A5017243866- Lipoproteins and Cardiovascular Health
- Cardiac Imaging and Diagnostics
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular Function and Risk Factors
- Cardiovascular Health and Risk Factors
- Cardiovascular Disease and Adiposity
- Acute Myocardial Infarction Research
- Health Systems, Economic Evaluations, Quality of Life
- Adipokines, Inflammation, and Metabolic Diseases
- Blood Pressure and Hypertension Studies
- Cardiac Health and Mental Health
- Cancer, Lipids, and Metabolism
- Atherosclerosis and Cardiovascular Diseases
- Liver Disease Diagnosis and Treatment
- Cardiovascular Health and Disease Prevention
- Nutritional Studies and Diet
- Heart Failure Treatment and Management
- Cardiovascular and exercise physiology
- Lipid metabolism and disorders
- Cardiovascular Effects of Exercise
- Pharmaceutical Economics and Policy
- Cerebrovascular and Carotid Artery Diseases
- Diabetes Treatment and Management
- Genetic Associations and Epidemiology
- Health disparities and outcomes
Parkland Health & Hospital System
2022-2025
The University of Texas Southwestern Medical Center
2016-2025
Southwestern Medical Center
2016-2025
Swami Vivekanand Subharti University
2025
Brigham and Women's Hospital
2005-2024
Harvard University
2013-2024
Massachusetts General Hospital
2015-2024
Verve Therapeutics (United States)
2023-2024
Broad Institute
2016-2023
National Institute on Minority Health and Health Disparities
2023
High-density lipoprotein (HDL) may provide cardiovascular protection by promoting reverse cholesterol transport from macrophages. We hypothesized that the capacity of HDL to accept macrophages would serve as a predictor atherosclerotic burden.We measured efflux in 203 healthy volunteers who underwent assessment carotid artery intima-media thickness, 442 patients with angiographically confirmed coronary disease, and 351 without such disease. quantified using validated ex vivo system involved...
It is unclear whether high-density lipoprotein (HDL) cholesterol concentration plays a causal role in atherosclerosis. A more important factor may be HDL efflux capacity, the ability of to accept from macrophages, which key step reverse transport. We investigated epidemiology capacity and its association with incident atherosclerotic cardiovascular disease outcomes large, multiethnic population cohort.We measured level, particle concentration, at baseline 2924 adults free who were...
<h3>Context</h3>Detectable levels of cardiac troponin T (cTnT) are strongly associated with structural heart disease and increased risk death adverse cardiovascular events; however, cTnT is rarely detectable in the general population using standard assays.<h3>Objectives</h3>To determine prevalence determinants a new highly sensitive assay to assess whether measured associate pathological phenotypes subsequent mortality.<h3>Design, Setting, Participants</h3>Cardiac were both assays 3546...
THEprevalence of overweight and obesity 1 has contributed to a doubling in type 2 diabetes mellitus incidence over the past 3 decades. 2Increasing rates among obese individuals counterbalanced reductions other cardiovascular disease (CVD) risk factors is primary factor contributing slowed decline CVD event general population. 3Prediabetes, an intermediate hyperglycemia phenotype for diabetes, 4 also associated with carries excess death. 5lthough increased body mass index (BMI) at population...
Background— The prevalence and determinants of cardiac troponin T (cTnT) elevation in the general population are unknown, significance minimally increased cTnT remains controversial. Our objective was to determine a large, representative sample population. Methods Results— measured from stored plasma samples 3557 subjects Dallas Heart Study, population-based sample. (≥0.01 μg/L) correlated with clinical variables MRI findings. weight-adjusted 0.7%. In univariable analyses, associated older...
Visceral (VAT) and abdominal subcutaneous (SAT) adipose tissues contribute to obesity but may have different metabolic atherosclerosis risk profiles. We sought determine the associations of VAT SAT mass with markers cardiac in a large, multiethnic, population-based cohort obese adults.Among participants Dallas Heart Study, we examined cross-sectional mass, assessed by magnetic resonance imaging (MRI) indexed body surface area (BSA), circulating biomarkers insulin resistance, dyslipidemia,...
Background— Lipoprotein(a) [Lp(a)] is a low-density lipoprotein–like particle largely independent of known risk factors and predictive cardiovascular disease. Statins may offset the associated with elevated Lp(a), but it unknown whether Lp(a) determinant residual in setting low lipoprotein cholesterol after potent statin therapy. Methods Results— Baseline on-treatment concentrations were assessed 9612 multiethnic participants JUPITER trial (Justification for Use Prevention: An Intervention...
Statins remain a mainstay in the prevention and treatment of atherosclerotic cardiovascular disease (ASCVD).To detail trends use total out-of-pocket (OOP) expenditures associated with statins representative US adult population from 2002 to 2013.This retrospective longitudinal cohort study was conducted January December 2013. Demographic, medical condition, prescribed medicine information adults 40 years older between 2013 were obtained Medical Expenditure Panel Survey database.Estimated...
Background— Cardiorespiratory fitness (fitness) is associated with cardiovascular disease (CVD) mortality. However, the extent to which improves risk classification when added traditional factors unclear. Methods and Results— Fitness was measured by Balke protocol in 66 371 subjects without prior CVD enrolled Cooper Center Longitudinal Study between 1970 2006; follow-up extended through 2006. Cox proportional hazards models were used estimate of mortality a factor model (age, sex, systolic...
Background: The associations of low-density lipoprotein cholesterol (LDL-C) with cardiovascular disease (CVD) and coronary heart mortality in an exclusively low estimated 10-year risk group are not well delineated. We sought to determine the long-term various LDL-C non–high-density (HDL-C) thresholds CVD a large, cohort. Methods: study sample included participants CCLS (Cooper Center Longitudinal Study) without history or diabetes mellitus defined as (<7.5%) for atherosclerotic events at...
Few data are available to guide clinical recommendations for individuals with high levels of physical activity in the presence clinically significant coronary artery calcification (CAC).