A5103068378- Toxoplasma gondii Research Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Organ Transplantation Techniques and Outcomes
- Mitochondrial Function and Pathology
- Anesthesia and Pain Management
- Autophagy in Disease and Therapy
- Liver physiology and pathology
- Endoplasmic Reticulum Stress and Disease
- Cardiac Ischemia and Reperfusion
- Liver Disease Diagnosis and Treatment
- Anesthesia and Neurotoxicity Research
- Anesthesia and Sedative Agents
- Intensive Care Unit Cognitive Disorders
- Phagocytosis and Immune Regulation
- Nausea and vomiting management
- Parasitic Infections and Diagnostics
- Herpesvirus Infections and Treatments
- Macrophage Migration Inhibitory Factor
- Cardiac Arrest and Resuscitation
- Hepatitis Viruses Studies and Epidemiology
- Hemodynamic Monitoring and Therapy
- Metabolomics and Mass Spectrometry Studies
- Epigenetics and DNA Methylation
- Renal function and acid-base balance
- Hepatitis B Virus Studies
First Affiliated Hospital of Anhui Medical University
2016-2025
Anhui Medical University
2016-2025
Southern Medical University
2023-2024
National Center For Child Health and Development
2023
Hunan Children's Hospital
2022-2023
China Nonferrous Metals Changsha Investigation Design Institute
2022
State Key Laboratory of Respiratory Disease
2016
Guangzhou Medical University
2016
Shandong Agricultural University
2012
Abstract The reticulon family has been found to induce apoptosis, inhibit axon regeneration and regulate protein trafficking. However, little is known about the mechanisms of how proteins are involved in neuronal death-promoting processes during ischemia. Here, we report that expression Reticulon Protein 1-C (RTN1-C) was associated with progression cerebral ischemia/reperfusion (I/R) injury. Using a combination rat middle artery occlusion (MCAO) stroke oxygen-glucose deprivation followed by...
Abstract Background Some studies have shown that gut microbiota may be associated with dementia. However, the causal effects between and different types of dementia whether cytokines act as a mediator remain unclear. Methods Gut microbiota, cytokines, five types, including Alzheimer’s disease (AD), frontotemporal (FTD), Lewy body (DLB), vascular (VD), Parkinson’s (PDD) were identified from large-scale genome-wide association (GWAS) summary data. We used Mendelian randomization (MR) to...
Abstract Inflammation can cause endoplasmic reticulum (ER) stress and therefore activates the unfolded protein response (UPR). ER consequent UPR have potential to activate NF-κB. However, factors mediating crosstalk between NF-κB pathway remain unclear. Here, we determined that inducible Mesencephalic Astrocyte-derived Neurotrophic Factor (MANF) was up-regulated in autoimmune diseases inflammatory disease models. caused MANF relocalize nuclei. interacted with DNA binding domain of p65...
Introduction: Music interventions can alleviate patient anxiety and improve post-surgical satisfaction. However, it remains uncertain whether music personal preferences affect efficacy. We tested intervention with patient-selected songs played ad libitum is more effective than standard therapist-designed treatment classical music. Methods: A prospective, parallel-group, single-blinded, randomized controlled trial 229 participants (aged 18 to 60 y) previously scheduled for elective surgery....
Background and Aims: The innate-like mucosa-associated invariant T (MAIT) cells are enriched in human liver have been linked to HCC. However, their contributions the progression of HCC controversial due heterogeneity MAIT cells, new cell subsets remain be explored. Approach Results: Combining single RNA sequencing (scRNA-seq) flow cytometry analysis, we performed phenotypic functional studies found that FOXP3 + CXCR3 patients were regulatory (MAITregs) with high immunosuppressive potential....
