A5103040293- Cancer Cells and Metastasis
- Cancer, Hypoxia, and Metabolism
- Cancer, Stress, Anesthesia, and Immune Response
- FOXO transcription factor regulation
- Ferroptosis and cancer prognosis
- Gut microbiota and health
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Heterotopic Ossification and Related Conditions
- MicroRNA in disease regulation
- Cancer Immunotherapy and Biomarkers
- Mesenchymal stem cell research
- Alkaline Phosphatase Research Studies
- Mycobacterium research and diagnosis
- Bone fractures and treatments
- Protein Tyrosine Phosphatases
- Cancer-related molecular mechanisms research
Wuhan University
2024
Anhui Medical University
2023-2024
Mesenchymal stem cells, suffering from diverse gene hits, undergoes malignant transformation and aberrant osteochondral differentiation. Src homology region 2- (SH2-) containing protein tyrosine phosphatase 2 (SHP2), a non-receptor phosphatase, regulates multicellular differentiation, proliferation, transformation. However, the role of SHP2 in MSC fate determination remains unclear. Here, we showed that MSCs bearing activating SHP2E76K mutation underwent into sarcoma stem-like cells (SSCs)....
Heterotopic ossification (HO), often arising in response to traumatic challenges, results from the aberrant osteochondral differentiation of mesenchymal stem cells (MSCs). Nevertheless, impact trauma-induced inflammatory exposure on MSC fate determination remains ambiguous. In this study, cellular diversity within lesions is elucidated, comprising MSCs and several innate adaptive immune cells. It observed that quiescent transition into cycling MSCs, subsequently giving rise chondrogenic...
Hepatocellular carcinoma (HCC) is an aggressive and challenging disease to treat. Due the lack of effective early diagnosis therapy for illness, it crucial identify novel biomarkers that can predict tumor behavior in HCC. In such cases, family with sequence similarity 210 member B (FAM210B) abundant various human tissues, but its regulatory mechanisms role tissues remain unclear. this study, we analyzed expression pattern FAM210B HCC using public gene databases clinical tissue samples. Our...
The relationship between the gut microbiota and acute myeloid leukemia (AML) has been established, but exact role of interleukin (IL) in mediating this remained unclear. This study aimed to utilize whether interleukins mediate relationships AML, thereby identifying potential novel targets for future AML treatment. Mendelian randomization (MR) is a method finding causality exposure outcome. Final instrumental variables were selected based on MR assumptions, used judge validity results. Our...