A5018221573- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Lung Cancer Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Microscopic Colitis
- Terahertz technology and applications
- Radiomics and Machine Learning in Medical Imaging
- Systemic Lupus Erythematosus Research
- Trace Elements in Health
- Aortic Disease and Treatment Approaches
- Quinazolinone synthesis and applications
- Allergic Rhinitis and Sensitization
- Millimeter-Wave Propagation and Modeling
- Mycobacterium research and diagnosis
- Pregnancy and Medication Impact
- Microwave Engineering and Waveguides
- Gut microbiota and health
- Cardiac Arrest and Resuscitation
- Heavy Metal Exposure and Toxicity
- Occupational and environmental lung diseases
- Effects of Radiation Exposure
- Photosynthetic Processes and Mechanisms
- RNA Interference and Gene Delivery
- MicroRNA in disease regulation
West China Hospital of Sichuan University
2019-2025
Sichuan University
2019-2025
Shenyang Pharmaceutical University
2024
Tianjin University of Traditional Chinese Medicine
2024
Anhui Provincial Hospital
2024
Anhui Medical University
2022-2024
Inner Mongolia Medical University
2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2022
Peking Union Medical College Hospital
2017-2022
Chinese University of Hong Kong
2019-2021
Abstract Purpose: We assessed whether perioperative circulating tumor DNA (ctDNA) could be a biomarker for early detection of molecular residual disease (MRD) and prediction postoperative relapse in resected non–small cell lung cancer (NSCLC). Experimental Design: Based on our prospective, multicenter cohort dynamic monitoring ctDNA surgery patients (LUNGCA), we enrolled 950 plasma samples obtained at three time points (before surgery, 3 days 1 month after surgery) 330 stage I–III NSCLC...
Metamaterial (MM) assisted terahertz (THz) label-free biosensing has promising applications. However, the sensitive THz detection of highly absorptive liquid samples remains challenging. Here, we present a novel multi-microfluidic-channel MM biosensor for sensing small-volume samples. The multichannels are set mostly in strong electric field enhancement area MM, which significantly decreases liquid's amount and enhances interaction between targets wave (thus increasing sensitivity). results...
The epidermal growth factor receptor (EGFR) plays an important role in the proliferation of various cancers, and expression level EGFR tumor tissues can provide a basis for diagnosis prognosis. Improving detection technology to achieve high sensitivity faster speed will benefit many types tumors. Trace biological samples be sensitively measured with terahertz (THz) metamaterial devices. Here, bow-tie array THz biosensor is presented modified gold nanoparticles (GNPs) antibodies specific...
To investigate the changes in cortical thickness of region interest (ROI) and plasma Aβ40, Aβ42, phosphorylated Tau (P-Tau) concentrations patients with Alzheimer's disease (AD) amnestic mild cognitive impairment (aMCI) as progressed surface-based morphometry (SBM), to analyze correlation between ROI measured indexes neuropsychological scales, explore clinical value combined P-Tau early recognition diagnosis AD.This study enrolled 33 AD, 48 aMCI, healthy controls (normal control, NC)....
Abstract Background Circulating tumor DNA (ctDNA) is valuable for detecting minimal residual disease (MRD). However, studies involving long-term blood sampling are required to comprehensively interpret the clinical use of ctDNA analyses. Methods We conducted a prospective multicenter cohort study (LUNGCA) dynamic monitoring in lung cancer patients receiving curative-intent surgery. analysis was on preoperative plasma samples, at postoperative three days and one month, then every three–six...
Folic acid-conjugated temozolomide (TMZ)-loaded chitosan nanoparticles (CS-TMZ-FLA-NP) were developed to target lung cancer in the anticipation that folic acid would increase affinity of for cells. CS-TMZ-FLA-NP showed highest anti-proliferative effect on cells comparison free TMZ and CS-TMZ-NP (nanoparticles without acid). A cellular uptake assay was performed two different cell lines, L132 A549. Cellular efficiencies found be concentration-dependent both lines. produced a 2.5 fold greater...
Small extracellular vesicles (sEVs) carry molecular information from their source cells and are desired biomarkers for cancer diagnosis. We establish a machine learning-assisted dual-marker detection method to analyze the expression of epidermal growth factor receptor (EGFR) C-X-C chemokine 4 (CXCR4) in serum sEVs diagnosis prognosis prediction non-small cell lung (NSCLC). find that sEV EGFR CXCR4 significantly higher advanced stage NSCLC (A/NSCLC) patients compared early (E/NSCLC) healthy...
Objective Gut fungi, as symbiosis with the human gastrointestinal tract, may regulate physiology via multiple interactions host cells. The plausible role of fungi in systemic lupus erythematosus (SLE) is far from clear and need to be explored. Methods A total 64 subjects were recruited, including SLE, rheumatoid arthritis (RA), undifferentiated connective tissue diseases (UCTDs) patients healthy controls (HCs). Fecal samples collected. bacteria detected by ITS sequencing 16S rRNA gene...
Abstract Localization of multiple small pulmonary nodules is the major obstacle in surgical resection. Here, we report a novel noninvasive localization technique based on life‐size 3D printed “emulation nodule model” which simple and efficient. In case reported here patient with synchronous nodules, were successfully conveniently localized without any trauma by navigation emulation model. All 12 resected precisely thoroughly, while normal lung tissues considerably well preserved....
Supplementary Data from Perioperative ctDNA-Based Molecular Residual Disease Detection for Non–Small Cell Lung Cancer: A Prospective Multicenter Cohort Study (LUNGCA-1)
Objectives To investigate the causal relationships between pneumoconiosis and rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), gout. Methods The random-effects inverse variance weighted (IVW) approach was utilized to explore effects of instrumental variables (IVs). Sensitivity analyses using MR-Egger median (WM) methods were did horizontal pleiotropy. A leave-one-out analysis used avoid bias resulting from single-nucleotide polymorphisms (SNPs). Results There no association...
Despite the widespread adoption of video-assisted thoracoscopic surgery (VATS) for major lung resection, 10-year long-term survival outcomes non-small cell cancer (NSCLC) treated with VATS compared open resection is lacking. The purpose this study was to analyze short- and
Background: Atopic dermatitis (AD) is among the most frequently encountered skin diseases, bothering a considerable number of patients. Today, corticosteroids and antihistamines are numerous drugs applied for therapy AD. However, lengthy use them contributes to side effects, such as physiological changes in skin. As an alternative supplementary therapy, traditional Chinese medicine has become trend AD treatment. Huang-Lian-Jie-Du decoction (HLJDD), renowned herbal formula been employed treat...
Objective: To explore the accuracy and efficiency of a novel 3D-printed emulation localization model small pulmonary nodules in lung surgery. Methods: From April 2020 to 2021, total 66 patients were selected study, who underwent resection with video-assisted thoracoscopic surgery (VATS) guided by at Department Thoracic Surgery, West China Hospital Sichuan University. There 13 males 53 females, aged from 25 79 (52.7±11.4) years. Of all patients, 24 (36.4%) had single nodule, 42 (63.6%)...
Supplementary Data from Perioperative ctDNA-Based Molecular Residual Disease Detection for Non–Small Cell Lung Cancer: A Prospective Multicenter Cohort Study (LUNGCA-1)
Supplementary Data from Perioperative ctDNA-Based Molecular Residual Disease Detection for Non–Small Cell Lung Cancer: A Prospective Multicenter Cohort Study (LUNGCA-1)