A5054174618- Radiomics and Machine Learning in Medical Imaging
- Cancer, Hypoxia, and Metabolism
- Medical Research and Treatments
- Liver Disease Diagnosis and Treatment
- MRI in cancer diagnosis
- Advanced Neuroimaging Techniques and Applications
- Lung Cancer Diagnosis and Treatment
- Advanced X-ray and CT Imaging
- Medical Imaging Techniques and Applications
- Nanoplatforms for cancer theranostics
- Advanced MRI Techniques and Applications
- Traditional Chinese Medicine Studies
- Renal cell carcinoma treatment
- Radiation Dose and Imaging
- Peptidase Inhibition and Analysis
- MicroRNA in disease regulation
- Cancer Mechanisms and Therapy
- Adipose Tissue and Metabolism
- Cannabis and Cannabinoid Research
- Ubiquitin and proteasome pathways
- Neuroscience and Neuropharmacology Research
- Ferroptosis and cancer prognosis
- Histone Deacetylase Inhibitors Research
- Pediatric Hepatobiliary Diseases and Treatments
- Medical Imaging and Pathology Studies
Second People 's Hospital of Jinzhong
2024
Chenzhou First People's Hospital
2024
University of South China
2024
Chongqing Medical University
2024
Children's Hospital of Chongqing Medical University
2024
University of Electronic Science and Technology of China
2024
Peking University
2008-2024
Peking University Third Hospital
2024
Tianjin Medical University General Hospital
2005-2024
Sichuan University
2012-2023
This is the first randomised controlled trial for assessment of immunogenicity and safety a candidate non-replicating adenovirus type-5 (Ad5)-vectored COVID-19 vaccine, aiming to determine an appropriate dose vaccine efficacy study.This randomised, double-blind, placebo-controlled, phase 2 Ad5-vectored was done in single centre Wuhan, China. Healthy adults aged 18 years or older, who were HIV-negative previous severe acute respiratory syndrome coronavirus (SARS-CoV-2) infection-free,...
Our understanding of the bile acid metabolism is limited by fact that previous analyses have primarily focused on a selected few circulating acids; profiles liver and gastrointestinal tract pools are rarely investigated. Here, we determined how chronic ethanol consumption altered acids in multiple body compartments (liver, tract, serum) rats. Rats were fed modified Lieber-DeCarli liquid diet with 38% calories as (the amount equivalent 4–5 drinks humans). While conjugated predominated...
Background: People with a new colostomy encounter many difficulties as they struggle to adjust their ostomies. Nurse telephone follow-up is convenient way ensure continuity of care. There paucity studies testing if nurse can enhance adjustment postdischarged patients. Objectives: The purpose this study was evaluate the effect enterostomal on levels discharged Methods: This randomized controlled trial. Participants (n = 103) who had undergone operations in China were recruited and randomly...
A loss-of-function mutation (Q141K, rs2231142) in the ATP-binding cassette, subfamily G, member 2 gene (ABCG2) has been shown to be associated with serum uric acid levels and gout Asians, Europeans, European African Americans; however, less is known about these associations other populations. Rs2231142 was genotyped 22,734 Americans, 9,720 3,849 Mexican 3,550 American Indians Population Architecture using Genomics Epidemiology (PAGE) Study (2008-2012). significantly (P = 2.37 × 10(-67), P...
Background: Isorhamnetin (Iso), a novel and essential monomer derived from total flavones of Hippophae rhamnoides that has long been used as traditional Chinese medicine for angina pectoris acute myocardial infarction, also shown spectrum antitumor activity. However, little is known about the mechanisms action Iso on cancer cells. Objectives: To investigate effects A549 lung cells underlying mechanisms. Materials Methods: were treated with <TEX>$10{\sim}320{\mu}g/ml$</TEX> Iso. Their...
We developed a risk score for contrast-induced nephropathy (CIN) in elderly patients (n = 668) before percutaneous coronary intervention (PCI). Another 277 were studied validation. Based on the odds ratio, factors assigned weighted integer; sum of integers was score. Among 668 patients, 105 (15.7%) experienced CIN. There 9 CIN (with integer): estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m(2) (4), diabetes (3), left ventricular ejection fraction <45% hypotension (2), age >70...
