A5101463859- Protein Tyrosine Phosphatases
- Galectins and Cancer Biology
- RNA modifications and cancer
- Kruppel-like factors research
- MicroRNA in disease regulation
- Cancer-related gene regulation
- PI3K/AKT/mTOR signaling in cancer
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Liver physiology and pathology
- Cancer Cells and Metastasis
- Additive Manufacturing Materials and Processes
- Epigenetics and DNA Methylation
- Alcohol Consumption and Health Effects
- Genomics, phytochemicals, and oxidative stress
- High Entropy Alloys Studies
- Eicosanoids and Hypertension Pharmacology
- Ubiquitin and proteasome pathways
- Circular RNAs in diseases
- Liver Disease Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Traditional Chinese Medicine Analysis
- Immune cells in cancer
- Lipid metabolism and disorders
- ATP Synthase and ATPases Research
Second Affiliated Hospital of Nanjing Medical University
2025
Xinjiang Medical University
2025
Harbin Medical University
2024-2025
Second Affiliated Hospital of Harbin Medical University
2024-2025
Beihua University
2025
First Affiliated Hospital of Henan University
2025
The First People's Hospital of Changde
2025
Central South University
2025
China Agricultural University
2025
Anhui Medical University
2014-2024
Background and Aims Endoplasmic reticulum (ER) stress is associated with liver inflammation hepatocellular carcinoma (HCC). However, how ER links HCC remains obscure. Mesencephalic astrocyte‐derived neurotrophic factor (MANF) an stress‐inducible secretion protein that inhibits by interacting the key subunit of nuclear kappa light chain enhancer activated B cells (NF‐κB) p65. We hypothesized MANF may play a role in linking HCC. Approach Results Here, we found mRNA levels were lower tissues...
Human Methyltransferase-like 16(METTL16) is an independent N6-methyladenosine (m6A) methyltransferase. Previous studies have proven METTL16 been linked with some types of cancers. However, comparative the relevance across diverse tumors remain sparse. We comprehensively investigated effect expression on tumor prognosis human malignancies by analyzing multiple cancer-related databases like Tumor Immune Estimation Resource (TIMER) and protein atlas (HPA). Bioinformatics data indicated that was...
Abstract Background Ethanol is a tumor promoter. Both epidemiological and experimental studies suggest that ethanol may enhance the metastasis of breast cancer cells. We have previously demonstrated increased migration/invasion cells expressing high levels ErbB2. Amplification ErbB2 found in 20-30% patients associated with poor prognosis. sought to identify agents can prevent or ameliorate ethanol-induced invasion Cyanidin-3-glucoside (C3G), an anthocyanin present many vegetables fruits,...
Hepatocellular carcinoma (HCC), the most common form of primary liver cancer, is third leading cause cancer-related death in human. Alcohol a known risk factor for HCC. However it still unclear whether and how alcohol enhances progression metastasis existing We first retrospectively investigated 52 HCC patients (24 alcohol-drinkers 28 non-drinkers), found positive correlation between consumption advanced Tumor-Node-Metastasis (TNM) stages, higher vessel invasion poorer prognosis. In vitro...
Both epidemiological and experimental studies suggest that excessive alcohol exposure increases the risk for breast cancer enhances metastasis/recurrence. We have previously demonstrated enhanced migration/invasion of cells overexpressing ErbB2/HER2 were more sensitive to exposure. However, underlying mechanisms remain unclear. This study was designed investigate alcohol-enhanced aggressiveness cancer. Cancer stem (CSCs) play a critical role in metastasis recurrence.We evaluated effect...
It is generally agreed that the human brain responsive to environmental influences, and male may be particularly sensitive early adversity. However, this largely based on retrospective studies of older children adolescents exposed extreme environments in childhood. Less understood about how normative variations parent–child interactions are associated with development infant typical settings. To address this, we used magnetic resonance imaging investigate relationship between observational...
Mesenchymal stem cells, suffering from diverse gene hits, undergoes malignant transformation and aberrant osteochondral differentiation. Src homology region 2- (SH2-) containing protein tyrosine phosphatase 2 (SHP2), a non-receptor phosphatase, regulates multicellular differentiation, proliferation, transformation. However, the role of SHP2 in MSC fate determination remains unclear. Here, we showed that MSCs bearing activating SHP2E76K mutation underwent into sarcoma stem-like cells (SSCs)....