Abstract Macrophage therapy for liver fibrosis is on the cusp of meaningful clinical utility. Due to heterogeneities macrophages, it urgent develop safer macrophages with a more stable and defined phenotype treatment fibrosis. Herein, new macrophage‐based immunotherapy using stably expressing pivotal cytokine from Toxoplasma gondii , parasite that infects ≈ 2 billion people developed. It found macrophage migration inhibitory factor‐transgenic (Mφ tgmif ) shows fibrinolysis strong chemotactic...
Remifentanil-induced hyperalgesia (RIH) is a severe but common postoperative clinical problem with elusive underlying neural mechanisms. Here, we discovered that glutamatergic neurons in the thalamic ventral posterolateral nucleus (VPLGlu) exhibited significantly elevated burst firing accompanied by upregulation of Cav3.1 T-type calcium channel expression and function RIH model mice. In addition, identified neuronal thalamocortical circuit VPL projecting to hindlimb primary somatosensory...
Hepatic ischemia-reperfusion (I/R) injury can cause poor prognosis of liver transplantation and hepatectomy, especially in patients with alcohol-associated disease (ALD). Apoptosis is closely related to different stages injury, the death hepatocytes caused by endoplasmic reticulum (ER) mitochondria homeostasis perturbation may be key injury. The receptor tyrosine kinases AXL encoded gene axl, a member TAM (TYRO3, AXL, MERTK) family, which participates various biological processes binding...
Significance As a neurotropic parasite, Toxoplasma predominantly interacts with neurons throughout CNS infection and causes severe damage to the brain. In patients immune dysfunction, dormant encysted bradyzoites can reactivate into fast-replicating tachyzoites may cause We report that an endoplasmic reticulum (ER)-associated protein, RTN1-C, is substrate of ROP18 kinase. phosphorylation RTN1-C triggers ER stress-mediated apoptosis. Phosphorylated enhances GRP78 acetylation via attenuating...
Organophosphorus flame retardants (OPFRs), including 2-ethylhexyl diphenyl phosphate (EHDPHP), are prevalent in everyday life due to their broad usage fields such as healthcare, electronics, industry, and sports. These compounds, added polymers through physical mixing, can leach into the environment, posing a risk humans direct contact or food chain. Despite known associations with health issues like endocrine disruption, neurotoxicity, reproductive toxicity, implications of perinatal EHDPHP...
Objectives . Dexmedetomidine is widely used as an adjunct to general anesthesia. In this study, we evaluated the effects of perioperative dexmedetomidine infusion on postoperative analgesia in patients undergoing lateral thoracotomy for thoracic esophageal cancer. Methods A total 62 cancer were randomized receive adjuvant therapy with either (0.5 μ g/kg intravenous bolus injection 10 min before induction anesthesia, followed by continuous 0.2–0.4 g/kg/h until end surgery, and 0.06 5 days...
Remifentanil postconditioning (RPC) confers robust cardioprotection against ischemia/reperfusion (I/R) injury. We recently determined that HDAC3 was involved in RPC-induced cardioprotection. However, the role of and its possible mechanisms are unknown, which we aimed to evaluate an vitro hypoxia/reoxygenation (HR) model.Myocardium I/R injury established after HR with H9c2 cardiomyoblasts. Cell viability apoptosis were evaluated usingCCK-8 flow cytometry HR-injured cardiomyoblasts treated or...
Background: Acute kidney injury is the most common complication after liver transplantation. Sodium bicarbonate Ringer's solution a new type of crystalloid that has been recently used in clinical setting. Whether sodium reduces occurrence postoperative AKI and improves outcomes transplantation patients not clear. Objective: To compare effects versus normal saline on acute following classic orthotopic Methods: Sixty-four participants were randomly assigned to Ringers (BRS) group or (NS)...
EEG monitoring techniques are receiving increasing clinical attention as a common method of reflecting the depth sedation in perioperative period. The influence indices such bispectral index (BIS) generated by processed electroencephalogram (pEEG) machine to guide management anesthetic on postoperative outcome remains controversial. This research was designed decide whether an agent exposure determined raw (rEEG) can and cause different patterns affect various patient outcomes.A total 141...