A5011245418- Kidney Stones and Urolithiasis Treatments
- Pediatric Urology and Nephrology Studies
- Cancer, Hypoxia, and Metabolism
- Mesenchymal stem cell research
- MicroRNA in disease regulation
- Urinary Bladder and Prostate Research
- Cancer-related gene regulation
- Catalytic C–H Functionalization Methods
- RNA modifications and cancer
- Autophagy in Disease and Therapy
- Cancer-related molecular mechanisms research
- Tissue Engineering and Regenerative Medicine
- Cannabis and Cannabinoid Research
- Renal cell carcinoma treatment
- Cancer Research and Treatments
- Ureteral procedures and complications
- Galectins and Cancer Biology
- Testicular diseases and treatments
- Wnt/β-catenin signaling in development and cancer
- Virus-based gene therapy research
- Pelvic floor disorders treatments
- Catalytic Alkyne Reactions
- Cancer Mechanisms and Therapy
- Extracellular vesicles in disease
- Higher Education and Teaching Methods
First Affiliated Hospital of Xiamen University
2012-2023
Yangpu Hospital of Tongji University
2022
Fujian Medical University
2012-2018
Guangzhou University of Chinese Medicine
2016
Xiamen University
2013-2015
Jiangsu Academy of Agricultural Sciences
2012
Jiaozuo University
2009
This study aimed to investigate the effect of over-expressing circular RNA CEP128 (circCEP128) on cell functions and explore molecular mechanism which in bladder carcinoma. The differentially expressed circRNAs mRNAs carcinoma cells adjacent tissues were screened out using microarray analysis. Expression levels determined by qRT-PCR. SOX11 was detected western blot. Luciferase reporter assay pull-down used interactions between specific circRNA, miRNA mRNA. Cell cycle apoptosis measured flow...
Exosomal microRNAs (miRNAs) are suggested to reflect molecular changes occurring in their cells of origin and potential indicators the early detection cancers. This study aimed determine whether certain exosomal miRNAs from tumor tissue can be used as noninvasive biomarkers for clear cell renal carcinoma (ccRCC). Based on ccRCC miRNA expression profiles literature, we selected six (miR-210, miR-224, miR-452, miR-155, miR-21, miR-34a) analyzed tissues, sera, serum exosomes through...
Wnt/β-catenin signaling participates in the epithelial-mesenchymal transition (EMT) a variety of cancers; however, its involvement hepatocellular carcinoma (HCC) and downstream molecular events is largely undefined. HNF4α most prominent specific factor for maintaining differentiation hepatic lineage cells potential EMT regulator HCC cells. However, mechanisms by which maintains differentiated liver epithelium inhibits have not been completely defined. In this study, we systematically...
Abstract A gold‐catalyzed intermolecular alkyne oxidation for the preparation of 3‐coumaranones has been developed. Using 8‐isopropylquinoline N ‐oxides as oxidants, reactions o ‐ethynylanisoles afford versatile in moderate to good isolated yields. The synthetic utility this chemistry is also indicated by synthesis natural product sulfuretin.
The present study investigated the role of androgen in process androgen‑induced prostate hyperplasia castrated rats and assessed phosphoinositide 3‑kinase/protein kinase B/mechanistic target rapamycin (PI3K/Akt/mTOR) pathway this process. Furthermore, extent to which autophagy may affect level benign prostatic was also explored. A total 40 Sprague Dawley were randomly divided into four groups: Testosterone group, 3‑methyladenine (3‑MA) control group. tissue apoptosis assayed. wet weight,...
Ureteroscopic lithotripsy has become the first choice for treatment of middle and lower ureteral stones, but it still a certain rate surgical failure. Here we aimed to determine factors that may affect success holmium laser ureterolithotripsy (HLU) provide basis guidance its future use.To evaluate risk HLU failure.The clinical data 385 patients undergoing from 2009 2012 were retrospectively reviewed analyze impact gender, age, stone side, size, location, number, degree hydronephrosis,...
Abstract Background Toll‐like receptor‐7 (TLR7) is functionally involved in the pathogenesis of Hunner‐type interstitial cystitis (HIC). In addition, maternally expressed gene 3 (MEG3) implicated many urethral diseases. this study, we aimed to verify hypothesis that exosomal MEG3 urine can be used as a novel diagnostic biomarker for HIC. Methods Electron microscopy was utilized observe distribution urinary exosomes between case group and control group. Receiver operating characteristic...
It has been reported that CD40 rs1883832 might be associated with immune-related diseases susceptibility. Owing to mixed and inconclusive results, we conducted a meta-analysis of case-control studies summarize clarify this association.A systematic search on the association between susceptibility was in databases. Odds ratios 95% confidence intervals were used pool effect size. 40 articles included our meta-analysis.CD40 is decreased risk Graves' disease, especially Asian; increased multiple...
The present study investigated the molecular mechanism of apoptosis and autophagy in prostate epithelial cells under androgen deprivation (AD). BPH-1 were divided into four groups as follows: Control (Cont), AD, inhibition (AI) AD + AI groups. Cells treated accordingly, level was subsequently measured via flow cytometry. expression microtubule-associated proteins 1A/1B light chain 3 (LC3), caspase-3, poly (ADP-ribose) polymerase 1 (PARP-1) Beclin-1 detected at different time points following...
