A5075503256- Prostate Cancer Treatment and Research
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- SARS-CoV-2 and COVID-19 Research
- Animal Virus Infections Studies
- Gut microbiota and health
- Cancer-related molecular mechanisms research
- Viral gastroenteritis research and epidemiology
- Genetic Associations and Epidemiology
- Clostridium difficile and Clostridium perfringens research
- Bioinformatics and Genomic Networks
- Ferroptosis and cancer prognosis
- COVID-19 Clinical Research Studies
- Liver Disease Diagnosis and Treatment
- Virus-based gene therapy research
- Cancer-related gene regulation
- Bat Biology and Ecology Studies
- Physiological and biochemical adaptations
- Respiratory viral infections research
- MicroRNA in disease regulation
- Viral Infections and Vectors
- Cancer-related Molecular Pathways
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Cancer, Lipids, and Metabolism
- Reproductive System and Pregnancy
Daqing Oilfield General Hospital
2025
Guangxi Medical University
2015-2024
Sichuan University
2024
West China Second University Hospital of Sichuan University
2024
Shanghai Institute of Technology
2023
Université de Lille
2023
City University of Macau
2023
Xinyang Normal University
2023
King's College London
2023
The London College
2023
The ongoing outbreak of viral pneumonia in China and across the world is associated with a new coronavirus, SARS-CoV-21. This has been tentatively seafood market Wuhan, China, where sale wild animals may be source zoonotic infection2. Although bats are probable reservoir hosts for SARS-CoV-2, identity any intermediate host that have facilitated transfer to humans unknown. Here we report identification SARS-CoV-2-related coronaviruses Malayan pangolins (Manis javanica) seized anti-smuggling...
Abstract The ongoing outbreak of viral pneumonia in China and beyond is associated with a novel coronavirus, provisionally termed 2019-nCoV. This has been tentatively seafood market Wuhan, China, where the sale wild animals may be source zoonotic infection. Although bats are likely reservoir hosts for 2019-nCoV, identity any intermediate host facilitating transfer to humans unknown. Here, we report identification 2019-nCoV related coronaviruses pangolins ( Manis javanica ) seized...
The sustained proliferation of microglia is a key hallmark Alzheimer's disease (AD), accelerating its progression. Here, we aim to understand the long-term impact early and prolonged microglial observed in AD, hypothesizing that extensive repeated cycling would engender distinct transcriptional phenotypic trajectory. We show seen an AD-like model promotes replicative senescence, characterized by increased βgal activity, senescence-associated signature, telomere shortening, correlating with...
Using a Drosophila model of Alzheimer's disease (AD), we systematically evaluated 67 candidate genes based on AD-associated genomic loci (P < 10−4) from published human genome-wide association studies (GWAS). Genetic manipulation 87 homologous fly was tested for modulation neurotoxicity caused by Tau, which forms neurofibrillary tangle pathology in AD. RNA interference (RNAi) targeting 9 enhanced Tau neurotoxicity, and most cases reciprocal activation gene expression suppressed toxicity. Our...
Abstract Pangolins are the most trafficked wild animal in world according to World Wildlife Fund. The discovery of SARS-CoV-2-related coronaviruses Malayan pangolins has piqued interest viromes these wild, scaly-skinned mammals. We sequenced 161 that were smuggled into China and assembled 28 vertebrate-associated viruses, 21 which have not been previously reported vertebrates. named 16 members Hunnivirus , Pestivirus Copiparvovirus pangolin-associated viruses. report l -protein lost from all...
<h3>Objective</h3> Tumour biomarkers are used as indicators for cancer screening and predictors therapeutic responses prognoses in patients. We aimed to identify genetic loci that influence concentrations of antigen 19-9 (CA19-9), carcinoembryonic (CEA) α fetoprotein (AFP), investigated the associations between significant single nucleotide polymorphisms (SNPs) with risks oesophageal squamous cell (OSCC), pancreatic hepatocellular cancers. <h3>Design</h3> carried out a genome wide...
Prostate cancer (PCa) is one of the most common epithelial malignant tumors and fifth leading cause death in men.An increasing number studies have demonstrated that N6-methyladenosine (m 6 A) plays a crucial role tumorigenesis tumor development.However, little known about levels m A regulators PCa.In this study, we analyzed characteristic expression PCa castration-resistant prostate (CRPC).UALCAN cBioPortal were used to estimate clinical value genetic alterations regulators, respectively.The...
Abstract Human endogenous retroviruses (HERVs) are the remnants of ancient retroviral infections integrated into human genome. Although most HERVs silenced or rendered inactive by various regulatory mechanisms, they retain potential to influence nearby genes. We analyzed map 91 HERV-Ks on neighboring genes in breast cancer and investigated impact tumor microenvironment (TME) prognosis cancer. Nine RNA-seq datasets were obtained from GEO NCBI SRA. Differentially expressed using DESeq2....
