A5064977813- Cardiovascular Disease and Adiposity
- Peripheral Artery Disease Management
- Cardiovascular Health and Risk Factors
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Blood Pressure and Hypertension Studies
- Cardiovascular Health and Disease Prevention
- Nutritional Studies and Diet
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Obesity, Physical Activity, Diet
- Diagnosis and Treatment of Venous Diseases
- Diabetic Foot Ulcer Assessment and Management
- Sodium Intake and Health
- Heart Rate Variability and Autonomic Control
- Cardiac Health and Mental Health
- Adipokines, Inflammation, and Metabolic Diseases
- Lymphatic System and Diseases
- Cerebrovascular and Carotid Artery Diseases
- Lipoproteins and Cardiovascular Health
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Birth, Development, and Health
- Health disparities and outcomes
- Sleep and related disorders
- Acute Myocardial Infarction Research
- Liver Disease Diagnosis and Treatment
Northwestern University
2015-2024
National Heart Lung and Blood Institute
2006-2018
Columbia University
2003-2018
Johns Hopkins University
2008-2018
University of Washington
2005-2018
Wake Forest University
2008-2018
National Institute of Biomedical Imaging and Bioengineering
2013-2018
National Institutes of Health Clinical Center
2017-2018
Rutgers, The State University of New Jersey
2018
Rutgers New Jersey Medical School
2018
In white populations, computed tomographic measurements of coronary-artery calcium predict coronary heart disease independently traditional risk factors. However, it is not known whether predicts in other racial or ethnic groups.We collected data on factors and performed scanning for a population-based sample 6722 men women, whom 38.6% were white, 27.6% black, 21.9% Hispanic, 11.9% Chinese. The study subjects had no clinical cardiovascular at entry followed median 3.8 years.There 162 events,...
Background: Recent epidemiologic studies have found that self-reported duration of sleep is associated with obesity, diabetes, hypertension, and mortality. The extent to which self reports are similar objective measures whether individual characteristics influence the degree similarity not known. Methods: Eligible participants at Chicago site Coronary Artery Risk Development in Young Adults Study were invited participate a 2003–2005 ancillary study; 82% (n = 669) agreed. Sleep measurements...
We prospectively followed 1213 black girls and 1166 white enrolled in the National Heart, Lung, Blood Institute Growth Health Study from ages of 9 or 10 to 18 19 years. used a validated questionnaire measure leisure-time physical activity on basis metabolic equivalents (MET) for reported activities their frequency MET-times per week; higher score indicated greater activity.
Epidemiologic data on the possible benefit of eating fish to reduce risk coronary heart disease have been inconsistent. We used from Chicago Western Electric Study examine relation between base-line consumption and 30-year death disease.
Persons with lower-extremity peripheral arterial disease (PAD) are often asymptomatic or have leg symptoms other than intermittent claudication (IC).To identify clinical characteristics and functional limitations associated a broad range of identified among patients PAD.Cross-sectional study 460 men women PAD 130 without PAD, who were consecutively, conducted between October 1998 January 2000 at 3 Chicago-area medical centers.Ankle-brachial index score less 0.90; scores from 6-minute walk,...
Conventional coronary artery disease (CAD) risk factors fail to explain nearly 50% of CAD events. This study examines the association between electron-beam tomography (EBT) calcium (CAC) and cardiac events in initially asymptomatic low- intermediate-risk individuals, with adjustment for presence hypercholesterolemia, hypertension, diabetes, a history cigarette smoking.The was performed 8855 adults 30 76 years old (26% women) who self-referred EBT CAC screening. were elicited by use...
There is substantial evidence that coronary calcification, a marker for the presence and quantity of atherosclerosis, higher in US whites than blacks; however, there have been no large population-based studies comparing calcification among ethnic groups.Using computed tomography, we measured 6814 white, black, Hispanic, Chinese men women aged 45 to 84 years with clinical cardiovascular disease who participated Multi-Ethnic Study Atherosclerosis (MESA). The prevalence (Agatston score >0)...
