A5013308863- Toxoplasma gondii Research Studies
- Cytomegalovirus and herpesvirus research
- Parasitic Infections and Diagnostics
- Herpesvirus Infections and Treatments
- Parasites and Host Interactions
- Heme Oxygenase-1 and Carbon Monoxide
- interferon and immune responses
- Autophagy in Disease and Therapy
- Mosquito-borne diseases and control
- Liver physiology and pathology
- Parasitic Diseases Research and Treatment
- Parasite Biology and Host Interactions
- Macrophage Migration Inhibitory Factor
- Immune Response and Inflammation
- Research on Leishmaniasis Studies
- Liver Disease Diagnosis and Treatment
- Bacteriophages and microbial interactions
- Inflammasome and immune disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Antimicrobial Resistance in Staphylococcus
- Malaria Research and Control
- RNA modifications and cancer
- Galectins and Cancer Biology
- RNA Interference and Gene Delivery
- Rabies epidemiology and control
Anhui Medical University
2016-2025
First Affiliated Hospital of Anhui Medical University
2016-2025
Fourth Affiliated Hospital of Anhui Medical University
2022
First Affiliated Hospital of Bengbu Medical College
2021
Center for Disease Control
2021
Qilu Hospital of Shandong University
2021
Suzhou Traditional Chinese Medicine Hospital
2016
Nanjing Medical University
2016
Chinese People's Liberation Army
2014
The 309th Hospital of Chinese People's Liberation Army
2014
Background Recent population structure studies of T. gondii revealed that a few major clonal lineages predominated in different geographical regions. South America is genetically and biologically divergent, whereas this parasite remarkably North Europe with including Types I, II III. Information on genotypes mouse virulence isolates from China scarce insufficient to investigate its structure, evolution, transmission. Methodology/Principal Findings Genotyping 23 hosts using 10 markers for...
The gut and brain interact through various metabolic signaling pathways, each of which influences mental health. Gut dysbiosis caused by antibiotics is a well-known phenomenon that has serious implications for microbiota-brain interactions. Although disrupt the microbiota’s fundamental structure, mechanisms modulate response their impact on function are still unclear. It imperative to comprehend investigate crucial regulators factors play important roles. We aimed study effect long-term...
Helminth infections and their components have been shown to a protective effect on autoimmune diseases. The isolated purified protein from Schisotosoma japonicum its potential therapeutic trinitrobenzene sulfonic acid (TNBS)-induced colitis could provide an alternative way treat inflammatory bowel disease (IBDs). Colitis was induced in Balb/c mice by rectal administration of 2.5 % TNBS, followed intraperitoneal injection rSjcystatin 50 μg at 6 h 24 afterwards. inflammation monitored...
Toxoplasma gondii is an intracellular protozoan that affects most species of endothermic animals including humans with a great infection rate. The vertical transmission T. causes abortion, constituting serious threat to and leading losses in livestock production. Distinct from population structure North America Europe, Chinese 1 (ToxoDB #9) dominant genotype prevalent China. Among the isolates 1, Wh3 Wh6 have different virulence pathogenicity mice. However, little has been known about their...
The aim of the present study was to investigate synergistic effects and interactive mechanisms Shufeng Jiedu Capsule (SFJDC) combined with oseltamivir in treatment acute exacerbation chronic obstructive pulmonary disease (AECOPD) induced by influenza A virus (IAV). extraction SFJDC analyzed UHPLC/ESI Q-Orbitrap Mass Spectrometry. Human bronchial epithelial cells were isolated from COPD (DHBE) tissues, co-cultured IAV for 24 h, subsequently treated and/or oseltamivir. Cell viability detected...
m6A is the most prevalent and abundant form of mRNA modifications closely related to tumor proliferation, differentiation, tumorigenesis. In this study, we try conduct an effective prediction model investigated function RNA methylation modulators in pancreatic adenocarcinoma estimated potential association between microenvironment infiltration for optimization treatment.Expression 28 clinical data patients with normal samples were obtained from TCGA GTEx database. Differences expression...
