A5003365260- Tuberculosis Research and Epidemiology
- Asthma and respiratory diseases
- Pneumocystis jirovecii pneumonia detection and treatment
- Diagnosis and treatment of tuberculosis
- Acute Ischemic Stroke Management
- Mycobacterium research and diagnosis
- Disaster Response and Management
- Emergency and Acute Care Studies
- Infectious Diseases and Tuberculosis
- Cerebrovascular and Carotid Artery Diseases
- Sepsis Diagnosis and Treatment
- IL-33, ST2, and ILC Pathways
- interferon and immune responses
- Influenza Virus Research Studies
- Immune cells in cancer
- Traumatic Brain Injury and Neurovascular Disturbances
- Pharmacological Effects of Natural Compounds
- Inflammasome and immune disorders
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Posttraumatic Stress Disorder Research
- Liver Disease Diagnosis and Treatment
- Pneumonia and Respiratory Infections
- Autophagy in Disease and Therapy
- Intracerebral and Subarachnoid Hemorrhage Research
- Cardiac Arrest and Resuscitation
Longhua Hospital Shanghai University of Traditional Chinese Medicine
2017-2025
Shanghai University of Traditional Chinese Medicine
2017-2025
Capital Medical University
2021-2025
Beijing Tongren Hospital
2021-2025
Hebei General Hospital
2024
Peking University
2023
Tongren Hospital
2023
Capital University
2023
Beijing Jishuitan Hospital
2023
Tianjin Medical University
2023
Severe traumatic brain injury (TBI) has been increasing with greater incidence of injuries from traffic or sporting accidents. Although there are a number animal models TBI using progesterone for head injury, the effects on neurologic outcome acute patients remain unclear. The aim present clinical study was to assess longer-term efficacy improvement in severe TBI.A total 159 who arrived within 8 hours Glasgow Coma Score </= were enrolled study. A prospective, randomized, placebo-controlled...
Abstract Background The co-infection of human immunodeficiency virus (HIV)/acquired immune deficiency syndrome (AIDS) and tuberculosis (TB) poses a significant clinical challenge is major global public health issue. This study aims to elucidate the disease burden HIV-TB in global, regions countries, providing critical information for policy decisions curb epidemic. Methods ecological time-series used data from Global Burden Disease (GBD) Study 2021. encompass numbers incidence, prevalence,...
Tuberculosis (TB) is a major infectious disease with significant public health implications. Its widespread transmission, prolonged treatment duration, notable side effects, and high mortality rate pose severe challenges. This study examines the epidemiological characteristics of TB globally across regions, providing scientific basis for enhancing prevention control measures worldwide.
Metagenomic Next-Generation Sequencing (mNGS) has been applied as a novel method of detection pathogens for infectious diseases, but its value in the rapid diagnosis tuberculous meningitis(TBM)has not clarified based on large samples.A retrospective analysis was conducted 51 inpatients with suspected TBM who underwent mNGS and four other tests cerebrospinal fluid (CSF).Among included patients, 45 cases were diagnosed (38 definite, 5 probable, 2 possible) 6 non-TBM. Using final reference...
The Mycobacterium tuberculosis (Mtb) proteasome has been established as a viable target for the development of anti-tuberculosis agents. In this study, inhibitory activities 100 plant-derived natural products on Mtb were analyzed to identify novel potential inhibitors.The fluorescent substrate Suc-Leu-Leu-Val-Tyr-AMC can be hydrolyzed by release free AMC, fluorescence which is proportional activity. (each at final concentration 200 μM) detected method using MG132 positive control.Twelve...
Abstract A major obstacle to therapy in intensive care units is sepsis caused by severe infection. In recent years gram-positive (G + ) bacteria, most commonly staphylococci, are thought be the main pathogens. Micheliolide (MCL) was demonstrated provide a therapeutic role rheumatoid arthritis, inflammatory intestinal disease, colitis-associated cancer, and lipopolysaccharide (LPS, component of G − bacterial cell wall) induced septic shock. We proved here that MCL played an anti-inflammatory...
Better ways to prevent the cold ischemia-warm reperfusion (CI/WR) injury associated with liver transplantation are needed, and many investigations have focused on molecular mechanisms of this injury. However, reported date controversial no improvement in therapy has resulted. Here, using prolonged CI orthotopic rat grafts, we found that CI/WR was closely autophagy. By 15 minutes after start WR, small masses hepatocytes possessed abundant autophagosomes autolysosomes frequently dissociated...
Abstract Background China is the second highest pulmonary tuberculosis (PTB) burden country worldwide. However, retreatment of PTB has often developed resistance to at least one four first-line anti-TB drugs. The cure rate (approximately 50.0–73.3%) and management in needs be improved. Qinbudan decoction been widely used treat since 1960s. Previously clinical studies have shown that tablet (QBDT) promoted sputum-culture negative conversion lesion absorption. powerful evidence from a...
