A5009012652- Urinary Bladder and Prostate Research
- Bladder and Urothelial Cancer Treatments
- COVID-19 Clinical Research Studies
- Ferroptosis and cancer prognosis
- Prostate Cancer Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- Cancer, Lipids, and Metabolism
- Epigenetics and DNA Methylation
- Hormonal and reproductive studies
- Prostate Cancer Treatment and Research
- Urological Disorders and Treatments
- Long-Term Effects of COVID-19
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Renal cell carcinoma treatment
- Kidney Stones and Urolithiasis Treatments
- Sexual function and dysfunction studies
- Cancer, Hypoxia, and Metabolism
- Pediatric Urology and Nephrology Studies
- Ion Channels and Receptors
- Circular RNAs in diseases
- Pelvic floor disorders treatments
- RNA modifications and cancer
- Urinary and Genital Oncology Studies
- Renal and related cancers
Wuhan University
2016-2025
Zhongnan Hospital of Wuhan University
2016-2025
Dalian Medical University
2025
First Affiliated Hospital of Dalian Medical University
2025
Wuhan Wudong Hospital
2023-2025
Xiangya Hospital Central South University
2025
Central South University
2025
Pudong New Area People's Hospital
2025
Nanjing Medical University
2024-2025
Xinjiang Agricultural University
2025
<h3>Importance</h3> In December 2019, novel coronavirus (2019-nCoV)–infected pneumonia (NCIP) occurred in Wuhan, China. The number of cases has increased rapidly but information on the clinical characteristics affected patients is limited. <h3>Objective</h3> To describe epidemiological and NCIP. <h3>Design, Setting, Participants</h3> Retrospective, single-center case series 138 consecutive hospitalized with confirmed NCIP at Zhongnan Hospital Wuhan University China, from January 1 to 28,...
<h3>Importance</h3> Increasing numbers of confirmed cases and mortality rates coronavirus disease 2019 (COVID-19) are occurring in several countries continents. Information regarding the impact cardiovascular complication on fatal outcome is scarce. <h3>Objective</h3> To evaluate association underlying (CVD) myocardial injury with outcomes patients COVID-19. <h3>Design, Setting, Participants</h3> This retrospective single-center case series analyzed COVID-19 at Seventh Hospital Wuhan City,...
In December 2019, a new type viral pneumonia cases occurred in Wuhan, Hubei Province; and then named "2019 novel coronavirus (2019-nCoV)" by the World Health Organization (WHO) on 12 January 2020. For it is never been experienced respiratory disease before with infection ability widely quickly, attracted world's attention but without treatment control manual. request from frontline clinicians public health professionals of 2019-nCoV infected management, an evidence-based guideline urgently...
This is the first randomised controlled trial for assessment of immunogenicity and safety a candidate non-replicating adenovirus type-5 (Ad5)-vectored COVID-19 vaccine, aiming to determine an appropriate dose vaccine efficacy study.This randomised, double-blind, placebo-controlled, phase 2 Ad5-vectored was done in single centre Wuhan, China. Healthy adults aged 18 years or older, who were HIV-negative previous severe acute respiratory syndrome coronavirus (SARS-CoV-2) infection-free,...
Rationale: Use of ACEIs (angiotensin-converting enzyme inhibitors) and ARBs (angiotensin II receptor blockers) is a major concern for clinicians treating coronavirus disease 2019 (COVID-19) in patients with hypertension. Objective: To determine the association between in-hospital use ACEI/ARB all-cause mortality hypertension hospitalized due to COVID-19. Methods Results: This retrospective, multi-center study included 1128 adult diagnosed COVID-19, including 188 taking (ACEI/ARB group;...
Abstract Background No clinically proven effective antiviral strategy exists for the epidemic Coronavirus Disease 2019 (COVID-19). Methods We conducted a prospective, randomized, controlled, open-label multicenter trial involving adult patients with COVID-19. Patients were randomly assigned in 1:1 ratio to receive conventional therapy plus Umifenovir (Arbidol) (200mg*3/day) or Favipiravir (1600mg*2/first day followed by 600mg*2/day) 10 days. The primary outcome was clinical recovery rate of...
Abstract To explore any relationship between the ABO blood group and coronavirus disease 2019 (COVID-19) susceptibility, we compared distributions in 2173 COVID-19 patients with local control populations, found that A was associated an increased risk of infection, whereas O a decreased risk.