Abstract The situation of the coronavirus disease 2019 (COVID‐19) continues to evolve, our study explored significance serum levels matrix metalloproteinase 3 (MMP3) as a marker for patients with COVID‐19. Sixty‐two COVID‐19 in First Hospital Hunan University Chinese Medicine and Loudi Center Diseases Prevention Control, from January March 2020, were sampled novel pneumonia infected group. One hundred thirty‐one cases Medicine, including 67 healthy individuals 64 non‐COVID‐19 inpatients,...
Abstract ErbB2 overexpression identifies a subclass of breast cancer as ErbB2-positive that is frequently associated with poor prognosis. Current ErbB2-targeted therapies have profoundly improved patient outcomes, but mutations occurring in been shown to confer drug resistance. Induction degradation was proposed an intriguing strategy battle and reduced mutation-incurred Although multiple HSP90 inhibitors demonstrated effectively trigger degradation, none succeeded the clinical evaluations....
Abstract Chemo‐phototherapy has emerged as a promising approach to complement traditional cancer treatment and enhance therapeutic effects. However, it still faces the challenges of drug efflux transporter‐mediated chemoresistance heat shock proteins (HSPs)‐mediated phototherapy tolerance, which both depend on an excessive supply adenosine triphosphate. Therefore, manipulating energy metabolism impair expression or function P‐glycoprotein (P‐gp) HSPs may be prospective strategy reverse...
The excessive use of antibiotics has precipitated the emergence drug-resistant bacterial strains, underscoring critical necessity for development novel, targeted antimicrobial agents. Among burgeoning class nanomaterials, silver clusters have attracted considerable attention due to their broad-spectrum and enduring properties, coupled with crucial advantage not eliciting resistance. These features render them exceptionally promising in landscape therapy. Nevertheless, constraints associated...
Primary intraosseous squamous cell carcinoma is a rare form of carcinoma, arising within the jaws.To clarify clinicopathologic and behavioral spectrum primary carcinoma.The clinical pathologic findings, treatment, follow-up data 39 cases were collected analyzed.Of patients, 26 (67%) men 13 (33%) women. The age at diagnosis ranged from 24 to 82 years (mean, 54 years). tumors occurred predominantly (84.6%) in posterior mandible. Microscopically, all demonstrated general features carcinoma; 19...
White adipose tissue (WAT) secretes adipokines, which critically regulate lipid metabolism. The present study investigated the effects of alcohol on adipokines and mechanistic link between adipokine dysregulation alcoholic fatty liver disease. Mice were fed for 2, 4, or 8 weeks to document changes in over time. Alcohol exposure reduced WAT mass body weight association with hepatic accumulation. plasma adiponectin concentration was increased at 2 weeks, but declined normal 4 weeks. suppressed...
Effective treatment for pancreatic ductal adenocarcinoma (PDAC) is an urgent, unmet medical need. Targeting KRAS, the oncogene that present in >95% of PDAC, a heavily pursued strategy, but remains unsuccessful clinic. Therefore, targeting key effector cascades KRAS oncoprotein, particularly mitogenic RAF-MEK-ERK pathway, represents next best strategy. However, RAF or MEK inhibitors have failed to show clinical efficacy PDAC. Several studies shown cancer cells treated with adopt multiple...
Background Nuclear grade is of importance for treatment selection and prognosis in patients with clear cell renal carcinoma (ccRCC). Purpose To develop validate an MRI‐based radiomic model preoperative predicting WHO/ISUP nuclear ccRCC. Study Type Retrospective. Population In all, 379 histologically confirmed Training cohort ( n = 252) validation 127) were randomly assigned. Field Strength/Sequence Pretreatment 3.0T MRI. Imaging sequences fat‐suppressed T 2 WI, contrast‐enhanced 1 diffusion...
Gastric cancer is a common malignant tumor. The aim of the present study was to analyze application value serum pepsinogen (PG), carbohydrate antigen 72-4 (CA72-4), and gastrin-17 (G-17) detection in screening, diagnosis, evaluation early gastric cancer.In total, 122 patients with treated our hospital from January 2018 2021 were selected as group subdivided into (group A) advanced B) groups. Sixty-five benign disease same during period control group, healthy people who underwent physical...
Lung cancer is one of the most frequent causes cancer-related deaths worldwide. Drug repurposing and nano-drug delivery systems are attracting considerable attention for improving anti-cancer therapy. Sertaconazole (STZ), an antifungal agent, has been reported to exhibit cytotoxicity against both normal tumor cells, its medical use limited by poor solubility. In order overcome such shortcomings, we prepared a drug-repurposed nanoplatform enhance anti-tumor efficiency. Nanoplatform was thin...