Abstract Background The coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has led to a significant number of mortalities worldwide. COVID-19 poses serious threat human life. clinical manifestations are diverse and 20% infected patients reported be in critical condition. A loss lung function pulmonary fibrosis the main with form disease. is affected, even after recovery, thereby greatly affecting psychology well-being patients,...
The COVID-19 pandemic has brought various opportunities and challenges to critical care nurses, whose emergency abilities in caring for critically ill patients are related their safety, clinical effectiveness, improved prognosis. Currently, there is a lack of research on the actual situation influencing factors ICU nurses' ability during pandemic. Although empirical observations from different departments can provide valuable basis health system formulate preventive measures, efficient...
ABSTRACT Background Asthma presents a significant challenge to the global healthcare systems and imposes heavy socioeconomic burden. Previous studies had geographical limitations lacked comprehensive analysis. The study utilises data from 2021 Global Burden of Disease ( GBD ) assess global, regional, national burden asthma 1990 2021. It examines disease trends, highlights health inequalities aims provide scientific evidence for future public strategies optimisation resource allocation....
Cold ischemia-warm reperfusion injury of liver grafts has been investigated thoroughly, but its underlying mechanism remains poorly understood. Here we show that autophagy is involved not only during cold preservation also warm following transplantation. Immunohistochemistry using an antibody against LC3, a microtubule associated protein 1 light chain 3 and marker autophagosomes, showed dot-like weak staining in hepatocytes rat preservation. Since University Wisconsin solution for graft...
As China is one of high MDR-TB burden countries, it important to determine the drug resistant pattern and clinical characteristics multidrug tuberculosis (MDR-TB). We conducted a comprehensive nationwide study on in 17 provinces for period from June 2009 2015, total 1154 cases were finally investigated. The sought assess features contrast susceptibility profiles patients China. Cavitary disease, young age, long duration TB disease among predictors. A resistance proportion first-line drugs...
<b><i>Background:</i></b> Hypertension and hyperhomocysteinemia (HHcy) are independent risk factors of stroke associated with each other. Although evidence suggests that they related to cognitive impairment, the relationship between hypertension accompanied HHcy poststroke impairment (PSCI) is unclear. <b><i>Objective:</i></b> To define early after acute cerebral infarction. <b><i>Materials Methods:</i></b> Our study...
The aim of this study was to assess the clinical utility metagenomic next-generation sequencing (mNGS) on smear-negative extrapulmonary specimens collected in China.Specimens were tested by mNGS and other routine tests for tuberculosis (TB). diagnostic accuracy calculated compared with final diagnosis.The sensitivity found be significantly higher than sensitivities TB tests. Receiver operating characteristic curve analysis showed that achieved highest area under (AUC) value 0.79. positive...
Hepatocellular carcinoma (HCC) is a common malignant tumor worldwide, with high morbidity and mortality. Chronic infection hepatitis B virus (HBV) major risk factor for the development of hepatocellular majority (~80%) patients in China exhibit co‑morbidity HBV‑associated liver cirrhosis. The goal reliable early diagnostic prognostic techniques HCC remains unrealized. aim present study was to explore efficacy serum high‑sensitivity C‑reactive protein (hs‑CRP) tests diagnosis A cohort 493...
Blastocystis hominis (Bh) is zoonotic parasitic pathogen with a high prevalent globally, causing opportunistic infections and diarrhea disease. Human immunodeficiency virus (HIV) infection disrupts the immune system by depleting CD4+ T lymphocyte (CD4+ T) cell counts, thereby increasing Bh risk among persons living HIV (PLWH). However, precise association between HIV-related biological markers treatment processes remains poorly understood. Hence, purpose of study was to explore viral load...
The incidence of asthma has increased in recent decades. Although corticosteroids and bronchodilators are used clinical practice, the control remains a challenge. Allergic is characterized airway inflammation mediated by type 2 immune response. Group innate lymphoid cells (ILC2s) an important source cytokines IL-5 IL-13, which contribute to progress asthma. Jia-Wei-Yu-Ping-Feng-San (JWYPFS), traditional Chinese medicine, been widely treat China. In this study we investigated mechanisms...
Objective: Different types of barrier membranes have been used in periodontal applications for the technology guided tissue regeneration (GTR). The aim this study was to characterize biological effect novel calcium alginate film (CAF) on bone by using rabbit mandible defects model. Methods: A critical size defect (5 mm diameter) created bilateral corner 45 adult rabbits. were covered with CAF served as experimental group, or conventional collagen membrane (CCM) left empty controls. Animals...