Human Pygopus 2 (Pygo2) was recently discovered to be a component of the Wnt signaling pathway required for β-catenin/Tcf-mediated transcription. But role Pygo2 in malignant cell proliferation and invasion has not yet been determined.Lentivirus-mediated small interfering RNA (siRNA) vector-based overexpression were used study function OS-RC-2 cells. The resulted cells subject Western blotting assay, MTT colony formation assays. Furthermore, renal carcinoma (RCC) models established BALB/c...
This study aims to explore the effect of silencing Beclin-1 gene on autophagy and apoptosis Benign Prostatic Hyperplasia (BPH) (BPH-1) cells under condition Androgen Deprivation (AD) Autophagy Inhibition (AI). Control group (BPH-1 group), empty carrier (sh-RNA-BPH-1 group) silenced (sh-Beclin1-BPH-1 were set. The efficiency was detected by RT-PCR Western blot. Autophagic flux monitored GFP-LC3 cleavage assay cell analyzed flow cytometry. protein expression levels LC3, Caspase-3, PARP-1,...
To explore the associated proteins of hypothalamus in aging rat models with intervention by Qiongyugao(QYG) based on iTRAQ technology, find out target protein candidates and investigate mechanism delaying for Qiongyugao. The results showed that Qiongyugao increased GSH-Px activity serum SOD liver; total count identified was 3 522, FDR<1%. There were 20 kinds differential between blank group model group; there 295 QYG group, 40 them had a difference multiple ≥1.30 (the maximum value 1.47)....
This article has been retracted, and the online PDF watermarked ``RETRACTION''. The retraction notice is available at http://doi.org/10.3233/CBM239001.
This study aims to observe the changes and diagnostic values of urinary trace elements in patients with renal cell carcinoma (RCC).A total 28 RCC that had been performed radical surgery for more than 3 years were included into this case-control study; meanwhile, thirty healthy volunteers without kidney diseases set as control group over same period. The levels various both groups measured, results significance analysis pattern recognition using partial least square discriminant Fisher...
Objective The aim of this study was to evaluate the value serum exosomal miRNAs, originating from tumor tissue cells, could be used as noninvasive biomarker for distinguishing clear cell renal carcinoma (ccRCC). Methods 30 pairs samples and corresponding were collected 20 ccRCC male patients 10 female patients, operated in our department June 2015 2016. Their age ranged 45 70 years old, mean 57 old. Based on miRNA microarray analysis ccRCCs expression profiles, we picked up four...
Aim The aim of the present study was to assess application value B ‐mode ultrasound in percutaneous nephrolithotomy ( PCNL ). Methods and Patients performed 218 consecutive patients with upper urinary calculi using ultrasound. renal access established, residual stone detected by nephroscope through Results Phase I successfully established all patients. Operation time ranged from 40 min 132 min. nephrostomy tube retained 2–7 days. After treatment, 12 received blood transfusion because obvious...
Abstract The Au‐catalyzed intramolecular alkyne oxidation of 2‐ethynylanisoles (I) using quinoline N‐oxides as oxidants affords title compounds (II) in moderate to good yields.
Purpose To evaluated the effect of ureteral stent placement before flexible ureteroscopic lithotripsy(FURL). Methods A systematic search PubMed, Cochrane Library, Embase, Scopus, VIP, CNKI, Wanfang database from databases establishment to February 2017 was performed identify all clinical trials on stenting lithotripsy. The outcomes included stone-free rate, mean operative time, success rate access sheath and postoperative complications. RevMan 5.3 software used complete Meta...
First-principle density functional calculations have been carried out to explore the mechanism of BF 3 -catalyzed intramolecular coupling between a C ( sp )- H bond in α-position such heteroatom as O and an electron-deficient alkene that has electron-withdrawing substitute, e.g. acetal or carbonyl [McQuaid KM, Sames D, J Am Chem Soc131:402, 2009]. The computations not only confirmed previously proposed coordination (as Lewis acid catalyst) oxygen atom triggers 1,5-hydride transfer from α-...
Objective To invetigate The effect of Pygo2 to renal carcinoma cell OS-RC-2 apoptosis in vitro.Methods Lentiviral-mediated reorganization the three plasmids,to establish silence group,the overexpression group and corresponding control group.Lentiviral was used infect cells,and shRNA infection efficiency detected by realtime quantitative polymerase chain reaction (Real-time PCR).Propidium iodide (PI) staining detect detecting protein C-poly adenosine diphosphate-ribose (PARP) expression using...
Objective To discuss the clinical and pathological features of juvenile xanthogranuloma testis.Methods A case testis was reported.A 6-month-old boy presented with scrotal mass for 2 weeks before admission.Physical examination revealed that left hard size 2.0 cm×2.0 cm serum alpha-fetoprotein 37.60 μg/L.Chest X-ray human chorionic gonadotropin investigations were normal.B-ultrasound showed a solid uniform homogeneity in testis,with rich blood supply.Results The patient underwent operation...
Objective To study the expression of hepatocyte nuclear factor 4α(HNF4α)in renal cell carcinoma(RCC)and its value for diagnosis and prognosis RCC. Methods Real-time quantitative polymerase chain reaction(Real-time PCR) was used to detect level HNF4αm RNA in 30 cases paired neoplastic noncancerous parenchyma samples, HNF4αprotein tested by immunohistochemichal staining, difference HNF4αand relationship with RCC clinical stage other clinicopathologic features were investigated date...