A5074623897- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Pneumonia and Respiratory Infections
- Vaccine Coverage and Hesitancy
- Influenza Virus Research Studies
- Genetic Associations and Epidemiology
- Lung Cancer Diagnosis and Treatment
- Bacterial Infections and Vaccines
- SARS-CoV-2 and COVID-19 Research
- Virology and Viral Diseases
- Radiomics and Machine Learning in Medical Imaging
- Respiratory viral infections research
- Viral gastroenteritis research and epidemiology
- Viral Infections and Immunology Research
- Herpesvirus Infections and Treatments
- Diphtheria, Corynebacterium, and Tetanus
- Hepatitis B Virus Studies
- Ferroptosis and cancer prognosis
- Hepatitis Viruses Studies and Epidemiology
- Cancer-related molecular mechanisms research
- Cancer, Lipids, and Metabolism
- Bayesian Methods and Mixture Models
- Heparin-Induced Thrombocytopenia and Thrombosis
- Syphilis Diagnosis and Treatment
West China Hospital of Sichuan University
2016-2025
Sichuan University
2016-2025
Hangzhou Center for Disease Control and Prevention
2015-2025
China Medical University
2024
Zhejiang Center for Disease Control and Prevention
2017-2024
Zhejiang University
2012-2024
Zhejiang University of Science and Technology
2024
Zhejiang Chinese Medical University
2024
University of Hong Kong
2020-2023
Shanghai Ocean University
2023
Abstract Purpose: We assessed whether perioperative circulating tumor DNA (ctDNA) could be a biomarker for early detection of molecular residual disease (MRD) and prediction postoperative relapse in resected non–small cell lung cancer (NSCLC). Experimental Design: Based on our prospective, multicenter cohort dynamic monitoring ctDNA surgery patients (LUNGCA), we enrolled 950 plasma samples obtained at three time points (before surgery, 3 days 1 month after surgery) 330 stage I–III NSCLC...
Abstract Metabolic syndrome (MetS), a cluster of metabolic disturbances that increase the risk for cardiovascular disease and diabetes, was because genetic susceptibility environmental factors. To identify variants associated with MetS components, we conducted genome‐wide association study followed by replications in totally 12,720 participants from north, north‐eastern eastern China. In combined analyses, independent top known signal at rs651821 on APOA 5, newly identified secondary...
Abstract Background Previous studies indicated that type 2 diabetes mellitus (T2DM) might be associated with the risk of cancer. The aim this study was to investigate association between T2DM and developing common cancers in a Chinese population. Methods A population-based retrospective cohort carried out Nan-Hu district Jiaxing city, Zhejiang province, China. incidence cancer cases among diabetic patients were identified through record-linkage Diabetic Surveillance Registry Database Cancer...
WHO had warned of the impending "X disease," emphasizing need to quickly establish an immune barrier. The willingness vaccination staff recommend vaccines was crucial in such scenarios. This study aimed investigate and influencing factors Non-EPI Vaccines recommendations among Chinese Hangzhou, China. We selected 191 clinics from Hangzhou for a questionnaire-based survey using cross-sectional survey. Descriptive statistics were made on characteristics participants. Univariate multivariable...
Abstract Background Circulating tumor DNA (ctDNA) is valuable for detecting minimal residual disease (MRD). However, studies involving long-term blood sampling are required to comprehensively interpret the clinical use of ctDNA analyses. Methods We conducted a prospective multicenter cohort study (LUNGCA) dynamic monitoring in lung cancer patients receiving curative-intent surgery. analysis was on preoperative plasma samples, at postoperative three days and one month, then every three–six...
Tyrosine kinase inhibitor (TKI) treatment has significantly improved the prognosis of oncogenic-driven lung adenocarcinoma (LUAD). However, drug resistance limits long-term benefits patients. Therefore, there is a pressing need to explore mechanism TKI and identify new therapeutic targets. It possible overcome by inducing tumor cell death through process called ferroptosis. Aberrations in ferroptosis, which kind regulated (RCD), been confirmed be involved development progression multiple...
The association of the rs9939609 single nucleotide polymorphism in FTO gene with obesity has been extensively investigated studies populations European, African, and Asian ancestry. However, inconsistent results have reported populations, relationship variation dietary behaviors only rarely examined Chinese children adolescents. aim this study was to assess preferences childhood a population. Epidemiological data including were collected interviews using survey questionnaires, genotype...
Chemotherapy is a commonly utilized treatment strategy for colon cancer, prevalent malignancy. The study intends to probe the function and mechanism of protocadherin 7 (PCDH7) in cancer. Gain or loss functional assays PCDH7 was performed. MTT colony formation assay monitored cell proliferation. Transwell measured migration invasion. Real-time quantitative polymerase chain reaction western blot verified profiles MEK1/2/ERK/c-FOS pathway. Western implemented confirm PP1α, MLC2, p-MLC2...
Abstract: Pityriasis rosea (PR) is a common inflammatory, erythematous and scaly skin condition that usually affects individuals aged from 20 to 40 years old. The disease often exhibits self-limiting course up 6– 8 weeks. We report 25-year-old female patient with six-month history of red rashes on the trunk proximal limbs, accompanied by severe pruritus has been remained ineffective conventional treatments. She was diagnosed as persistent pityriasis rosea. As abrocitinib proved be effective...
