A5024000222- Toxoplasma gondii Research Studies
- Cytomegalovirus and herpesvirus research
- Herpesvirus Infections and Treatments
- Parasitic Infections and Diagnostics
- Autophagy in Disease and Therapy
- interferon and immune responses
- Heme Oxygenase-1 and Carbon Monoxide
- Mosquito-borne diseases and control
- Phagocytosis and Immune Regulation
- Liver physiology and pathology
- Neuroinflammation and Neurodegeneration Mechanisms
- RNA Interference and Gene Delivery
- Bacterial Infections and Vaccines
- Macrophage Migration Inhibitory Factor
- Pancreatic and Hepatic Oncology Research
- Pneumonia and Respiratory Infections
- RNA regulation and disease
- Liver Disease Diagnosis and Treatment
- Endoplasmic Reticulum Stress and Disease
- Cardiac Ischemia and Reperfusion
- Bacteriophages and microbial interactions
- Cancer-related molecular mechanisms research
- Veterinary medicine and infectious diseases
- Histone Deacetylase Inhibitors Research
- Natural Compounds in Disease Treatment
Anhui Medical University
2015-2025
Hangzhou Center for Disease Control and Prevention
2019-2024
Dalian Medical University
2023
First Affiliated Hospital of Dalian Medical University
2023
First Affiliated Hospital of Bengbu Medical College
2021
Center for Disease Control
2021
Qilu Hospital of Shandong University
2021
First Affiliated Hospital of Anhui Medical University
2016-2021
Shandong First Medical University
2021
Zhejiang Center for Disease Control and Prevention
2021
Recent studies of Toxoplasma gondii isolates from animals in different regions China have shown a limited genetic diversity and type 1 was the dominant genotype T. prevalent Chinese animals. However, little has been known concerning isolation genotyping circulating chickens, pigs rodents China. The aim study to characterize samples obtained naturally infected cats, free-range chickens slaughtered for human consumption China.In present study, brain tissues 77 collected areas China, including...
Toxoplasma gondii (T. gondii) is a very successful parasite that can infect virtually all warm blooded animals with worldwide distribution. It causes large range of clinical manifestations in both humans and domesticated animals. In addition, marked biological differences exist among T. strains the pathogenicity geographical Molecular epidemiology studies primarily based on restriction fragment length polymorphism (RFLP) method revealed three main types are predominant North America Europe,...
A plethora of evidence shows that activated microglia play a critical role in the pathogenesis central nervous system (CNS). Toxoplasmic encephalitis (TE) frequently occurs HIV/AIDS patients. However, knowledge remains limited on contributions to TE. murine model reactivated was generated latent infection with Toxoplasma gondii induced by cyclophosphamide. The neuronal apoptosis CNS and profile pro-inflammatory cytokines were assayed both vitro vivo experiments. Microglial cells found be...
Abstract Macrophage therapy for liver fibrosis is on the cusp of meaningful clinical utility. Due to heterogeneities macrophages, it urgent develop safer macrophages with a more stable and defined phenotype treatment fibrosis. Herein, new macrophage‐based immunotherapy using stably expressing pivotal cytokine from Toxoplasma gondii , parasite that infects ≈ 2 billion people developed. It found macrophage migration inhibitory factor‐transgenic (Mφ tgmif ) shows fibrinolysis strong chemotactic...
Hepatic ischemia-reperfusion (I/R) injury can cause poor prognosis of liver transplantation and hepatectomy, especially in patients with alcohol-associated disease (ALD). Apoptosis is closely related to different stages injury, the death hepatocytes caused by endoplasmic reticulum (ER) mitochondria homeostasis perturbation may be key injury. The receptor tyrosine kinases AXL encoded gene axl, a member TAM (TYRO3, AXL, MERTK) family, which participates various biological processes binding...
Toxoplasmosis, a common parasitic disease, is caused by Toxoplasma gondii, which infects approximately 30% of the world's population. This obligate intracellular protozoan causes significant economic losses and poses serious public health challenges worldwide. However, development an effective toxoplasmosis vaccine in humans remains challenge to date. In this study, we observed that knockout calcium-dependent protein kinase 3 (CDPK3) type II ME49 strain greatly attenuated virulence mice...
Significance As a neurotropic parasite, Toxoplasma predominantly interacts with neurons throughout CNS infection and causes severe damage to the brain. In patients immune dysfunction, dormant encysted bradyzoites can reactivate into fast-replicating tachyzoites may cause We report that an endoplasmic reticulum (ER)-associated protein, RTN1-C, is substrate of ROP18 kinase. phosphorylation RTN1-C triggers ER stress-mediated apoptosis. Phosphorylated enhances GRP78 acetylation via attenuating...
