About
Contact & Profiles
A5000676122
Research Areas
- Angiogenesis and VEGF in Cancer
- Cancer, Hypoxia, and Metabolism
- Barrier Structure and Function Studies
Shanghai Institute of Organic Chemistry
2022
Chinese Academy of Sciences
2022
Disruption of endothelial cell (ECs) and pericytes interactions results in vascular leakage acute lung injury (ALI). However, molecular signals mediating EC–pericyte crosstalk have not been systemically investigated, whether targeting such could be adopted to combat ALI remains elusive. Using comparative genome-wide analysis healthy LPS-challenged lungs, we discovered that between nitric oxide pericyte soluble guanylate cyclase (NO–sGC) is impaired ALI. Indeed, stimulating the NO–sGC pathway...
10.1084/jem.20211422
article
EN
cc-by-nc-sa
The Journal of Experimental Medicine
2022-10-28
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