A5100319288- Toxoplasma gondii Research Studies
- Cancer-related gene regulation
- RNA Research and Splicing
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Parasitic Infections and Diagnostics
- Autophagy in Disease and Therapy
- Technology Adoption and User Behaviour
- Cellular Mechanics and Interactions
- Cell Image Analysis Techniques
- Cytomegalovirus and herpesvirus research
- Circular RNAs in diseases
- Kruppel-like factors research
- Phagocytosis and Immune Regulation
- Herpesvirus Infections and Treatments
- Neurogenesis and neuroplasticity mechanisms
- MicroRNA in disease regulation
- Genomics and Chromatin Dynamics
- Chromosomal and Genetic Variations
- Cancer-related molecular mechanisms research
- RNA Interference and Gene Delivery
- Erythrocyte Function and Pathophysiology
- Curcumin's Biomedical Applications
- Toxin Mechanisms and Immunotoxins
- Optical Coherence Tomography Applications
Nanjing Drum Tower Hospital
2023-2025
Union Hospital
2023-2024
Huazhong University of Science and Technology
2023-2024
Nanjing University of Chinese Medicine
2024
Changchun Institute of Applied Chemistry
2024
Chinese Academy of Sciences
2024
Tianjin Medical University Cancer Institute and Hospital
2024
Anhui Medical University
2012-2023
Fourth Affiliated Hospital of Harbin Medical University
2023
Harbin Medical University
2016-2023
Abstract The reticulon family has been found to induce apoptosis, inhibit axon regeneration and regulate protein trafficking. However, little is known about the mechanisms of how proteins are involved in neuronal death-promoting processes during ischemia. Here, we report that expression Reticulon Protein 1-C (RTN1-C) was associated with progression cerebral ischemia/reperfusion (I/R) injury. Using a combination rat middle artery occlusion (MCAO) stroke oxygen-glucose deprivation followed by...
Abstract Acute severe autoimmune hepatitis (AS‐AIH) is characterized by rapid progression and poor prognosis, with a current lack of effective targeted treatments. Stem cell therapy has demonstrated significant therapeutic promise across various diseases. However, the intricate pathogenesis AS‐AIH hindered widespread utilization mesenchymal stem cells (MSCs) in this domain. Herein, it that necroptosis, as primary mode death AIH, crucial causing AS‐AIH. Inflammatory macrophages are population...
Autophagy is one of the underlying causes resistance to many antitumor drugs, including cisplatin (DDP). The low-density lipoprotein receptor (LDLR) a regulator ovarian cancer (OC) progression. However, whether LDLR regulates DDP in OC via autophagy-related pathways remains unclear. expression was measured by quantitative real-time PCR, western blot (WB) and IHC staining. A Cell Counting Kit 8 assay employed evaluate cell viability, flow cytometry used assess apoptosis. WB analysis proteins...
The existence of phenotypic differences in the drug responses 3D tissue relative to 2D cell culture is a concern high-content screening. Biodynamic imaging an emerging technology that probes using short-coherence dynamic light scattering measure intracellular motions inside tissues their natural microenvironments. information content biodynamic displayed through dynamics spectroscopy (TDS) but has not previously been correlated against morphological image analysis culture. In this article,...
Because advanced laryngeal squamous cell carcinoma (LSCC) is diagnosed as a malignant tumor with poor prognosis, the associated mechanisms still need to be further investigated. As key players in development and progression of LSCC, lncRNAs have attracted increasing attention from many researchers. In this study, novel lncRNA termed IGKJ2-MALLP2 was identified investigated for its effects on LSCC. expression confirmed by RT-qPCR 78 pairs tissues human lines. The results study showed that...
The results of hybrid quantum mechanical/molecular mechanical (QM/MM) free energy (potential mean force) simulations for methyl-transfer processes in SET7/9 and its Y245A mutant are compared to address the question concerning change product specificity as well catalytic efficiency due mutation. One key questions is whether or not profiles methyl transfers may be used predict a result mutations residues that located at Tyr/Phe switch position. show while wild-type monomethylase, Y245→A...
MicroRNAs (miRNAs) are reported to be important regulators of cancer-related processes, and function either as oncogenes or tumor-suppressor genes. It was found that miR-375 downregulated in samples laryngeal squamous cell carcinomas (LSCCs) compared the level noted adjacent non-tumor tissues, it inversely correlated with T grade, lymph node metastases clinical tumor stage. Overexpression led a decreased protein Krüppel-like factor 4 (KLF4) marked suppression proliferation invasion, induced...
