A5035482209- Neuroscience and Neuropharmacology Research
- Neuroscience of respiration and sleep
- Neurological disorders and treatments
- Vestibular and auditory disorders
- Parkinson's Disease Mechanisms and Treatments
- Neurogenesis and neuroplasticity mechanisms
- Neuropeptides and Animal Physiology
- Nerve injury and regeneration
- Sleep and Wakefulness Research
- Iron Metabolism and Disorders
- Receptor Mechanisms and Signaling
- Neural dynamics and brain function
- Hearing, Cochlea, Tinnitus, Genetics
- Glaucoma and retinal disorders
- Neuroscience and Neural Engineering
- Neuroendocrine regulation and behavior
- Circadian rhythm and melatonin
- Ion channel regulation and function
- Trace Elements in Health
- Hemoglobinopathies and Related Disorders
- Neurobiology and Insect Physiology Research
- Neurotransmitter Receptor Influence on Behavior
- Regulation of Appetite and Obesity
- Photoreceptor and optogenetics research
- Memory and Neural Mechanisms
City University of Hong Kong
2023-2025
Chinese University of Hong Kong
2015-2024
Prince of Wales Hospital
2022-2024
Hong Kong Jockey Club
2024
University of Hong Kong
1990-2015
Hospital Authority
2012
Hong Kong University of Science and Technology
2005-2012
Cornell University
2004
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2004
Harvard University Press
2001
Long-term memory is thought to be mediated by protein synthesis-dependent, late-phase long-term potentiation (L-LTP). Two secretory proteins, tissue plasminogen activator (tPA) and brain-derived neurotrophic factor (BDNF), have been implicated in this process, but their relationship unclear. Here we report that tPA, activating the extracellular protease plasmin, converts precursor proBDNF mature BDNF (mBDNF), such conversion critical for L-LTP expression mouse hippocampus. Moreover,...
Much recent discussion about the origin of Parkinsonian symptoms has centered around idea that they arise with increase beta frequency waves in EEG. This activity may be closely related to an oscillation between subthalamic nucleus (STN) and globus pallidus. Since STN is target deep brain stimulation, it had been assumed its action on itself. By means simultaneous recordings firing activities from populations neurons local field potentials motor cortex freely moving rats, this study casts...
1. The membrane properties of substantia nigra pars compacta neurones were studied using an in vitro slice preparation guinea-pig midbrain. 2. Neurones divided into two classes based on their electrophysiological properties: bursting displayed a burst several rapidly accommodating action potentials response to relaxation hyperpolarizing current injected through the microelectrode, while non-bursting produced regularly spaced potentials. These neuronal types found be electrophysiologically...
To monitor and measure dendritic shrinkage of retinal ganglion cells (RGCs) in a strain transgenic mice (Thy-1 YFP) that expresses yellow fluorescent proteins neurons under the control Thy-1 promoter.A total 125 RGCs from 16 eyes YFP were serially imaged with confocal scanning laser ophthalmoscope for 6 months after optic nerve crush. Quantitative analysis cell body area, axon diameter, field, number terminal branches, branch length, branching complexity, symmetry, distance disc was used to...
The functional integrity of the neocortex depends upon proper numbers excitatory and inhibitory neurons; however, consequences dysregulated neuronal production during development are unclear. As excess cortical neurons linked to neurodevelopmental disorder autism, we investigated whether overproduction leads neocortical malformation malfunction in mice. We experimentally increased number pyramidal upper layers by using small molecule XAV939 expand intermediate progenitor population....
Significance Synaptic plasticity in the hippocampus is important for learning and memory formation. In particular, homeostatic synaptic enables neurons to restore their activity levels response chronic neuronal changes. While astrocytes modulate functions via secretion of factors, underlying molecular mechanisms remain unclear. Here, we show that suppression hippocampal increases cytokine IL-33 release from CA1 region. Activation its ST2 receptor complex promotes functional excitatory...
Abstract Prolonged exposure to negative stressors could be harmful if a subject cannot respond appropriately. Strategies evolved stress, including repetitive displacement behaviours, are important in maintaining behavioural homoeostasis. In rodents, self-grooming is frequently observed behaviour believed contribute post-stress de-arousal with adaptive value. Here we identified rat limbic di-synaptic circuit that regulates stress-induced positive affective valence. This links hippocampal...
The targeting and surface expression of membrane proteins are critical to their functions. In neurons, synaptic AMPA-type glutamate receptors were found be for plasticity such as long-term potentiation depression (LTD). PICK1 (protein interacting with C kinase 1) is a cytosolic protein that interacts many proteins, including AMPA via its PDZ (postsynaptic density-95/Discs large/zona occludens-1) domain. Its interactions regulate subcellular expression. However, the mechanism by which...
Hepcidin plays an essential role in maintaining normal iron homeostasis outside the brain. This recently discovered regulation hormone is predominantly expressed liver, and regulated by hypoxia. As antimicrobial peptide, this also elevated during infections inflammation. In study we investigated expression of hepcidin mRNA protein different brain regions, including cortex, hippocampus, striatum, substantia nigra, effects lipopolysaccharide (LPS) on using quantitative real-time RT-PCR...
Ligustilide, the main lipophilic component of Danggui, has been reported to protect brain against ischaemic injury. However, mechanisms are unknown. Here, we investigated roles erythropoietin (EPO) and stress-induced protein RTP801 in neuroprotection provided by ligustilide ischaemia-reperfusion (I/R) damage brain.The efficacy I/R was assessed neurological deficit, infarct volume cell viability, using middle cerebral artery occlusion model rats vivo rat cultured neurons vitro. EPO were...
This study examined the role of endoplasmic reticulum (ER) stress in mediating chronic intermittent hypoxia (IH)-induced neurocognitive deficits. We designed experiments to demonstrate that ER is initiated hippocampus under IH and determined its apoptotic cell death, impaired synaptic structure plasticity, memory deficits.Two weeks disrupted fine upregulated markers, glucose-regulated protein 78, caspase-12, C/EBP homologous protein, hippocampus, which could be suppressed by inhibitors,...
Abstract Blood pressure is maintained within a normal physiological range by sophisticated regulatory mechanism. Baroreceptors serve as frontline sensor to detect the change in blood pressure. Nerve signals are then sent cardiovascular control centre brain order stimulate baroreflex responses. Here, we identify TRPC5 channels mechanical aortic baroreceptors. In Trpc5 knockout mice, pressure-induced action potential firings afferent nerve and baroreflex-mediated heart rate reduction...