A5031181053- Liver Disease Diagnosis and Treatment
- Cancer-related gene regulation
- Inflammatory mediators and NSAID effects
- RNA modifications and cancer
- Hepatitis B Virus Studies
- Helicobacter pylori-related gastroenterology studies
- Plant Stress Responses and Tolerance
- Wnt/β-catenin signaling in development and cancer
- MicroRNA in disease regulation
- Sphingolipid Metabolism and Signaling
- Rheumatoid Arthritis Research and Therapies
- Photosynthetic Processes and Mechanisms
- Pain Mechanisms and Treatments
- RNA Interference and Gene Delivery
- Renal and related cancers
- Veterinary medicine and infectious diseases
- Mycobacterium research and diagnosis
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Skin and Cellular Biology Research
- Autoimmune and Inflammatory Disorders Research
- Heat shock proteins research
- Macrophage Migration Inhibitory Factor
Second Xiangya Hospital of Central South University
2013-2025
Hunan University
2024-2025
Central South University
2013-2025
Harbin Medical University
2025
First Affiliated Hospital of Harbin Medical University
2025
The Fourth People's Hospital of Ningxia Hui Autonomous Region
2018-2025
Zhejiang University of Technology
2025
Weifang People's Hospital
2020-2024
Xian Yang Central Hospital
2024
First Affiliated Hospital of Hunan University of Traditional Chinese Medicine
2024
Abstract Polyamines can alleviate the inhibitory effects of salinity on plant growth by regulating photosynthetic efficiency. However, little information is available to explain specific mechanisms underlying contribution polyamines salt tolerance apparatus. Here, we investigated role putrescine (Put) apparatus cucumber seedlings under stress. We found that NaCl stress resulted in severe ion toxicity and oxidative chloroplasts. In addition, caused a significant increase saturated fatty acid...
Neuropathic pain represents a challenge to clinicians because it is resistant commonly prescribed analgesics due its largely unknown mechanisms. Here, we investigated descending dopaminergic pathway-mediated modulation of trigeminal neuropathic pain. We performed chronic constriction injury the infraorbital nerve from maxillary branch induce in mice. Our retrograde tracing showed that projection hypothalamic A11 nucleus spinal caudalis bilateral. Optogenetic/chemogenetic manipulation...
Prohibitin 1 (PHB1) is best known as a mitochondrial chaperone, and its role in cancer conflicting. Mice lacking methionine adenosyltransferase α1 (MATα1) have lower PHB1 expression, we reported that c‐MYC interacts directly with both proteins. Furthermore, MATα1 exert opposing effects on liver growth, prompting us to examine the interplay between PHB1, MATα1, PHB1's tumorigenesis. We found highly expressed normal hepatocytes bile duct epithelial cells down‐regulated most human...
Antibiotic resistance is the most important factor leading to failed Helicobacter pylori eradication therapy, and personalized treatment based on antibiotic susceptibility becoming increasingly important. To strengthen understanding of genotypic H. identify new loci, in this study, we identified phenotypic information for 60 clinical isolates compared concordance using whole-genome sequencing (WGS). Clarithromycin levofloxacin was almost perfect with resistance, kappa coefficients 0.867...
Geographic differences exist in the antibiotic resistance patterns of Helicobacter pylori. Personalized treatment regimens based on local or individual data are essential. We evaluated current status H. pylori Ningxia, analyzed resistance-related factors, and assessed concordance phenotypic genotypic resistance.Strains were isolated from gastric mucosa patients infected with Ningxia relevant clinical information was collected. Phenotypic susceptibility assays (Kirby-Bauer disk diffusion)...
Helicobacter pylori (H. pylori) is becoming more resistant to antibiotics, and the implementation of individualized therapy highly valuable for its eradication. This study aimed investigate efficacy safety treatment guided by antibiotic susceptibility testing (AST) with a 10-day or 14-day course eradication H. pylori. was prospective, open-label, single-center, quasi-randomized trial in which 220 participants were randomized into groups based on AST results as AST-10-day (n = 98) AST-14-day...
To analyze the distribution and drug resistance of pathogens in patients with postoperative infection following knee arthroplasty (TKA) for osteoarthritis (KOA) to explore effectiveness high-quality nursing interventions postoperatively. A retrospective analysis was conducted on clinical data from 87 KOA who underwent TKA developed wound infections (infection group) at first Affiliated Hospital Harbin Medical University July 2022 September 2024. Another without during same period were...
Abstract 3‐Amino‐1‐adamantanol (3AA) is an important intermediate of vildagliptin. In this work, a fully continuous flow synthesis 3‐amino‐1‐adamantanol has been proposed. Selecting amantadine sulfate (AS) as the starting material, effects process parameters were systematically investigated, such molar ratio reactants, amount sulfuric acid and reaction temperature. The kinetics nitration carried out in both batch processes to explain relationship between rate constant. Based on apparent...
BACKGROUND Serine hydroxymethyltransferase 2 (SHMT2) is a key enzyme in one-carbon cell metabolism, including liver cancer. However, the associations between SHMT2 expression at gene and protein level prognosis patients with hepatocellular carcinoma (HCC) remains unknown. This study aimed to investigate levels of tumor tissue samples from HCC clinical outcome effects silencing HepG2 cells. MATERIAL AND METHODS Expression were evaluated 144 cases using immunohistochemistry correlated...
The WNT-beta-catenin pathway is known to regulate cellular homeostasis during development and tissue regeneration. Activation of WNT signaling increases the stability cytoplasmic beta-catenin enhances its nuclear translocation. Nuclear function regulated by transcriptional co-factors such as CREB binding protein (CBP) p300. Hyper-activated associated with many cancers. However, role in inducing stemness liver cancer cells, autoregulation how it regulates tumor suppressor pathways are not...
Toxoplasma gondii, a single-celled parasite commonly found in mammals, has been shown to induce trophoblast cell apoptosis and subsequently cause fetal damage abortion. Although dense granule protein 15 (GRA15) identified as key component innate immunity T. gondii infection its pathogenesis, role host remains unclarified. Type II GRA15 (GRA15II) cDNA was inserted into plasmid encoding enhanced green fluorescent (pEGFP). Choriocarcinoma JEG-3 cells were transfected with either pEGFP or...
Allium cepa is used for the prevention and treatment of hyperlipidemia-related diseases such as atherosclerosis in folk. This study was mainly aimed at investigating effects A. extract (ACE) enriched polyphenols on hyperlipidemia Sprague-Dawley (SD) experiment rat models. The levels total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL-C), high-density (HDL-C), malondialdehyde (MDA), superoxide dismutase (SOD) activity serum liver were measured using ELISA kits. In...