Copy number variants (CNVs) have been implicated as an important genetic marker of obesity, and gene-environment interaction has found to modulate risk obesity. To evaluate the associations between CNVs childhood well interactions dietary behaviors, we recruited 534 obese children 508 controls from six cities in China candidate were screened through published genome-wide studies (GWAS) on We three loci (10q11.22, 4q25 11q11) be significantly associated with obesity after false discovery rate...
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The purpose of this study was to examine the associations between genetic variations in Protocadherin 15 gene (PCDH15) and risk noise induced hearing loss (NIHL) a Chinese population.A case-control conducted with 476 noise-sensitive workers 475 noise-resistant (normal) matched for gender, years exposure, intensity exposure. 13 tag single-nucleotide polymorphisms PCDH15 were genotyped using nanofluidic dynamic arrays on Fluidigm platform. Multiple logistic regression used analyze NIHL...
To investigate the coverage of 23-valent pneumococcal polysaccharide vaccine (23-PPV) in Chinese urban elderly population and to understand attitudes, knowledge beliefs this toward 23-PPV vaccination.A cross-sectional approach was employed survey willingness receive vaccination. Two thousand 9 hundred 2 six subjects over age 60 y were enrolled via a multi-stage random sampling method from community Hangzhou, China. The relationships between variables vaccination computed as odds ratios (ORs)...
Malignant tumors in children are one of the most important diseases that threaten health and quality life second common cause death children.With continuous improvement progress treatment technology, long-term survival rate with tumor has been significantly improved, but both disease itself can impair immune function children, which makes them vulnerable to various infectious secondary serious complications, even become a source infection, endangering others. Vaccination is cost-effective...
The "reemergence of pertussis" has elicited international concerns, occurring paradoxically amidst the expansion immunization programs. This study was aimed to evaluate quantitatively economic burden and identify determinants that influence cost associated with treating pertussis in Chinese children. We evaluated by children diagnosed at Children's Hospital, Zhejiang University School Medicine 2022. Direct medical expenses utilization resources attributed were calculated. A generalized...
With the widespread use of 13-valent pneumonia vaccine (PCV13) in China, monitoring adverse events following immunization (AEFIs) is critical. We conducted a descriptive analysis AEFI occurrences reported within Hangzhou between years 2020 and 2023, including temporal trend case reports variables such as sex, age, type PCV13, dose number, reporter, cause-specific classification, severity, onset from vaccination. Vaccine safety signals were analyzed using reporting odds ratios (RORs). Over 4...
Non-small cell lung cancer (NSCLC) with malignant pleural disease (MPD) was considered to be contraindication for surgery, but sometimes MPD unexpectedly found intraoperatively. There no consensus on the role of surgical intervention primary tumor in patients MPD. The object this research assess whether exairesis could prolong survival time.A systemic literature performed databases PubMed, Embase and Web Science. Literatures examining benefit or other prognostic factors among NSCLC during...
Background: 23-valent pneumococcal polysaccharide vaccine (PPSV23) has been used to prevent disease, and PPSV23 became available in 2003 Hangzhou, China as a private-sector, vaccinee-chosen vaccine. No national guidelines for have developed. We analyzed coverage utilization Hangzhou determine patterns of use the occurrence adverse events following immunization (AEFI) Hangzhou.Materials Methods: Individuals over 2 years age were included. Vaccination data during 2006–2017 was retrieved from...
To evaluate the associations between candidate FTO single nucleotide polymorphisms (SNPs) and obesity, a case-control study was conducted among Chinese school-age children, which included 500 obese cases matched controls (age, gender location). We selected 24 tag-SNPs via bio-informatics analysis performed genotyping using SNPScan technology. Results indicated that rs7206790 rs11644943 were significantly associated with obesity children in both additive recessive models (P<0.05) after...
The study aims to develop a novel multistep chromatographic purification process for human enterovirus71 virus-like particles (VLPs) produced from insect cells (Sf9) infected with recombinant baculovirus.Sf9 were maintained in the Wave Bioreactor system 20/50, and harvested when viability decreased 75% after Bac-P1-3CD at multiplicity of infection (MOI) 1. After sonication centrifugation, EV71 VLPs purified Capto(™) Core 700, adhere butyl. purity was then determined by SDS-PAGE, Western...
Objective To delineate seroepidemiology of VZV in children aged 1-14 years Hangzhou, to evaluate immunological response VarV via 2 dose regimen immunization VarV, for improving strategy VarV. Methods From 2014-2016, a multi-stage stratified random sampling method was employed select participants included physical examination the Community Health Centre Hangzhou. Results were compared among 11 various age groups: 1-,2-,3-,4-,5-,6-,7-,8-,9-,10-,11-14 years. Demographic data and vaccination...
Background The DTaP-Hib and DTaP-IPV/Hib combination vaccine can be used as a substitute for the diphtheria, tetanus, acellular pertussis combined (DTaP). We aimed to evaluate safety of multi-component vaccines containing DTaP by analyzing reporting rates characteristics adverse events following immunization (AEFIs) in Linping District during years 2019 2022. Methods obtained data AEFI vaccination from National Surveillance System China Zhejiang Municipal Immunization Information Management...