N6‑methyladenosine (m6A) is the most abundant eukaryote mRNA modification, modulated by regulators known as epigenetic writers, erasers and readers, which are to serve crucial roles in metabolism. However, role of m6A during B‑cell development tumorigenesis remains poorly understood. By analyzing gene expression profile 123 mantle cell lymphoma cases from Gene Expression Omnibus database, present study demonstrated that one‑half were able predict patient survival lymphoma, notably m6A.index....
Histone deacetylases (HDACs) are well-characterized for their involvement in tumor progression. Herein, the current study set out to unravel association of HDAC8 with colorectal cancer (CRC). Bioinformatics analyses were carried retrieve expression patterns CRC and underlying mechanism. Following determination, specific roles HDAC8, IRF1, SUCNR1 cell functions analyzed following different interventions. Additionally, formation liver metastasis nude mice operated verify fore experiment....
Abstract Pyroptosis is an effective anti‐tumor strategy. However, monometallic pyroptosis biotuners have not been explored until now. Here, we discover for the first time that biodegradable Al can act as a biotuner tumor therapy. pH‐sensitive nanoparticles (Al@P) are obtained by equipping polyethylene glycol‐ b ‐(poly(methyl methacrylate)‐co‐poly(4‐vinylpyridine), which exert their effect at site without affecting normal cells. The H 2 and 3+ release Al@P in acidic environment of tumors...
Interferon-γ (IFN-γ)-activated macrophages restrain the replication of intracellular parasites and disrupt integrity vacuolar pathogens. The growth less virulent type II strain Toxoplasma gondii (such as ME49) was strongly inhibited by IFN-γ-activated murine macrophages. However, mechanism resistance is poorly understood. Immunity-related GTPases (IRGs) well guanylate-binding proteins (GBPs) contributed to this antiparasitic effect. Previous studies showed cassette autophagy-related...
As a major co-factor of F-actin depolymerization, WD-repeat domain 1 (WDR1) affects the cellular microenvironment by cytoskeleton remodeling, thereby influencing cell molecular behavior. Our previous study showed that WDR1 activates YAP (Yes-associated protein) signaling in non-small-cell lung cancer (NSCLC) cells, but mechanism remains unclear. We discovered knockdown NSCLC cells decreased expression and nucleus-to-cytoplasm ratio. Disruption cortical stress drugs significantly inhibited...
Rhododendron huadingense is an important horticultural plant that belongs to the Ericaceae family. In this study, chloroplast genome sequence of R. reported. The was 198,952 bp in length and had angiosperm-typical quadripartite structure with a large single-copy (LSC) region 108,557 bp, small (SSC) 53 two inverted repeat regions (IRs) 45,171 bp. One hundred thirteen unique genes including 79 protein-coding genes, 30 transfer RNA (tRNA) four ribosomal (rRNA) were identified genome. Further...
Chromatin insulators are responsible for orchestrating long-range interactions between enhancers and promoters throughout the genome align with boundaries of Topologically Associating Domains (TADs). Here, we demonstrate an association gypsy insulator proteins phosphorylated histone variant H2Av (γH2Av), normally a marker DNA double strand breaks. Gypsy components colocalize γH2Av genome, in polytene chromosomes diploid cells which IP data shows it is enriched at TAD boundaries. Mutation...
Toxoplasma gondii dense granule protein GRA3 has been shown to promote transmission and proliferation by interacting with the host cell endoplasmic reticulum (ER) through calcium-regulated cyclophilin ligands (CAMLG). Although many studies have focused on interaction between GRA3, no polyclonal antibodies (PcAbs) against reported date. According antigenicity prediction exposure site analysis, three antigen peptide sequences were selected prepare targeting GRA3. Peptide scans revealed that...
β‑Klotho (KLB) is a vital element of the fibroblast growth factor (FGF) receptor complex and acts as co‑receptor to facilitate binding FGF19 FGF21 FGFRs on target cells. The present study aimed determine contribution FGF21‑KLB signaling hepatocellular carcinoma (HCC) metastasis. KLB expression was measured in HCC tissues cell lines using western blot reverse transcription‑quantitative PCR. Furthermore, proliferation, apoptosis metastasis capacity KLB‑knockdown Huh7 cells (human line) were...
Benzene is a known contributor to human leukaemia through its toxic effects on bone marrow cells, and epigenetic modification believed be potential mechanism underlying benzene pathogenesis. However, the specific roles of N6-methyladenosine (m6A), newly discovered RNA post-transcriptional modification, in benzene-induced hematotoxicity remain unclear. In this study, we identified self-renewing malignant proliferating cells benzene-exposed mice vivo transplantation experiments Competitive...