A5103113144- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Pleural and Pulmonary Diseases
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Tracheal and airway disorders
- Salivary Gland Tumors Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Congenital Diaphragmatic Hernia Studies
- Radiomics and Machine Learning in Medical Imaging
- Cancer Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Esophageal and GI Pathology
- Vascular Procedures and Complications
- Cancer Cells and Metastasis
- Surgical site infection prevention
- Trauma Management and Diagnosis
- Cancer Immunotherapy and Biomarkers
- Voice and Speech Disorders
- Surgical Simulation and Training
- Lung Cancer Research Studies
- Medical Imaging and Pathology Studies
- Venous Thromboembolism Diagnosis and Management
- Bone Tumor Diagnosis and Treatments
Sichuan University
2015-2025
West China Hospital of Sichuan University
2015-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2025
University of Electronic Science and Technology of China
2025
Beijing Anzhen Hospital
2024
Capital Medical University
2024
State Key Laboratory of Biotherapy
2021
Science and Technology Department of Sichuan Province
2020
South China Institute of Collaborative Innovation
2016-2019
Abstract Purpose: We assessed whether perioperative circulating tumor DNA (ctDNA) could be a biomarker for early detection of molecular residual disease (MRD) and prediction postoperative relapse in resected non–small cell lung cancer (NSCLC). Experimental Design: Based on our prospective, multicenter cohort dynamic monitoring ctDNA surgery patients (LUNGCA), we enrolled 950 plasma samples obtained at three time points (before surgery, 3 days 1 month after surgery) 330 stage I–III NSCLC...
It is important to develop a surgical technique reduce dissemination of tumor cells into the blood during surgery.To compare outcomes different sequences vessel ligation surgery on and survival in patients with non-small cell lung cancer.This multicenter, randomized clinical trial was conducted from December 2016 March 2018 cancer who received thoracoscopic lobectomy West China Hospital, Daping Sichuan Cancer Hospital. To further 2 procedures, we reviewed Western Lung database (2005-2017)...
Radiotherapy remains one of the major treatments for non-small cell lung cancer (NSCLC) patients; whereas intrinsic or acquired radioresistance limits its efficacy. Nevertheless, most studies so far have only focused on resistance. The exact mechanisms in NSCLC are still unclear. A few suggested that epithelial-mesenchymal transition (EMT) is associated with NSCLC. However, little known about whether abnormal expression specific microRNAs induces both EMT and radioresistance. We previously...
Video-assisted thoracic surgery (VATS) has been considered as the better choice for surgical treatment of resectable non-small cell lung cancer (NSCLC). This study aimed to evaluate short- and long-term outcomes VATS versus open thoracotomy lobectomy patients with pathological stage (p-stage) I-II NSCLC in one high-volume center China.Perioperative survival who underwent lobectomies p-stage from May 2006 June 2013 Western China Lung Cancer Database (WCLCD) were studied using propensity score...
Massive bleeding caused by vascular injury is considered the most troublesome and dangerous complication during video-assisted thoracoscopic surgery (VATS) pulmonary resection an important reason for emergency conversion to thoracotomy. The purpose of this paper was show suction-compressing angiorrhaphy technique (SCAT) troubleshooting problem without conversion.A total 414 consecutive VATS anatomic resections were performed between May 2006 July 2011, among which 17 operations (4.11 %)...
<h2>Abstract</h2><h3>Objective</h3> Thoracoscopic anatomic single or combined basal segmentectomy is technically challenging because of the variation and deep location vessels bronchi in parenchyma. This study aimed to describe thoracoscopic segments using a single-direction method. <h3>Methods</h3> retrospective included 137 patients who underwent between April 2015 August 2019. All procedures were performed via preferred inferior pulmonary ligament approach an interlobar fissure following...
<h2>Summary</h2> Lung adenocarcinoma is a type of cancer that exhibits wide range clinical radiological manifestations, from ground-glass opacity (GGO) to pure solid nodules, which vary greatly in terms their biological characteristics. Our current understanding this heterogeneity limited. To address gap, we analyze 58 lung patients via machine learning, single-cell RNA sequencing (scRNA-seq), and whole-exome sequencing, identify six multicellular ecotypes (LMEs) correlating with distinct...
Tumor vaccines that activate the autologous immune system to eliminate tumor cells represent a promising approach in cancer immunotherapy. However, challenges such as heterogeneity, limited antigen selection, insufficient presentation, and slow onset of de novo responses have resulted poor universality suboptimal response rates. In contrast, pathogen-specific pre-existing immunity acquired through infection or vaccination, can rapidly generate more potent enduring upon re-encounter with same...
Abstract Background Circulating tumor DNA (ctDNA) is valuable for detecting minimal residual disease (MRD). However, studies involving long-term blood sampling are required to comprehensively interpret the clinical use of ctDNA analyses. Methods We conducted a prospective multicenter cohort study (LUNGCA) dynamic monitoring in lung cancer patients receiving curative-intent surgery. analysis was on preoperative plasma samples, at postoperative three days and one month, then every three–six...
With an increasing amount of small nodules being detected, segmentectomy has recently received a great deal attention. We have previously reported the feasibility and safety uniportal segmentectomy. This study aims to further compare perioperative oncological outcomes three-port thoracoscopic in lung cancer patients.Patients undergoing for from January 2014 March 2021 were enrolled. Clinical data collected Western China Lung Cancer Database, prospectively maintained database at Department...
This study aims to introduce an optimized method named “non-grasping en bloc mediastinal lymph node dissection (MLND)” through video-assisted thoracoscopic surgery (VATS). Between February 2009 and July 2013, 402 patients with clinical stage I non-small cell lung cancer (NSCLC) underwent MLND” conducted by one surgical team. Target nodes (LNs) were exposed following non-grasping strategy simple combination of a metal endoscopic suction electrocoagulation hook or ultrasound scalpel. In...
Background: Whether wedge resection is oncological suitable for ground glass opacity (GGO)-dominant non-small cell lung cancer (NSCLC) ≤2 cm still debatable. The aim of this study to investigate the short-term and long-term outcomes intentional segmentectomy those patients. Materials Methods: This was a real-world from one largest thoracic surgery centers in XX. Patients who underwent or CTR(consolidation-to-tumor)≤0.5 NSCLC were consecutively included between December 2009 2018. Data...
Background: The lack of anatomic landmarks between segments on the lung surface makes identification intersegmental planes one greatest challenges in segmentectomy. Therefore, with aim to determine surface, we used three-dimensional (3D) reconstruction and morphological measurement techniques reconstruct stereoscopic models all pulmonary segments, measured length each segment along lobe's landmark lines. Methods: We downloaded primary computed tomography (CT) scan data 619 patients imported...
Primary mediastinal myelolipoma (PMM) is a rare benign tumour composed of haematopoietic tissue and mature adipose tissue. Here, we report the largest series aiming to investigate outcomes surgical treatment for patients with PMM.We retrospectively reviewed data 12 operated in single institute during period between April 2008 December 2014.There were 7 female 5 male 54 73 years old (median age, 64 years). Among them, 11 underwent unilateral (n = 10) or bilateral 1) mass resection via...