A5100402067- Axon Guidance and Neuronal Signaling
- Alzheimer's disease research and treatments
- Neuroscience and Neuropharmacology Research
- Bioinformatics and Genomic Networks
- Gut microbiota and health
- Neurogenesis and neuroplasticity mechanisms
- Signaling Pathways in Disease
- RNA Research and Splicing
- Tryptophan and brain disorders
- Genetic Associations and Epidemiology
- Ion channel regulation and function
- Apelin-related biomedical research
- Clostridium difficile and Clostridium perfringens research
- Metabolomics and Mass Spectrometry Studies
- Cholinesterase and Neurodegenerative Diseases
- S100 Proteins and Annexins
- Probiotics and Fermented Foods
- CRISPR and Genetic Engineering
- Machine Learning in Bioinformatics
- Retinal Development and Disorders
- Dementia and Cognitive Impairment Research
- Pain Mechanisms and Treatments
- Cytokine Signaling Pathways and Interactions
- Cellular Mechanics and Interactions
- MicroRNA in disease regulation
Hong Kong University of Science and Technology
2013-2025
University of Hong Kong
2013-2025
HKUST Shenzhen Research Institute
2013-2025
Chinese Academy of Sciences
2018-2025
University of Chinese Academy of Sciences
2018-2025
Shandong University
2025
Ruijin Hospital
2025
Shanghai Jiao Tong University
2025
Åbo Akademi University
2025
Shenzhen Institutes of Advanced Technology
2018-2024
<h3>Objectives:</h3> While plasma biomarkers have been proposed to aid in the clinical diagnosis of Alzheimer disease (AD), few validated independent patient cohorts. Here we aim determine associated with AD 2 cohorts and validate findings multicenter Alzheimer9s Disease Neuroimaging Initiative (ADNI). <h3>Methods:</h3> Using a targeted proteomic approach, measured levels 190 proteins peptides 600 participants from centers (University Pennsylvania, Philadelphia; Washington University, St....
Abstract Despite intense interests in developing blood measurements of Alzheimer’s disease (AD), the progress has been confounded by limited sensitivity and poor correlation to brain pathology. Here, we present a dedicated analytical platform for measuring different populations circulating amyloid β (Aβ) proteins – exosome-bound vs. unbound directly from blood. The technology, termed mplified p lasmonic ex osome (APEX), leverages situ enzymatic conversion localized optical deposits...
Blood proteins are emerging as candidate biomarkers for Alzheimer's disease (AD). We systematically profiled the plasma proteome to identify novel AD blood and develop a high-performance, blood-based test AD.
The gut microbiota (GM) and its metabolites affect the host nervous system are involved in pathogeneses of various neurological diseases. However, specific GM alterations under pathogenetic pressure their contributions to "microbiota – metabolite brain axis" Alzheimer's disease (AD) remain unclear. Here, we investigated fecal, serum, cortical metabolomes APP/PS1 wild-type (WT) mice, revealing distinct hub bacteria AD mice within scale-free networks shared by both groups. Moreover, identified...
Neurotrophins are key regulators of neuronal survival and differentiation during development. Activation their cognate receptors, Trk a family receptor tyrosine kinases (RTKs), is pivotal for mediating the downstream functions neurotrophins. Recent studies reveal that cyclin-dependent kinase 5 (Cdk5), serine/threonine kinase, may modulate RTK signaling through phosphorylation receptor. Given abundant expression both Cdk5 receptors in nervous system, mutual involvement regulation architecture...
Emerging evidence suggests that the gut microbiome actively regulates cognitive functions and imbalance is associated with Alzheimer’s disease (AD), most prevalent neurodegenerative disorder. However, changes in composition AD their association pathology, especially early stages, are unclear. Here, we compared profiles of microbiota between APP/PS1 transgenic mice (an mouse model) wild-type littermates at different ages by amplicon-based sequencing 16S ribosomal RNA genes. Microbiota started...
Abstract Alzheimer’s disease (AD) is a leading cause of mortality in the elderly. While coding change APOE -ε4 key risk factor for late-onset AD and has been believed to be only locus, it does not fully explain effect conferred by locus. Here, we report identification causal variants PVRL2 APOC1 regions proximity define common haplotypes independent change. These are associated with changes AD-related endophenotypes including cognitive performance, altered expression its nearby genes human...
Alzheimer’s disease (AD) is a leading cause of mortality among the elderly. We performed whole-genome sequencing study AD in Chinese population. In addition to variants identified or around APOE locus (sentinel variant rs73052335, P = 1.44 × 10 −14 ), two common variants, GCH1 (rs72713460, 4.36 −5 ) and KCNJ15 (rs928771, 3.60 −6 were further verified for their possible risk effects three small non-Asian cohorts. Genotype–phenotype analysis showed that rs928771 affects onset age AD, with...
Aplysiasecosterol A (1) is a structurally unusual 9,11-secosteroid isolated from the sea hare Aplysia kurodai. We have accomplished first and asymmetric total synthesis of 1 in convergent fashion. The left-hand segment bearing three adjacent stereocenters was constructed through desymmetrizing reduction, ketalization, radical cyclization. strategy 2-bromoallylation followed by spontaneous lactolization enabled more expeditious access to this segment. right-hand prepared two different...
Abstract Background The polygenic nature of Alzheimer’s disease (AD) suggests that multiple variants jointly contribute to susceptibility. As an individual’s genetic are constant throughout life, evaluating the combined effects disease-associated risks enables reliable AD risk prediction. Because complexity genomic data, current statistical analyses cannot comprehensively capture AD, resulting in unsatisfactory However, deep learning methods, which nonlinearity within high-dimensional may...
Alzheimer's disease (AD) is a debilitating neurodegenerative disorder with incidence expected to increase four-fold over the next decade. Extensive research efforts are focused upon identifying new treatments, and early diagnosis considered key successful intervention. Although imaging cerebrospinal fluid biomarkers have shown promise in patients very stages of disease, more noninvasive cost-effective tools remained elusive. Recent studies reported that an 18-analyte multiplexed plasma panel...
The intimate association between the gut microbiota (GM) and central nervous system points to potential intervention strategies for neurological diseases. Nevertheless, there is currently no theoretical framework selecting window period target bacteria GM interventions owing complexity of microecosystem. In this study, we constructed a complex network-based modeling approach evaluate topological features infer bacterial candidates interventions. We used Alzheimer's disease (AD) as an example...
Blood protein biomarkers demonstrate potential for Alzheimer's disease (AD) diagnosis. Limited studies examine the molecular changes in AD blood cells.
Precise regulation of cyclin-dependent kinase 5 (Cdk5), a member the family, is critical for proper neuronal development and functions. Cdk5 activated through its association with neuron-specific activator p35 or p39. Nonetheless, how activity regulated in neurons not well understood. In this study, we found that by S-nitrosylation, post-translational modification protein affects plethora S-nitrosylation occurs at Cys83, which one amino acids within ATP-binding pocket kinase. Upon exhibits...