A5100638186- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Renal and related cancers
- Renal cell carcinoma treatment
- Cancer, Hypoxia, and Metabolism
- Circular RNAs in diseases
- Cancer, Lipids, and Metabolism
- Biochemical Acid Research Studies
- Cancer Mechanisms and Therapy
- Cancer Genomics and Diagnostics
- Urinary Bladder and Prostate Research
- RNA Research and Splicing
- Urinary and Genital Oncology Studies
- Electrochemical sensors and biosensors
- Hippo pathway signaling and YAP/TAZ
- Alcoholism and Thiamine Deficiency
- Lipid metabolism and biosynthesis
- Advanced biosensing and bioanalysis techniques
- Bladder and Urothelial Cancer Treatments
- Nanoparticle-Based Drug Delivery
- Bacterial Identification and Susceptibility Testing
- Advanced Proteomics Techniques and Applications
- Chronic Kidney Disease and Diabetes
First Affiliated Hospital of Xiamen University
2008-2023
Fujian Medical University
2008-2020
University of Tübingen
2018
Huazhong University of Science and Technology
2010
MicroRNAs (miRNAs) are known to affect the occurrence and progression of cancer. We therefore evaluated involvement miR-223-3p in renal cell MiR-223-3p was highly expressed clear cancer tissues. Clear patients with higher expression had tumor stages grades poorer prognoses. In cells, overexpression enhanced proliferation metastasis, while inhibition reduced malignant capacity cells. found bind directly solute carrier family 4, member 4 (SLC4A4) mRNA, thereby reducing SLC4A4 mRNA protein...
BackgroundLipid accumulation has been highlighted in cancer development and progression, but the exact mechanism remains unclear renal cell carcinoma (RCC). MicroRNAs (miRNAs) have confirmed to participate pathological processes of cancers, including tumour occurrence inhibition. However, role miR-765 not elucidated clear (ccRCC).MethodsUsing The Cancer Genome Atlas (TCGA) database qRT-PCR, we investigated differences proteolipid protein 2 (PLP2) expression, as well their clinical relevance....
Clear cell renal carcinoma (ccRCC) is the highest mortality, invasion, and metastasis subtype of carcinoma. Bone morphogenetic protein (BMP) family has recently emerged as a group cancer-related proteins in multiple pathogenesis cancers. Currently, little known about prediction role BMPs ccRCC. Therefore, we screened The Cancer Genome Atlas Kidney Cell Carcinoma (TCGA-KIRC) database for ccRCC patients with complete clinical information BMP expression data. Multivariate analysis showed that...
Abstract: Minichromosome maintenance (MCM) proteins play an essential role in DNA replication. They have been shown to be overexpressed various types of cancer. However, the this family renal cell carcinoma (RCC) is widely unknown. In study, we identified a number RCC datasets Gene Expression Omnibus database and also investigated correlation between expression levels MCM genes clinicopathological parameters. We found that are positively correlated with one another. MCM2, MCM5, MCM6, MCM7,...
Abstract Hydroxy acid oxidase 2 (HAO2) has been reported to inhibit tumor progression through metabolic pathway. The current study was designed evaluate the prognostic significance and probable mechanism of HAO2 in patients with clear cell renal carcinoma (ccRCC). screened Cancer Genome Atlas Kidney Clear Cell Carcinoma (TCGA‐KIRC) database for ccRCC having complete clinical information expression. Low associated shorter overall survival (OS) disease‐free (DFS). Gene set enrichment analysis...
Tripartite motif containing (TRIM) family protein has been involved in multiple pathogenesis of cancers. TRIM2 is a member the family, and its role clear cell renal carcinoma (ccRCC) remains to be unclarifid. Here, we showed clinical value biological ccRCC.ROC curves analyzed clinicopathological parameters, Kaplan-Meier survival analysis determined correlation OS DFS time, multivariate demonstrated prognostic indicator overall disease-free ccRCC with expression The Cancer Genome Atlas Kidney...
Abstract Inflammation status are especially for tumor growth, and microRNAs (miRNAs) confirmed to participate in cancer occurrence progression. However, the role of miR‐483‐5p relation with inflammation have not been elucidated renal cell (RCC). In this study, we intended explore expression relationship clear (ccRCC). Using microarray qRT‐PCR (Quantitative Real‐time Polymerase Chain Reaction), investigated plasma ccRCC tissues. Then, analyzed correlation clinicopathological parameters ccRCC....
Clear cell renal carcinoma (ccRCC) has the highest rate of metastasis and invasion in RCC is third most common adult urinary malignancy. miRNA may serve a critical role human cancer development progression, been confirmed to play pivotal migration. Since miR‑935 had verified be an oncogene or tumor suppressor various cancers, was unclear.Real-time quantitative polymerase chain reaction (qRT-PCR) used verify miR-935 expression. CCK-8 assay, wound healing assay transwell were investigate...
Abstract Background Increased hypoxia‐inducible factor 2α (HIF2α) activation is a common event in clear cell renal carcinoma (ccRCC) progression. However, the function and underlying mechanism of HIF2α ccRCC remains uninvestigated. We conducted this study to access potential link between junction plakoglobin (JUP) ccRCC. Methods Affinity purification mass spectrometry (AP‐MS) screening, glutathione‐s‐transferase (GST) pull‐down co‐immunoprecipitation (Co‐IP) assays were performed detect...
We report here the preparation and analytical application of mimetic enzyme-loading magnetic silica nanotubes (MSNs), which were synthesized via alumina template membrane method. The integrate advantages superparamagnetic characteristics. Hemin (a peroxidase mimic) was selected as a model for enzyme assays to demonstrate applicability these MSNs in immobilization. immobilized hemin exhibited excellent catalytic activity reusability. Using catalyst, fluorometric measurement thiamine has been...
This article has been retracted, and the online PDF watermarked ``RETRACTION''. The retraction notice is available at http://doi.org/10.3233/CBM239001.
Abstract A novel, selective, and sensitive magnetic-mimetic enzyme fluorescence immunoassay method for antigen detection has been developed by taking advantage of a magnetic separation process the amplification feature hemin label. This is based on twice amplified signal. The signal first due to ultrasmall size high surface-to-volume ratio silica-coated magnetite nanoparticles, which enable nanoparticles carry much more antibodies. Second, mimetic (hemin) as labeling reagent catalyzes...
Adiponectin signaling plays a vital function in many biological processes health and diseases. Recent studies have shown that adiponectin contributed carcinogenesis of cholangiocarcinoma (CC), the second most common primary hepatic malignancy. The aim this study is to investigate role CC by using small molecular AdipoR agonist (2-(4-Benzoylphenoxy)-N-[1-(phenylmethyl)-4-piperidinyl]-acetamide) vitro vivo.
It has been well known that gender palys an important role in the development of tumors. Though bladder cancer mainly affects male population, female population shows a much worse prognosis, suggesting urgent need for further studies UCB. Radical cystectomy (RC) remains gold standard muscle-invasive (MIBC). Whether reproductive organs should be reserved MIBC patients controversial. suggested tumor T stage plays decision making regarding reservation. Meanwhile, patents' will also taken into...