A5023015887- Acute Lymphoblastic Leukemia research
- Histiocytic Disorders and Treatments
- Acute Myeloid Leukemia Research
- Vascular Malformations and Hemangiomas
- Cardiovascular Effects of Exercise
- Immunodeficiency and Autoimmune Disorders
- Childhood Cancer Survivors' Quality of Life
- Hematopoietic Stem Cell Transplantation
- CAR-T cell therapy research
- Viral-associated cancers and disorders
- Cardiac electrophysiology and arrhythmias
- Virus-based gene therapy research
- Renal and related cancers
- Tumors and Oncological Cases
- Autoimmune and Inflammatory Disorders Research
- Parvovirus B19 Infection Studies
- Neutropenia and Cancer Infections
- Platelet Disorders and Treatments
- Chronic Myeloid Leukemia Treatments
- Genital Health and Disease
- Central Venous Catheters and Hemodialysis
- CNS Lymphoma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Acute Kidney Injury Research
- Genetic Neurodegenerative Diseases
Sichuan University
2009-2025
West China Second University Hospital of Sichuan University
2016-2025
Shenzhen Children's Hospital
2021-2024
Yunnan Institute of Endemic Diseases Control and Prevention
2018-2023
Fudan University
2023
National Health and Family Planning Commission
2023
Baoding People's Hospital
2021
Children's Hospital of Chongqing Medical University
2020
Chongqing Medical University
2012-2020
West China Hospital of Sichuan University
2017-2019
Langerhans cell histiocytosis (LCH) is characterized genetically by diverse gene mutations of the mitogen-activated protein kinase signaling cascade. BRAF N486_T491delinsK mutation a rare that involves β2-αC ring domain, causing activation pathway, and predicted to be resistant chemotherapy V600E inhibitor in adult LCH cases. Here, we report childhood case with this novel had good response conventional chemotherapy. This suggests children might differ from counterparts terms clinical...
Langerhans cell histiocytosis (LCH) is a myeloid neoplasm associated with the infiltration of most organs but rarely involves stomach. Stomach tumors in children are very rare and can be easily misdiagnosed. We report first case gastric LCH 9-year-old boy who was misdiagnosed lymphoma. The patient presented to our outpatient department recurrent abdominal pain that had lasted 1 month. Due absence typical clinical features lymphoma boy, initial diagnosis based on pathological biopsy...
Contemporary osteoporosis treatment often neglects the intricate interactions among immune cells, signaling proteins, and cytokines within osteoporotic microenvironment. Here, we developed core-shell nanocapsules composed of a cationized lactoferrin core an alendronate polymer shell. By tuning size these leveraging shell, enabled precise delivery small interfering RNA targeting Semaphorin 4D gene (siSema4D) to specific bone sites. This strategy integrates antiresorptive drug with siSema4D,...
ABSTRACT The demand for double‐filtration plasmapheresis (DFPP) in clinical settings is growing steadily, yet the range and availability of specialized equipment designed to support DFPP are relatively limited. We aimed assess efficacy safety a auxiliary line treatment using standard continuous renal replacement (CRRT) machines. This prospective self‐controlled study was conducted between May 2021 April 2024. Patients who underwent both machines CRRT (using line) were enrolled study....
Abstract Recombinant adeno‐associated viruses (rAAVs) have emerged as promising vaccine vectors due to their enduring efficacy with a single dose. However, insufficient cellular immune responses and the random non‐specific distribution of AAVs post‐injection may hinder development AAV vaccines. Here, novel Pickering emulsion platform stabilized by biomineralized manganese nanoparticles aluminum hydroxide, which can rapidly efficiently load AAVs, is reported. This confers favorable in vivo...
Tumor vaccines that activate the autologous immune system to eliminate tumor cells represent a promising approach in cancer immunotherapy. However, challenges such as heterogeneity, limited antigen selection, insufficient presentation, and slow onset of de novo responses have resulted poor universality suboptimal response rates. In contrast, pathogen-specific pre-existing immunity acquired through infection or vaccination, can rapidly generate more potent enduring upon re-encounter with same...
Background This study aimed to understand the clinical characteristics and outcomes of children with Langerhans cell histiocytosis (LCH) in China.Methods We conducted a retrospective 95 paediatric patients LCH West China Second University Hospital Sichuan between July 2013 August 2020.Results The onset age multisystem (MS-LCH) risk organ (RO) involvement was younger than that MS-LCH without RO (p = .002) single system < .001) patients; bone most frequently involved organ, followed by skin....