Abstract The novel coronavirus disease-2019 (COVID-19) has been spreading around the world rapidly and declared as a pandemic by WHO. Here, we compared ABO blood group distribution in 2,173 patients with COVID-19 confirmed SARS-CoV-2 test from three hospitals Wuhan Shenzhen, China that normal people corresponding regions. results showed A was associated higher risk for acquiring non-A groups, whereas O lower infection non-O groups. This is first observation of an association between type...
ObjectivesPrevious studies on the pneumonia outbreak caused by 2019 novel coronavirus disease (COVID-19) were based information from general population. However, limited data was available for severe acute respiratory syndrome 2 (SARS-CoV-2) reactivation. This study aimed to evaluate clinical characteristics of SARS-CoV-2 reactivation.MethodsClinical records, laboratory results, and chest CT scans retrospectively reviewed 55 patients with laboratory-confirmed COVID-19 (i.e., throat swab...
The sudden outbreak of novel coronavirus 2019 (COVID-19) increased the diagnostic burden radiologists. In time an epidemic crisis, we hoped artificial intelligence (AI) to help reduce physician workload in regions with outbreak, and improve diagnosis accuracy for physicians before they could acquire enough experience new disease. Here, present our building deploying AI system that automatically analyzes CT images detect COVID-19 pneumonia features. Different from conventional medical AI,...
SARS-CoV-2 has caused millions of deaths, and, since Aug 11, 2020, 20 intramuscular COVID-19 vaccines have been approved for use. We aimed to evaluate the safety and immunogenicity an aerosolised adenovirus type-5 vector-based vaccine (Ad5-nCoV) in adults without from China.This was a randomised, single-centre, open-label, phase 1 trial done Zhongnan Hospital (Wuhan, China), Ad5-nCoV by aerosol inhalation (≥18 years) seronegative SARS-CoV-2. Breastfeeding or pregnant women people with major...
Abstract Background Many healthcare workers were infected by coronavirus disease 2019 (COVID-19) early in the epidemic posing a big challenge for control. Hence, this study aims to explore perceived infection routes, influencing factors, psychosocial changes, and management procedures COVID-19 workers. Methods This is cross-sectional, single hospital-based study. We recruited all 105 confirmed Zhongnan Hospital of Wuhan University from February 15 29, 2020. All participants completed...
Persistent luminescence nanoparticles (PLNPs), which can remain luminescent after cessation of excitation, have emerged as important materials in biomedicine due to their special ability eliminate tissue autofluorescence. Even though significant advances been made bioimaging, studies on controlled synthesis PLNPs with tunable properties are lacking. Until now, only a few reported the quasi-spherical ZnGa2O4:Cr PLNPs, and direct other shapes chemical compositions has not reported. Herein, we...
BackgroundCoronavirus disease 2019 (COVID-19) has been widely spread and caused tens of thousands deaths, especially in patients with severe COVID-19. This analysis aimed to explore risk factors for mortality COVID-19, establish a scoring system predict in-hospital deaths.MethodsPatients COVID-19 were retrospectively analyzed clinical characteristics compared. LASSO regression as well multivariable used screen variables prediction model.FindingsA total 2529 was analyzed, 452 eligible finally...
Background: In addition to supportive therapy, antiviral therapy is an effective treatment for coronavirus disease 2019 (COVID-19). Objective: To compare the efficacy and safety of favipiravir umifenovir (Arbidol) treat COVID-19 patients. Methods: We conducted a prospective, randomized, controlled, open-label multicenter trial involving adult patients with COVID-19. Enrolled initial symptoms within 12 days were randomly assigned in 1:1 ratio receive conventional plus Arbidol (200 mg*3/day)...
The burden of kidney, bladder, and prostate cancers has changed in recent decades. This study aims to investigate the global regional of, attributable risk factors for genitourinary during past 30 years.
All known triterpenes are generated by triterpene synthases (TrTSs) from squalene or oxidosqualene1. This approach is fundamentally different the biosynthesis of short-chain (C10-C25) terpenes that formed polyisoprenyl diphosphates2-4. In this study, two fungal chimeric class I TrTSs, Talaromyces verruculosus talaropentaene synthase (TvTS) and Macrophomina phaseolina macrophomene (MpMS), were characterized. Both enzymes use dimethylallyl diphosphate isopentenyl hexaprenyl as substrates,...