Abstract Accumulating evidence has identified the profibrogenic properties of IL-17A in organ fibrosis. However, role signal liver fibrosis induced by Schistosoma japonicum infection remains unclear. In this study, we investigated wild-type (WT) and IL-17RA−/− mice upon S. infection. Hepatic IL-17A, IL-17C, IL-17E (IL-25), IL-17F, IL-17RA, IL-17RB IL-17RC transcript levels were determined RT-PCR. IL-17A+ cells analyzed flow cytometry confocal microscopy among granuloma cells. Immunostaining...
Significance Genetic mutations of protein tyrosine phosphatase nonreceptor type 11 Ptpn11 (Shp2) are associated with childhood leukemias and solid tumors. The mechanisms by which induce malignancies not fully understood. In this study, we demonstrate that disease disturb mitosis cytokinesis, causing chromosomal instability greatly increased susceptibility to DNA damage-induced malignancies. This finding reveals a novel mechanism deregulation Shp2 induces has important clinical implications....
Autism spectrum disorder (ASD) is a common neurodevelopmental condition, and infant siblings of children with ASD are at higher risk developing autistic traits or an diagnosis, when compared to those typically siblings. Reports differences in brain anatomy function high‐risk infants which predict later behaviors emerging, but although cerebellar subcortical regions have been frequently implicated ASD, no study has examined these regions. Therefore, this study, we regional MRI volumes across...
Epidemiological studies demonstrate that alcohol consumption is associated with an increased risk of colorectal cancer (CRC). In addition to promoting carcinogenesis, may also accelerate the progression existing CRC. We hypothesized enhance aggressiveness this study, we investigated effect on migration/invasion and metastasis Alcohol cells (DLD1, HCT116, HT29, SW480) in a concentration-dependent manner. Among these colon cell lines, HCT116 were most responsive while HT29 least...
Abstract Background MicroRNAs (miR, miRNAs) play pivotal roles in numerous physiological and pathophysiological contexts. We investigated whether miR-362-5p act as an oncogene chronic myeloid leukaemia (CML) aimed to understand its potential underlying mechanisms. Methods compared the expression levels between CML non-CML cell lines, fresh blood samples from patients normal healthy controls using quantitative real-time PCR (qPCR). Cell counting kit-8 (CCK-8) Annexin V-FITC/PI analyses were...
An increasing number of studies have indicated that the deregulation microRNAs (miRNAs) contributes to tumorigenesis and metastasis. In present study, significant upregulation miR-362-5p was identified in breast cancer MDA-MB-231 MCF7 cell lines compared with control CCD-1095Sk line. The inhibition demonstrated significantly inhibit proliferation, migration invasion human cells. addition, knockdown induced G1 arrest promoted apoptosis Mechanistic investigations confirmed tumor suppressor...
// Mei Xu 1 , Siying Wang 1, 2 Zhenhua Ren Jacqueline A. Frank Xiuwei H. Yang Zhuo Zhang 3 Zun-ji Ke 4 Xianglin Shi Jia Luo Department of Pharmacology and Nutritional Sciences, University Kentucky College Medicine, Lexington, KY 40536, USA Pathophysiological Department, School Basic Anhui Medical University, Hefei, 23002, China Toxicology Cancer Biology, Biochemistry, Shanghai Traditional Chinese 201203, Correspondence to: Luo, e-mail: jialuo888@uky.edu Keywords: alcohol abuse, cancer stem...
Honokiol is a bioactive lignanoid and has been utilized in traditional Chinese medicine for long time. It exhibits several pharmacological properties, such as anticancer effects, anti-inflammatory antianxiety effects. However, the poor aqueous solubility of honokiol impeded clinical applications.In present study, we adopted liquid antisolvent precipitation (LAP) technique to prepare nanoparticles enhancement bioavailability. Moreover, obtained were investigated evaluated terms morphology,...
Abstract The Helicobacter pylori (H. ) cytotoxin‐associated gene A (CagA) and Krüppel‐like transcription factor (KLF4) were both closely associated with the development progression of gastric cancer (GC). However, nature interactions between CagA KLF4 in GC has not been elucidated. Therefore, we focused on CagA‐mediated promotion malignant transformation epithelial cells. Herein, first examined expression human paracarcinoma tissues or without H. infection found that was significantly...