Context-Coronary artery calcium (CAC) and carotid intima-media thickness (IMT) are noninvasive measures of atherosclerosis that consensus panels have recommended as possible additions to risk factor assessment for predicting the probability cardiovascular disease (CVD) occurrence.Objective-To assess whether maximum IMT or CAC (Agatston Score) is better predictor incident CVD.Design, Setting, Patients-Prospective cohort study 45-84 year-olds initially free CVD (n = 6,698) in four ethnic...
Low cardiorespiratory fitness is an established risk factor for cardiovascular and total mortality; however, mechanisms responsible these associations are uncertain.To test whether low fitness, estimated by short duration on a maximal treadmill test, predicted the development of disease factors improving (increase in between examinations) was associated with reduction.Population-based longitudinal cohort study men women 18 to 30 years age Coronary Artery Risk Development Young Adults...
Among individuals with lower-extremity peripheral arterial disease (PAD), specific leg symptoms and the ankle brachial index (ABI) are cross-sectionally related to degree of functional impairment. However, relations between these clinical characteristics objectively measured decline unknown.To define whether PAD, ABI, predict at 2-year follow-up.Prospective cohort study among 676 consecutively identified (aged > or =55 years) without PAD (n = 417 n 259, respectively), baseline assessments...
Despite mounting evidence that sleep duration is a risk factor across diverse health and functional domains, little known about the distribution determinants of sleep. In 2003–2004, authors used wrist activity monitoring logs to measure time in bed, latency (time required fall asleep), duration, efficiency (percentage bed spent sleeping) over 3 days for 669 participants at one four sites Coronary Artery Risk Development Young Adults (CARDIA) study (Chicago, Illinois). Participants were aged...
Type 2 diabetes in normal-weight adults (body mass index [BMI] <25) is a representation of the metabolically obese phenotype with unknown mortality consequences.To test association weight status new-onset order to minimize influence duration and voluntary loss on mortality.Pooled analysis 5 longitudinal cohort studies: Atherosclerosis Risk Communities study, 1990-2006; Cardiovascular Health Study, 1992-2008; Coronary Artery Development Young Adults, 1987-2011; Framingham Offspring 1979-2007;...
The relationship between incident congestive heart failure (CHF) and ethnicity as well racial/ethnic differences in the mechanisms leading to CHF have not been demonstrated a multiracial, population-based study. Our objective was evaluate race/ethnicity CHF.The Multi-Ethnic Study of Atherosclerosis (MESA) is cohort study 6814 participants 4 ethnicities: white (38.5%), African American (27.8%), Hispanic (21.9%), Chinese (11.8%). Participants with history cardiovascular disease at baseline...
The ankle brachial index (ABI) is a noninvasive, reliable measure of lower-extremity ischemia. However, the relationship between ABI and function has not been well studied.To describe association function.Cross-sectional study.3 academic medical centers in Chicago area.740 men women (460 with peripheral arterial disease).Accelerometer-measured physical activity over 7 days, 6-minute walk, 4-m walking velocity, standing balance, ABI.33% participants disease had intermittent claudication....
Rationale: Machine learning may be useful to characterize cardiovascular risk, predict outcomes, and identify biomarkers in population studies. Objective: To test the ability of random survival forests, a machine technique, 6 outcomes comparison standard risk scores. Methods Results: We included participants from MESA (Multi-Ethnic Study Atherosclerosis). Baseline measurements were used over 12 years follow-up. was designed study progression subclinical disease events where initially free...
Neither supervised treadmill exercise nor strength training for patients with peripheral arterial disease (PAD) without intermittent claudication have been established as beneficial.
Previous studies reported an increased risk of pancreatic cancer among persons with diabetes. Few data exist, however, on the association postload plasma glucose concentration cancer, which could provide insight into role abnormal metabolism in etiology cancer.To determine independent between and mortality without self-reported diabetes.Prospective cohort study.Employees 84 Chicago-area organizations, average age 40 years at baseline, were screened from 1963 to 1973 followed up for 25 years....
Background: Epidemiological studies have reported an association between self-reported short sleep duration and high blood pressure (BP).Our objective was to examine both cross-sectional longitudinal associations objectively measured BP.Methods: This study is ancillary the Coronary Artery Risk Development in Young Adults (CARDIA) cohort study.Blood 2000 2001 2005 2006.Sleep twice using wrist actigraphy for 3 consecutive days 2003 2005.Sleep maintenance (a component of quality) were...