A5100362098- Ubiquitin and proteasome pathways
- Endoplasmic Reticulum Stress and Disease
- Immune cells in cancer
- Autophagy in Disease and Therapy
- Hippo pathway signaling and YAP/TAZ
- Ferroptosis and cancer prognosis
- Cancer-related Molecular Pathways
- RNA Research and Splicing
- Pharmacological Effects of Natural Compounds
- Cancer Immunotherapy and Biomarkers
- Cancer, Hypoxia, and Metabolism
- Plant-based Medicinal Research
- Neurological Disease Mechanisms and Treatments
- Cancer-related gene regulation
- Protein Degradation and Inhibitors
- NF-κB Signaling Pathways
- interferon and immune responses
- Traditional Chinese Medicine Analysis
- Epigenetics and DNA Methylation
- Macrophage Migration Inhibitory Factor
- RNA modifications and cancer
- Cancer Research and Treatments
- Peptidase Inhibition and Analysis
- Ginseng Biological Effects and Applications
- Immune Cell Function and Interaction
Shanghai Tenth People's Hospital
2009-2025
Tongji University
2009-2025
Affiliated Hospital of Southwest Medical University
2025
Anhui Medical University
2016-2025
First Affiliated Hospital of GuangXi Medical University
2024-2025
Guangxi Medical University
2022-2025
Guangdong Medical College
2021-2025
Shanghai Skin Disease Hospital
2023-2024
Nanjing Agricultural University
2024
Second Hospital of Anhui Medical University
2019-2024
Hippo signaling is a tumor-suppressor pathway involved in organ size control and tumorigenesis through the inhibition of YAP TAZ. Here, we show that energy stress induces cytoplasmic retention S127 phosphorylation inhibits transcriptional activity YAP-dependent transformation. These effects require central metabolic sensor AMP-activated protein kinase (AMPK) upstream components Lats1/Lats2 angiomotin-like 1 (AMOTL1). Furthermore, AMPK directly phosphorylates S793 AMOTL1. activation...
Background and Aims Endoplasmic reticulum (ER) stress is associated with liver inflammation hepatocellular carcinoma (HCC). However, how ER links HCC remains obscure. Mesencephalic astrocyte‐derived neurotrophic factor (MANF) an stress‐inducible secretion protein that inhibits by interacting the key subunit of nuclear kappa light chain enhancer activated B cells (NF‐κB) p65. We hypothesized MANF may play a role in linking HCC. Approach Results Here, we found mRNA levels were lower tissues...
Premature senescence is an important event during diabetic nephropathy (DN) progression. Here, we investigated the role of endoplasmic reticulum (ER) stress-regulated activation transcription factor 4 (ATF4)/p16 signaling in premature renal tubular epithelial cells (RTECs) DN development. In tissues Type 2 patients, detected increased number senescent cells; elevated deposition advanced glycation end products (AGEs); upregulated expression ER stress marker, glucose-regulated protein 78; as...
Psoriasis is a chronic autoimmune inflammatory disease characterized by erroneous metabolism of keratinocytes. The development psoriasis closely related to abnormal activation and disorders the immune system. Dysregulated skin protective mechanisms can activate pathways within epithelial microenvironment (EIME), leading autoimmune-related diseases. In this review, we initially emphasized pathogenesis psoriasis, paying particular attention interactions between cells production cytokines in...
Background The Food and Drug Administration has approved the Serine/threonine-protein kinase B-raf (BRAF) inhibitor Mitogen-activated extracellular signal-regulated (MEK) combo as first-line treatment for individuals with metastatic melanoma, although majority of these patients exhibit primary or secondary drug resistance in clinic. Dihydrotanshinone I (DHT) is a lipophilic compound extracted from root Salvia miltiorrhiza that been linked to multiple antitumor activities. In this study, we...
Emerin, MAN1, and LAP2 are integral membrane proteins of the vertebrate nuclear envelope. They share a 43-residue N-terminal motif termed LEM domain. We found three putative domain genes inCaenorhabditis elegans, designated emr-1,lem-2, lem-3. analyzedemr-l, which encodes Ce-emerin, andlem-2, Ce-MAN1. Ce-emerin Ce-MAN1 migrate on SDS-PAGE as 17- 52-kDa proteins, respectively. Based their biochemical extraction properties immunolocalization, both localized at used antibodies against Ce-MAN1,...
