotective effect vivo . In vitro experiments, BUMPT cells, renal...
Abstract Background The co-infection of human immunodeficiency virus (HIV)/acquired immune deficiency syndrome (AIDS) and tuberculosis (TB) poses a significant clinical challenge is major global public health issue. This study aims to elucidate the disease burden HIV-TB in global, regions countries, providing critical information for policy decisions curb epidemic. Methods ecological time-series used data from Global Burden Disease (GBD) Study 2021. encompass numbers incidence, prevalence,...
Tuberculosis (TB) is a major infectious disease with significant public health implications. Its widespread transmission, prolonged treatment duration, notable side effects, and high mortality rate pose severe challenges. This study examines the epidemiological characteristics of TB globally across regions, providing scientific basis for enhancing prevention control measures worldwide.
BackgroundThe mitochondrial associated endoplasmic reticulum (ER) membrane (MAM) provides a platform for communication between the mitochondria and ER, it plays vital role in many biological functions. Disulphide-bond A oxidoreductase-like protein (DsbA-L), expressed MAM, serves as an antioxidant reduces ER stress. However, of DsbA-L MAM kidney pathobiology remains unclear.MethodsMolecular biology techniques, transmission electron microscopy (TEM), situ proximity ligation assays (PLAs),...
This study aimed to assess the effect and mechanism of SS31 on cisplatin-induced acute kidney injury (CP-AKI) both in vivo vitro. Male mices HK-2 cells were treated using cisplatin establish models CP-AKI. 32 C57BL/6 randomly divided into four groups (control group, CP + normal saline SS-31 group). Cisplatin was intraperitoneally injected once mice (25 mg/kg). administrated for 10 days at dosages mg/kg per day. Kidney histological changes level reactive oxygen species(ROS) detected. In vitro...
Background: Vitamin D status has been linked to diabetes-related complications due multiple extraskeletal effects. We aimed investigate the association between vitamin deficiency (VDD) and diabetic vascular complications, including retinopathy (DR), kidney disease (DKD), foot ulcers (DFU). Methods: A total of 4284 Chinese patients with type 2 mellitus (T2DM) were enrolled into cross-sectional study. VDD was defined as serum 25-hydroxyvitamin <50 nmol/L. Demographic data, physical...
Renal tubular injury is an early characteristic of diabetic nephropathy (DN) that related to mitochondrial dysfunction. In this study, we explore the effects and mechanisms mitochondria-targeted peptide SS31 on renal tubulointerstitial in DN. 40 C57BL/6 mice were randomly divided into control group, STZ STZ+SS31 STZ+normal saline group. was intraperitoneally injected every other day for 24 weeks. lesions expression Drp1, Mfn1, Bcl-2, Bax, Caspase1, IL-1β, FN detected. vitro studies, HK-2...
Abstract Cisplatin (Cis) can cause chronic kidney disease (CKD) and promote renal fibrosis, but the underlying mechanism is not fully understood. Hypoxia inducible factor-1α (HIF-1α) fibrosis in some diseases, its role Cis-induced CKD still unknown. Notch-1 a recognized molecule that promotes under pathological circumstances, evidence shows HIF-1α are closely related to each other. In present study, mice with gene knockout proximal tubular cells (PTCs) (PT-HIF-1α-KO) were generated treated...