A5019069494- Advanced materials and composites
- Injection Molding Process and Properties
- Combustion and Detonation Processes
- Powder Metallurgy Techniques and Materials
- Titanium Alloys Microstructure and Properties
- Advanced ceramic materials synthesis
- Computational Fluid Dynamics and Aerodynamics
- RNA Research and Splicing
- Shape Memory Alloy Transformations
- Diamond and Carbon-based Materials Research
- Energetic Materials and Combustion
- Metal and Thin Film Mechanics
- Cancer, Hypoxia, and Metabolism
- Semiconductor Lasers and Optical Devices
- Intermetallics and Advanced Alloy Properties
- Orthopaedic implants and arthroplasty
- Advanced Welding Techniques Analysis
- Polymer Foaming and Composites
- Photonic and Optical Devices
- Structural Response to Dynamic Loads
- Aluminum Alloys Composites Properties
- Gas Dynamics and Kinetic Theory
- Aortic aneurysm repair treatments
- Aortic Disease and Treatment Approaches
- Angiogenesis and VEGF in Cancer
Guangxi University of Science and Technology
2017-2025
Sun Yat-sen University
2024-2025
Second Xiangya Hospital of Central South University
2009-2024
Central South University
2010-2024
University of Chinese Academy of Sciences
2011-2024
Chinese Academy of Sciences
2014-2024
Shanghai Institute of Organic Chemistry
2018-2024
Wuhan National Laboratory for Optoelectronics
2024
Huazhong University of Science and Technology
2020-2024
University of California, San Francisco
2020-2024
Background and Aims HSCs portal fibroblasts (PFs) are the major sources of collagen‐producing myofibroblasts during liver fibrosis, depending on different etiologies. However, mechanisms by which their dynamic gene expression directs transition from quiescent to activated state—as well as contributions fibrotic myofibroblasts—remain unclear. Here, we analyze activation PFs in CCL 4 ‐induced bile duct ligation–induced fibrosis mouse models, using single‐cell RNA sequencing lineage tracing....
The precise control of gene regulation, and hence, correct spatiotemporal tissue patterning, is crucial for plant development. Plant microRNAs can constrain the expression their target genes at posttranscriptional levels. Recently, microRNA396 (miR396) has been characterized to regulate leaf development by mediating cleavage its GROWTH-REGULATING FACTOR (GRF) targets. miR396 also preferentially expressed in flowers. However, function flower unclear. In addition narrow leaves, pistils with a...
Neoangiogenesis plays a key role in diverse pathophysiological conditions, including liver regeneration. Yet, the source of new endothelial cells (ECs) remains elusive. By analyzing regeneration vasculature irradiation-based myeloablative and nonmyeloablative bone marrow transplantation mouse models, we discovered that neoangiogenesis livers with intact endothelium was solely mediated by proliferation resident ECs. However, following irradiation-induced EC damage, marrow–derived mononuclear...
Abstract Mixed-lineage kinase domain-like protein (MLKL) is known as the terminal executor of necroptosis. However, its function outside necroptosis still not clear. Herein, we demonstrate that MLKL promotes vascular inflammation by regulating expression adhesion molecules ICAM1, VCAM1, and E-selectin in endothelial cells (EC). deficiency suppresses these molecules, thereby reducing EC-leukocyte interaction vitro vivo. Mechanistically, show interacts with RBM6 to promote mRNA stability...
Severe acute respiratory syndrome coronavirus-2 is still active in Wuhan, China, and spreading to the rest of world. Recently, perioperative anesthetic management patients with suspected or confirmed has been reported. However, little reported on undergoing aortic dissection repair severe infection. During outbreak authors' team completed 4 cases successfully The purpose present report summarize current knowledge experiences this patient population provide clinical practice guidelines...
Ferroelectric tunnel junction (FTJ) is considered one of the promising emerging non-volatile memories. In recent years, development freestanding ferroelectric has provided greater freedom for preparation and performance control FTJs. this work, we prepared a series PbTiO 3 ferroelectrics with different thicknesses successfully transferred them to Nb:SrTiO or Si substrates prepare devices. The structure was characterized by X-ray diffraction transmission electron microscopy, confirming high...
Disruption of endothelial cell (ECs) and pericytes interactions results in vascular leakage acute lung injury (ALI). However, molecular signals mediating EC–pericyte crosstalk have not been systemically investigated, whether targeting such could be adopted to combat ALI remains elusive. Using comparative genome-wide analysis healthy LPS-challenged lungs, we discovered that between nitric oxide pericyte soluble guanylate cyclase (NO–sGC) is impaired ALI. Indeed, stimulating the NO–sGC pathway...
Cells can respond and adapt to complex forms of environmental change. Budding yeast is widely used as a model system for these stress response studies. In studies, the precise control environment with high temporal resolution most important. However, there lack single-cell research platforms that enable temperature form cell growth. This has hindered our understanding cellular coping strategies in face diverse Here, we developed novel temperature-controlled microfluidic platform integrates...
A study was conducted to evaluate the effect of nano-silica (NS) content on strength and cytotoxicity calcium-silicate-based root canal filling materials. In this experimental laboratory study, four types paste with different NS ratios were prepared hydrated for seven or 28 days. The setting times, compressive strengths, porosities tested determine properties pastes. residual calcium hydroxide (CH; Ca (OH)2) investigated analyze hydration products. experiments demonstrated that facilitates...
ABSTRACT Two‐phase titanium alloy, pivotal in ultrasonic scalpels, exhibits working dynamics similar to fatigue behavior under axial vibration loading ( R = −1) exceeding 20 kHz, with its ultra‐high‐cycle (UHCF) performance being crucial for clinical applications. This study investigates the UHCF properties of Ti6Al4V alloy by evaluating microstructure variations and provides insights into mechanism nanograin formation expansion internal crack initiation sites. Key findings indicate that a...
In this study, the corrosion resistance of titanium nitride (TiN), nitrogen carbide (TiCN) and titanium-diamond-like carbon (Ti-DLC) films deposited on 316L stainless steel (SS) were compared via differences in surface section-cross morphologies, open circuit potential tests, electrochemical impedance spectroscopy potentiometric tests. The TiCN Ti-DLC significantly improved because (TiC) crystals that obstruct corrosive species penetrating as-deposited film electrolyte atmosphere. TiN...
Glia and neurons face different challenges in aging may engage mechanisms to maintain their morphology functionality. Here, we report that adult-onset downregulation of a Drosophila gene CG32529/GLAD led shortened lifespan age-dependent brain degeneration. This regulation exhibited cell type subtype-specificity, involving mainly surface glia (comprising the BBB) cortex (wrapping neuronal soma) flies. In accordance, pan-glial knockdown GLAD disrupted BBB integrity glial meshwork. expression...
Numerical simulations of imploding shock waves for detonation initiation are reported. We solve the one-dimensional Navier-Stokes equations and two-dimensional Euler chemically reactive flows by space-time conservation element solution method. One-dimensional results in cylindrical coordinates show that a converging produced breaking diaphragm an initial pressure ratio 1:0.2 atm is able to successfully initiate argon-diluted hydrogen/oxygen mixture (0.2H 2 + 0.1O 0.7Ar) initially at 300 K....