Mutations in the Caenorhabditis elegans unc-84 gene cause defects nuclear migration and anchoring. We show that endogenous UNC-84 protein colocalizes with Ce-lamin at envelope localization of requires Ce-lamin. also during mitosis, remains periphery until late anaphase, similar to known inner membrane proteins. is first detected 26-cell stage thereafter present most cells development adults. properly expressed unc-83 andanc-1 lines, which have phenotypes tounc-84, suggesting neither...
The mesencephalic astrocyte-derived neurotrophic factor (MANF) has been recently identified as a factor, but its role in hepatic fibrosis is unknown. Here, we found that MANF was upregulated the fibrotic liver tissues of patients with chronic diseases and mice treated CCl4. deficiency either hepatocytes or mono-macrophages, particularly clearly exacerbated fibrosis. Myeloid-specific knockout increased population Ly6Chigh macrophages promoted HSCs activation. Furthermore, MANF-sufficient...
Abstract Background Epigenetic alterations play an important role in hepatocellular carcinoma (HCC) development. Enhancer of zeste homolog 2 (EZH2) is a well-known epigenetic modifier that functions as oncogene tumors by promoting the H3K27me3-mediated transcriptional repression tumor suppressor genes. “Senescent cells” has been proposed possible core component hallmarks cancer conceptualization. Induction cell senescence and targeted elimination these senescent cells are new strategies for...
Wnt/β-catenin signaling participates in the epithelial-mesenchymal transition (EMT) a variety of cancers; however, its involvement hepatocellular carcinoma (HCC) and downstream molecular events is largely undefined. HNF4α most prominent specific factor for maintaining differentiation hepatic lineage cells potential EMT regulator HCC cells. However, mechanisms by which maintains differentiated liver epithelium inhibits have not been completely defined. In this study, we systematically...
Background Although endoplasmic reticulum (ER) stress has been implicated in the pathophysiology of organ ischemia-reperfusion injury (IRI), underlying mechanisms have yet to be fully elucidated. In particular, because tissue proinflammatory immune response is key mediator local IRI, how ER impacts liver cell activation cascade remains determined. Methods vitro, macrophages and hepatocytes were induced by pharmacological agents. Macrophage Toll-like receptor 4 hepatocyte tumor necrosis...
In response to spinal surgery, neurons secrete a large amount of substance P into the epidural area. Substance is involved in macrophage differentiation and fibrotic disease. However, specific roles mechanisms fibrosis remain unclear. this study, we established mouse model L1-L3 laminectomy found that dorsal root ganglion macrophages infiltrating wound area released sphingolipids. vitro experiments revealed type 1 secreted P, which promoted towards 2 phenotype. High-throughput mRNA-seq...
Gliomas are the most common type of primary brain tumor. Despite advances in treatment, it remains one aggressive and deadly tumor central nervous system (CNS). characterized by high malignancy, heterogeneity, invasiveness, resistance to radiotherapy chemotherapy. It is urgent find potential new molecular targets for glioma. The TRPM channels consist TRPM1-TPRM8 play a role many cellular functions, including proliferation, migration, invasion, angiogenesis, etc. More more studies have shown...
Abstract The development of the cornea, a highly specialized transparent tissue located at anterior eye, is coordinated by variety molecules and cells. Here, we report that mast cells (MCs), recently found to be involved in morphogenesis, played potentially important role corneal mice. We show two different waves MC migration occurred during development. In first wave, MCs migrated stroma became distributed throughout cornea. This wave embryonic day 12.5, with disappearing from cornea time...
Endoplasmic reticulum (ER) perturbations are novel subcellular effectors involved in the ischaemia-reperfusion injury. As an ER stress-inducible protein, mesencephalic astrocyte-derived neurotrophic factor (MANF) has been proven to be increased during ischaemic brain However, role of MANF liver ischaemia reperfusion (I/R) injury not yet studied.To investigate process ischaemia-reperfusion, Hepatocyte-specific knockout (MANFhep-/- ) mice and their wild-type (WT) littermates were used our...