Complement C3 and C4 play key roles in the main physiological activities of complement system, their deficiencies or over-expression are associated with many clinical infectious immunity diseases. A two-stage genome-wide association study (GWAS) was performed for serum levels C4. The first stage conducted 1,999 healthy Chinese men, second an additional 1,496 subjects. We identified two SNPs, rs3753394 CFH gene rs3745567 gene, that significantly at a significance level (P = 7.33×10−11 P...
<h3>Background</h3> Sex hormones and gonadotropins exert a wide variety of effects in physiological pathological processes. Accumulated evidence shows strong heritable component circulating concentrations these hormones. Recently, several genome-wide association studies (GWASs) conducted Caucasians have identified multiple loci that influence serum levels sex However, the genetic determinants remain unknown Chinese populations. In this study, we aimed to identify variants associated with...
Coronary heart disease seriously jeopardizes human health and has become a principal public problem of global concern. While percutaneous coronary intervention (PCI) repairs narrowed arteries extends patients' lives, cardiac rehabilitation offers additional benefits post-PCI. Numerous previous studies have shown that can inhibit the progression atherosclerotic plaques in patients after intervention, effectively controlling clinical symptoms improving their quality life. However, current...
Ticks are the second most important vectors of arboviruses after mosquitoes, and they also serve as reservoir hosts for some zoonotic diseases. It is essential to understand prevalence tick-borne viruses in ticks from different sampling sites vectors, this information can facilitate surveillance prevention arboviral infectious We systematically collected a variety animals, including wildlife domestic livestock, across 18 distinct regions Guangxi Zhuang Autonomous Region(Guangxi). then...
<b>Study question</b> Can avian influenza A (H7N9) virus be transmitted between unrelated individuals in a hospital setting? <b>Methods</b> An epidemiological investigation looked at two patients who shared ward February 2015, Quzhou, Zhejiang Province, China. Samples from the patients, close contacts, and local environments were examined by real time reverse transcriptase (rRT) polymerase chain reaction (PCR) viral culture. Haemagglutination inhibition microneutralisation assays used to...
Abstract Background The prevalence of human immunodeficiency type 1 (HIV-1) pretreatment drug resistance (PDR) in men who have sex with (MSM) Guangxi remains unclear, and its effect on antiretroviral therapy (ART) needs to be further studied. Methods Individuals newly diagnosed HIV from 2016 2020, which mainly included MSM the heterosexual (HES) population, were recruited this study. Pol sequences sequenced analyze PDR construct a genetic network. risk factors for ART respectively analyzed....
Prostate cancer is one of the most commonly diagnosed male malignancies.Genome wide association studies have revealed HNF1b to be a major risk gene for prostate susceptibility.We examined mechanisms involvement in development.We integrated data from Gene Expression Omnibus genes Dragon Database Genes Implicated Cancer, and used meta-analysis generate panel HNF1b-associated genes.An RT-PCR was assess expression levels DU145, PC3, LNCaP, ©FUNPEC-RP www.funpecrp.com.
Background Serum carcinoembryonic antigen (sCEA) level might be an indicator of disease. Indeed, elevated sCEA is a prognostic factor in colorectal cancer (CRC) patients. However, the genetic determinants healthy and CRC population remains unclear. Thus we investigated markers associated with serum these two populations its clinical implications. Methods Findings Genome-wide association study (GWAS) was conducted cohort 4,346 male adults using Illumina Omni 1 M chip. Candidate SNPs levels...
AIM:To investigate the associations between polymorphisms of cell cycle pathway genes and risk hepatocellular carcinoma (HCC). METHODS:We enrolled 1127 cases newly diagnosed with HCC from Tumor Hospital Guangxi Medical University 1200 non-tumor patients First Affiliated University.General demographic characteristics, behavioral information, hematological indices were collected by unified questionnaires.Genomic DNA was isolated
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of ongoing disease 2019 (COVID-19) pandemic. Understanding influence mutations in SARS-CoV-2 gene on clinical outcomes critical for treatment and prevention. Here, we analyzed all high-coverage complete sequences from GISAID database January 1, 2020, to 2021, mine mutation hotspots associated with outcome developed a model predict different epidemic strains. Exploring based RNA-dependent RNA polymerase (RdRp)...
Human endogenous retroviruses (HERVs) make up 8% of the human genome. HERVs are biologically active elements related to multiple diseases. HERV-K, a subfamily HERVs, has been associated with certain types cancer and suggested as an immunologic target in some tumors. The expression levels HERV-K breast (BCa) have studied biomarkers therapeutic targets. However, copies genome, few studies determined transcriptional profile across genome for BCa.Ninety-one indexes entire proviral sequences were...