Toxoplasma gondii, an obligate intracellular pathogen, has a strong affinity for the nervous system. TgCtwh3, representative Chinese 1 strain prevalent in China, polymorphic features of effectors ROP16I/III with type I and GRA15II II strains. The interaction this atypical host cells remains extremely elusive.Using transwell system, neural stem C17.2 were co-cultured tachyzoites TgCtwh3 or standard RH strain. apoptosis levels expression related proteins endoplasmic reticulum stress...
The neurotropic parasite T. gondii is widespread among mammalian hosts including humans. During the course of infection, central nervous system most commonly damaged all invasive organs. polymorphic rhoptry protein ROP18 has been identified as a key factor in pathogenesis gondii; however, molecular mechanism by which this exerts neuropathogenesis remains elusive. Immunofluorescence staining was performed to detect mouse brain tissues. apoptosis neural cells and expressions related proteins...
Toxoplasma gondii, a single-celled parasite commonly found in mammals, has been shown to induce trophoblast cell apoptosis and subsequently cause fetal damage abortion. Although dense granule protein 15 (GRA15) identified as key component innate immunity T. gondii infection its pathogenesis, role host remains unclarified. Type II GRA15 (GRA15II) cDNA was inserted into plasmid encoding enhanced green fluorescent (pEGFP). Choriocarcinoma JEG-3 cells were transfected with either pEGFP or...
Different from three clonal lineages of Toxoplasma gondii in North America and Europe, the genotype China 1 is predominantly prevalent China. However, there are different virulent isolates within 1, such as TgCtwh3 avirulent TgCtwh6, little known about differences macrophage activation between them. The objective this study focused on cytokine production, phenotype markers activated macrophages, correlated signaling pathway induced by two isolates. Adherent peritoneal macrophages (termed...
Toxoplasma gondii infection evokes a strong Th1-type response with IL-12 and IFN-γ secretion. Recent studies suggest that the of pregnant mice T. may lead to adverse pregnancy results caused by subversion physiological immune tolerance at maternofetal interface rather than direct invasion parasite. Genotype-associated dense granule protein GRA15 II tends induce classically activated macrophage (M1) differentiation subsequently activating NK, Th1 Th17 cells whereas rhoptry ROP16I/III drives...
Abstract Background Toxoplasma gondii is a neurotropic single-celled parasite that can infect mammals, including humans. Central nervous system infection with T. lead to encephalitis. cause endoplasmic reticulum (ER) stress and unfolded protein response (UPR) activation, which ultimately apoptosis of host cells. The dense granule GRA3 has been identified as one the secretory proteins contribute virulence ; however, mechanism remains enigmatic. Methods expression gene in RH, ME49, Wh3, Wh6...
Congenital infection of Toxoplasma gondii is an important factor causing birth defects. The neural stem cells (NSCs) are found to be one the target for parasite during development brain. As a key virulence that hijacks host cellular functions, ROP18 has been demonstrated mediate inhibition innate and adaptive immune responses through specific binding different immunity related molecules. However, its pathogenic actions in NSCs remain elusive.In present study, recombinant adenovirus...
Toxoplasma gondii can infect almost all endotherm organisms including humans and cause life-threatening toxoplasmosis in immunocompromised individuals, which leads to serious public health problems. Developing an excellent vaccine against this disease is impending. In present study, we formulated a cocktail protein the TgMIF, TgCDPK3, Tg14-3-3 proteins, play critical roles T. infection. The recombinant vaccines were constructed assessed by vaccination BALB/c mice. We organized mice various...
Hepatic ischemia/reperfusion (I/R) injury is a major cause of complications in clinical liver surgery. AXL receptor tyrosine kinase (AXL) member the TAM family (TYRO3, AXL, and MERTK). Our previous study has shown that expression was markedly upregulated transplantation patients. However, underlying mechanism hepatic I/R remains unclear.
Objectives: This study aimed to evaluate the safety profile of recombinant zoster vaccine (RZV) after its marketing in China. Methods: We present a descriptive analysis and signal assessment adverse events following immunization (AEFI) associated with RZV between September 2020 December 2023. The data collected includes demographic characteristics classification AEFI cases, while was evaluated using reporting odds ratio (ROR). Results: In total, we documented 275 cases vaccination, rate...