Thelazia callipaeda, commonly known as the 'oriental eyeworm', has been recently reported in Italy and other European countries. The insect/s that act intermediate hosts details of larval development inside vector remain unclear. In order to (1) demonstrate species fly may vector/s for T. callipaeda southern (Site A) China B) (2) describe nematode body flies, 847 Phortica (Drosophilidae) flies were collected from above two sites, each with a history human and/or canine thelaziosis. Flies...
Toxoplasma gondii infection in pregnant women may result abortion or fetal teratogenesis; however, the underlying mechanisms are still unclear. In this paper, based on a murine model, we showed that maternal with RH strain T. tachyzoites induced elevated production of reactive oxygen species (ROS), local oxidative stress, and subsequent apoptosis placental trophoblasts. PCR array analysis 84 stress-related genes demonstrated 27 were upregulated at least 2-fold 9 downregulated group compared...
Toxoplasma gondii (T. gondii) is a very successful parasite that can infect virtually all warm blooded animals with worldwide distribution. It causes large range of clinical manifestations in both humans and domesticated animals. In addition, marked biological differences exist among T. strains the pathogenicity geographical Molecular epidemiology studies primarily based on restriction fragment length polymorphism (RFLP) method revealed three main types are predominant North America Europe,...
A plethora of evidence shows that activated microglia play a critical role in the pathogenesis central nervous system (CNS). Toxoplasmic encephalitis (TE) frequently occurs HIV/AIDS patients. However, knowledge remains limited on contributions to TE. murine model reactivated was generated latent infection with Toxoplasma gondii induced by cyclophosphamide. The neuronal apoptosis CNS and profile pro-inflammatory cytokines were assayed both vitro vivo experiments. Microglial cells found be...
The apicomplexan parasite Toxoplasma gondii can infect and replicate in virtually any nucleated cell many species of warm-blooded animals; T. has elaborate mechanisms to counteract host-cell apoptosis order maintain survival breed the host cells.Using microarray profiling a combination conventional molecular approaches, we investigated levels microRNAs (miRNAs ) human macrophage during infection. We used tools examine Toxoplasma-upregualted miRNAs revealed potential signal transducers...
SUMMARY Toxoplasma gondii is a major cause of congenital brain disease; however, the underlying mechanism neuropathogenesis in toxoplasmosis remains elusive. To explore role T. development neural stem cells (NSCs), NSCs were isolated from GD14 embryos ICR mice and co-cultured with tachyzoites RH strain. We found that apoptosis levels 1×10 6 for 24 48 h significantly increased dose-dependent manner, as compared control. Western blotting analysis displayed protein level C/EBP homologous (CHOP)...
Upconversional core-shell nanostructures have gained considerable attention due to their distinct enhanced fluorescence efficiency, multifunctionality, and specific applications. Recently, we developed a sequential growth process fabricate unique upconversion nanoparticles. Time evolution of morphology for the NaYF4:Yb/Er@NaGdF4 nanodumbbells has been extensively investigated. An Ostwald ripening mechanism proposed illustrate formation nanodumbbells. The hydrophilic exhibited strong showed...
Although Toxoplasma virulence mechanisms targeting gamma interferon (IFN-γ)-induced cell-autonomous antiparasitic immunity have been extensively characterized in mice, the humans remain uncertain, partly because immune responses against differ markedly between mice and humans. Despite identification of inducible nitric oxide synthase (iNOS) as an anti-Toxoplasma host factor here we show that iNOS is a pro-Toxoplasma promotes growth parasite. The GRA15 effector-dependent disarmament...
Influenza A virus (IAV) triggers acute exacerbation of chronic obstructive pulmonary disease (AECOPD), but the molecular mechanisms remain unclear. In this study, we investigated role IAV induced NLRP3 inflammasome activation to increase airway inflammation response in progression AECOPD.Human bronchial epithelial cells were isolated and cultured from normal COPD tissues co-cultured with IAV. The associated genes identified using RNA sequencing, expressions components measured qRT-PCR...