To determine the association of excessive daytime sleepiness (EDS) with conversion neurodegenerative diseases in patients idiopathic REM sleep behavior disorder (iRBD). A total 179 iRBD (79.1% males, mean age = 66.3 ± 9.8 years) were consecutively recruited. Forty-five Epworth Sleepiness Scale score ≥ 14 defined as having EDS. Demographic, clinical and polysomnographic data compared between without The risk developing was examined using Cox proportional hazards model. After a follow-up 5.8...
This study aimed to assess the different types of port-wine stain (PWS) skin lesions quantitatively using high-frequency ultrasound (US) and shear wave elastography (SWE) before after treatment, investigate feasibility application value US SWE in PWSs.A total 195 PWS patients with 238 treatment 72 follow-up 90 were assessed SWE. The divided into four groups: pink-type, purple-type, thickened-type, nodular-type PWSs. Gray-scale was used observe normal skin, changes lesions, thickness....
Abstract Background Central nervous system leukemia (CNSL) is one of the major causes poor prognosis childhood leukemia. We aimed to compare sensitivity cytomorphology (CM) and flow cytometry (FCM) in diagnosing CNSL, emphasizing importance FCM diagnosis process. Methods One-hundred-sixty-five children with newly diagnosed B-cell Acute Lymphoblastic Leukemia (B-cell ALL) were included this study. Cerebrospinal fluid (CSF) samples taken for routine CSF analysis, CM examination. Computed...
Asthma is the most common disease in children, and its pathogenesis highly complicated.CD4+ cells CD4+ IL-17+ were analysed by flow cytometry, ratio of to peripheral blood mononuclear (PBMCs) PMBCs calculated from control group, acute moderate group. The levels protein expression IL-6, IL-17, IL-21 detected ELISA plasma culture supernatants PBMCs three groups. correlations between IL-7 groups.The mean cells/peripheral was 4.32% which higher than group IL-6 IL-17 elevated, decreased...
Despite much improvement in the treatment for acute lymphoblastic leukemia (ALL), childhood ALLs with MLL-rearrangement (MLL-r) still have inferior dismal prognosis. Thus, defining mechanisms underlying MLL-r ALL maintenance is critical developing effective therapy.GSE13159 and GSE28497 were selected via Oncomine website. Differentially expressed genes (DEGs) between normal samples identified by R software. Next, functional enrichment analysis of these DEGs carried out Gene Ontology (GO),...
Long QT syndrome (LQTS) is known to be involved in some sudden unexplained death (SUD) cases. To make clear whether the pathogenic genes of LQTS are SUD Yunnan province, southwest China, we examined 4 mutation hotspot segments KCNQ1, KCNH2, and SCN5A 83 cases using polymerase chain reaction direct DNA sequencing. Genomic was extracted from paraffin-embedded tissues cardiac death. One novel homozygous missense variant identified exon 3 c. 575G>T (p.R192L) one case. heterozygous 7 c.1789T>A...
Hereditary thrombotic thrombocytopenic purpura (TTP) is caused by ADAMTS13 mutations with autosomal recessive inheritance. It typically presents during childhood and frequently misdiagnosed as immune thrombocytopenia.We present a case of hereditary TTP an undescribed compound heterozygous mutation in Chinese boy. A 12-year boy history intermittent thrombocytopenia the prior 6 years had severe deficiency plasma harbored novel which was also identified his sister. The c.577CT pathogenic...
Abstract Rationale: Familial hemophagocytic lymphohistiocytosis (FHL) is a fatal autosomal recessive immunodeficiency disease whose rapid and accurate diagnosis paramount for appropriate treatment. Mutations in STXBP2 gene have been associated with FHL type 5 (FHL-5). Here, we report the first Tibetan Chinese patient diagnosed FHL-5 caused by novel compound heterozygous mutation . Patient concerns: A 9-year-old girl who presented recurrent fever, splenomegaly, pancytopenia,...
Background: A 12-year-old girl diagnosed with intermediate risk B-ALL in 2017 received chemotherapy according to CCLG-2008 ALL protocol and achieved a complete remission (CR) after induction. However, four years later, she had first bone marrow relapse treatment HKPHOSG Relapsed 2007 protocol. During maintenance chemotherapy, approximately one year the relapse, developed second NT5C2 gene mutation detected. Tumor burden was not well controlled DEAV blasts increasing from 49.3% 96%. The...